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Our study concludes that the splice site variant identified in the ALX1 gene causes mild form of Frontonasal dysplasia.
we identify critical roles of ALX1 in lung cancer development and progression
Knockdown of the CART1 gene significantly inhibited cell invasion and proliferation and induce cell cycle arrest in S phase.
we found that depletion of ALX1 caused a dramatic cell cycle arrest, followed by massive apoptotic cell death, and eventually resulted in a significant decrease in migration and invasion of the osteosarcoma cell line studied.
hypermethylation of HIST1H4F, PCDHGB6 (show PCDHgB6 Proteins), NPBWR1, ALX1, and HOXA9 (show HOXA9 Proteins) was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer
ALX1 upregulated expression of the key EMT (show ITK Proteins) regulator Snail (SNAI1 (show SNAI1 Proteins)) and that it mediated EMT (show ITK Proteins) activation and cell invasion by ALX1.
Disruption of CART1 (ALX1) causes extreme microphthalmia and severe facial clefting.
Scapula development is governed by genetic interactions of Pbx1 (show PBX1 Proteins) with its family members and with Emx2 (show EMX2 Proteins) via their cooperative control of Alx1
We now demonstrate the function of the aristaless domain in vivo by ectopically expressing normal and mutated forms of Cart1 (show TRAF4 Proteins) and Alx3 (show ALX3 Proteins)
p300/CBP (show CREBBP Proteins) stimulate Cart1 (show TRAF4 Proteins)-dependent transcription activity, and this transactivation is inhibited by E1A (show BCKDHA Proteins) and Tax (show CNTN2 Proteins), oncoproteins that suppress the activity of p300/CBP (show CREBBP Proteins)
The specific function of this gene has yet to be determined in humans\; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly.
ALX homeobox 1
, cartilage paired-class homeoprotein 1
, ALX homeobox protein 1
, ALX homeobox protein 1-like
, cartilage homeo protein 1
, cartilage homeoprotein 1