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Browse our S100A8 Proteins (S100A8)

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S100 Calcium Binding Protein A8 Proteins (S100A8)
On are 44 S100 Calcium Binding Protein A8 (S100A8) Proteins from 13 different suppliers available. Additionally we are shipping S100A8 Antibodies (219) and S100A8 Kits (51) and many more products for this protein. A total of 330 S100A8 products are currently listed.
60B8Ag, AI323541, B8Ag, Caga, CFAg, CGLA, CP-10, L1Ag, MA387, MIF, Mrp8, NIF, p8, S100A8
list all proteins Gene Name GeneID UniProt
S100A8 6279 P05109
S100A8 116547 P50115
S100A8 20201 P27005

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S100A8 Proteins (S100A8) by Origin

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Top referenced S100A8 Proteins

  1. Human S100A8 Protein expressed in Wheat germ - ABIN1319072 : Maiseyeu, Badgeley, Kampfrath, Mihai, Deiuliis, Liu, Sun, Parthasarathy, Simon, Croce, Rajagopalan: In vivo targeting of inflammation-associated myeloid-related protein 8/14 via gadolinium immunonanoparticles. in Arteriosclerosis, thrombosis, and vascular biology 2012 (PubMed)
    Show all 5 references for ABIN1319072

  2. Mouse (Murine) S100A8 Protein expressed in Escherichia coli (E. coli) - ABIN667469 : Kerkhoff, Klempt, Sorg: Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). in Biochimica et biophysica acta 1999 (PubMed)
    Show all 2 references for ABIN667469

More Proteins for S100A8 Interaction Partners

Human S100 Calcium Binding Protein A8 (S100A8) interaction partners

  1. Findings suggest that S100A8/A9 may be involved in the inflammatory response with induction of proinflammatory cytokines and may serve as a clinicopathological marker for disease activity in AOSD.

  2. Peripheral blood levels of S100A8 and TRAF6 (show TRAF6 Proteins) in SAE patients were elevated and might be related to the severity of SAE and predict the outcome of SAE.

  3. S100A4 (show S100A4 Proteins), A8, and A9 proteins represent promising marker genes to evaluate the risk potential of suspicious oral lesions in molecular pathology.

  4. Low S100A8/A9 levels may contribute to poor wound healing in colonized chronic wounds with striking difference between diabetic foot ulcers and venous leg ulcers.

  5. Suggest that, in individuals with lichen planus, S100A8 may exert distinct immunomodulatory and cytotoxicity functions.

  6. Serum calprotectin was significantly higher in rheumatoid arthritis patients than controls, and was correlated with disease activity. It was higher in seropositive than in seronegative patients.

  7. S100A8, S100A9 (show S100A9 Proteins) and S100A8/A9 protein levels were higher in chronic rhinosinusitis (CRS (show CARS Proteins)) with nasal polyps (NP) patients, showing increased deposition on extracellular matrix (ECM (show MMRN1 Proteins)) structures in contrast to CRS (show CARS Proteins) without NP and controls.

  8. MRP8/14 is a good marker of disease activity in rheumatoid arthritis, and higher levels predict response to methotrexate.

  9. Blood expression of matrix metalloproteinases 8 and 9 and of their inducers S100A8 and S100A9 (show S100A9 Proteins) supports diagnosis and prognosis of PDAC-associated diabetes mellitus

  10. Increased MRP8/14 levels suggest the instability of the atherosclerotic plaque. ECP reflects the severity of coronary arteries stenosis, predicting atherosclerosis burden. They may become the new biomarkers of CAD.

Pig (Porcine) S100 Calcium Binding Protein A8 (S100A8) interaction partners

  1. Study verified porcine calprotectin (S100A8/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.

Cow (Bovine) S100 Calcium Binding Protein A8 (S100A8) interaction partners

  1. Data suggest that up-regulation of S100A8 and S100A9 (show S100A9 Proteins) is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.

Mouse (Murine) S100 Calcium Binding Protein A8 (S100A8) interaction partners

  1. S100a8 upregulation triggers NF-kappaB (show NFKB1 Proteins) signal pathway through RAGE (show AGER Proteins) and TLR4 (show TLR4 Proteins), in response to laser-induced dermis wound healing.

  2. Although MRP-8/-14 expression is highly increased in experimental, these proteins do not contribute to the pathogenesis in the effector phase of epidermolysis bullosa acquisita and bullous pemphigoid (show DST Proteins).

  3. TLR4 (show TLR4 Proteins), TLR2 also contributed to Mrp8-induced inflammatory response and tolerance.

  4. S100A8 appears to play a crucial role in the activation of the TLR4 (show TLR4 Proteins)/MD-2 (show LY96 Proteins) pathway and the promotion of a tumor growth-enhancing immune microenvironment.

  5. Rps14 (show RPS14 Proteins) haploinsufficiency in del(5q) myelodysplastic syndrome is linked to activation of the innate immune system and induction of S100A8-S100A9 (show S100A9 Proteins) expression, leading to a p53 (show TP53 Proteins)-dependent erythroid differentiation defect.

  6. S100A8 is primarily produced from CXCR2 (show CXCR2 Proteins)-expressing CD11b (show ITGAM Proteins)(+)Gr-1 (show GSR Proteins)(high) cells, and it upregulates TNF-alpha (show TNF Proteins) production in CD11b (show ITGAM Proteins)(+)F4/80(+) cells through cellular cross-talk, which is an important mechanism in the development of Nonalcoholic fatty liver disease

  7. Alarmins S100A8/S100A9 (show S100A9 Proteins) aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.

  8. This study identified Mrp8/14 and TLR4 (show TLR4 Proteins) as important modulators of the leukocyte recruitment cascade during inflammation via integrin beta2.

  9. Inflammation-induced S100A8 promotes colorectal tumorigenesis by acting upstream to activate the Akt1 (show AKT1 Proteins)-Smad5 (show SMAD5 Proteins)-Id3 (show ID3 Proteins) axis.

  10. Data shows that S100A8/A9 plays a critical role during glomerulonephritis, exerting and amplifying autocrine and paracrine proinflammatory effects on bone marrow-derived macrophages, renal endothelial cells, and mesangial cells.

S100A8 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.

Alternative names and synonyms associated with S100A8

  • S100 calcium binding protein A8 (S100A8)
  • S100 calcium binding protein A8 (S100a8)
  • S100 calcium binding protein A8 (calgranulin A) (S100a8)
  • 60B8Ag protein
  • AI323541 protein
  • B8Ag protein
  • Caga protein
  • CFAg protein
  • CGLA protein
  • CP-10 protein
  • L1Ag protein
  • MA387 protein
  • MIF protein
  • Mrp8 protein
  • NIF protein
  • p8 protein
  • S100A8 protein

Protein level used designations for S100A8

S100 calcium binding protein A8 , MRP-8 , S100 calcium-binding protein A8 (calgranulin A) , calgranulin A , calgranulin-A , calprotectin L1L subunit , cystic fibrosis antigen , leukocyte L1 complex light chain , migration inhibitory factor-related protein 8 , protein S100-A8 , urinary stone protein band A , S100 calcium binding protein A8 (calgranulin A) , p8 , calprotectin , BEE11 , P7 , S100 calcium-binding protein A8 , neutrophil cytosolic 7 kDa protein , chemotactic S100 protein , chemotactic cytokine CP-10 , pro-inflammatory S100 cytokine

457319 Pan troglodytes
714740 Macaca mulatta
100294529 Equus caballus
6279 Homo sapiens
116547 Rattus norvegicus
100735514 Cavia porcellus
100127488 Sus scrofa
616818 Bos taurus
490461 Canis lupus familiaris
101104026 Ovis aries
20201 Mus musculus
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