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Browse our Ectodysplasin A Proteins (EDA)

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Ectodysplasin A Proteins (EDA)
On are 14 Ectodysplasin A (EDA) Proteins from 6 different suppliers available. Additionally we are shipping Ectodysplasin A Antibodies (105) and Ectodysplasin A Kits (10) and many more products for this protein. A total of 136 Ectodysplasin A products are currently listed.
0610040D20Rik, 2900052N06Rik, c11orf5, ECTD1, ED1, ED1-A1, ED1-A2, Eda-A1, Eda-A2, EDA1, EDA2, HED, HED1, mED1, ODT1, RGD1563178, si:ch73-223d24.5, STHAGX1, Ta, tabby, XHED, XLHED
list all proteins Gene Name GeneID UniProt
EDA 66070 Q9JHS9
EDA 1896 Q92838
Rat EDA EDA 302424  

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Ectodysplasin A Proteins (EDA) by Origin

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More Proteins for Ectodysplasin A Interaction Partners

Mouse (Murine) Ectodysplasin A (EDA) interaction partners

  1. Wnt (show WNT2 Proteins), Eda, and Shh (show SHH Proteins) have roles in touch dome Merkel cell development

  2. Using an ex vivo culture system, we show that suppression of canonical Wnt (show WNT2 Proteins) signalling leads to a dose-dependent inhibition of supernumerary placodes in K14 (show KRT14 Proteins)-Eda tissue explants.

  3. Eda and activin A (show INHBA Proteins) are upstream regulators of Foxi3 (show FOXI3 Proteins) in skin appendage placodes

  4. Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 (show FGF20 Proteins) signaling.

  5. NF-kappaB (show NFKB1 Proteins) downstream of the TNF (show TNF Proteins)-like ligand ectodysplasin (Eda) is identified as a unique regulator of embryonic and prepubertal ductal morphogenesis.

  6. Data found that Eda regulates growth and branching of the SMG (show SNRPG Proteins) via transcription factor NF-kappaB (show NFKB1 Proteins) in the epithelium, and that the hedgehog (show SHH Proteins) pathway is an important mediator of Eda/NF-kappaB (show NFKB1 Proteins).

  7. Dkk4 (show DKK4 Proteins) affects an auxiliary pathway for Eda-independent development of secondary hair

  8. Treatment of Eda-/- minor salivary gland explants with EDA A1 rescues minor salivary gland induction.

  9. The ectodysplasin-A gene plays a role in normal bone development in mice.

  10. Eda and Edar (show EDAR Proteins) expression is confined to the ectoderm and occurs in a pattern that suggests a role of ectodysplasin/Edar (show EDAR Proteins) signaling in the interactions between the ectodermal compartments and the formation and function of hair placodes.

Human Ectodysplasin A (EDA) interaction partners

  1. EDA is an important candidate gene for two developmental diseases sharing the common feature of the congenital lack of teeth. In addition, these results can support the hypothesis that X-linked HED and EDA-related NTA are the same disease with different degrees of severity.

  2. EDA-A2 and its receptor XEDAR (show EDA2R Proteins) are overexpressed in epithelial cells of salivary glands in Sjogren's syndrome patients, in comparison with healthy individuals. The EDA-A2/XEDAR (show EDA2R Proteins) system in these cells is involved in the induction of apoptosis via CASP3 (show CASP3 Proteins) activation.

  3. Based on a computerized protein structure analysis, we suggest that the change p.Arg289His in EDA impairs protein stabilization and thus might possibly be involved in the development of oligodontia concomitant with a mild ED phenotype.

  4. we identified a novel and three reported EDA missense mutations in four of six patients with X-linked hypohidrotic ectodermal dysplasia. Missense mutations and the mutations affecting the tumor necrosis factor (show TNF Proteins) homology domain were correlated with fewer missing teeth.

  5. Our findings indicate that a novel mutation (c.878T>G) of EDA is associated with XLHED and adds to the repertoire of EDA mutations.

  6. We found a novel missense mutation in exon 1 of the EDA1 gene in a putative Mayan family from Mexico with XL-HED.

  7. A novel missense mutation in the EDA gene in a Chinese family with X-linked hypohidrotic ectodermal dysplasia.

  8. dentified a novel deletion mutation located in exon 1 which if expressed would produce a highly truncated protein in a Chinese Han family with X-linked hypohidrotic ectodermal dysplasia

  9. novel non-synonymous mutation in ectodysplasin A (EDA) associated with non-syndromic X-linked dominant congenital tooth agenesis

  10. novel one-nucleotide deletion mutation (c.855delG) of EDA in exon 8 which caused premature termination of the polypeptide at amino acid 307 was confirmed

Cow (Bovine) Ectodysplasin A (EDA) interaction partners

  1. Authors identifya mutation, never described before, that changes the regulation of alternative splicing in the EDA gene and causes ectodermal dysplasia in cattle.

  2. The 161-bp-long LINE1-derived-pseudoexon introduces a shift in reading frame and a premature stop codon early in EDA exon 2 and is probably the cause of XHED in this Danish Red Holstein family.

  3. describe a novel mutation of the EDA gene in which a 19 bp deletion in exon 1 in male Holstein calves demonstrated the phenotypic features of EDA

Zebrafish Ectodysplasin A (EDA) interaction partners

  1. Eda and edar (show EDAR Proteins) are not required for early development but are specific for the development of adult skeletal and dental structures.

Ectodysplasin A (EDA) Protein Profile

Protein Summary

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.

Alternative names and synonyms associated with Ectodysplasin A (EDA)

  • ectodysplasin A (EDA)
  • CWC15 homolog (S. cerevisiae) (Cwc15)
  • ectodysplasin A (eda)
  • ectodysplasin-A (Eda)
  • 0610040D20Rik protein
  • 2900052N06Rik protein
  • c11orf5 protein
  • ECTD1 protein
  • ED1 protein
  • ED1-A1 protein
  • ED1-A2 protein
  • Eda-A1 protein
  • Eda-A2 protein
  • EDA1 protein
  • EDA2 protein
  • HED protein
  • HED1 protein
  • mED1 protein
  • ODT1 protein
  • RGD1563178 protein
  • si:ch73-223d24.5 protein
  • STHAGX1 protein
  • Ta protein
  • tabby protein
  • XHED protein
  • XLHED protein

Protein level used designations for Ectodysplasin A Proteins (EDA)

ectodysplasin A , embryonic development factor 1 , nucleoporin , protein CWC15 homolog , spliceosome-associated protein CWC15 homolog , X-linked anhidroitic ectodermal dysplasia protein , ectodysplasin-A , oligodontia 1 , ectodysplasin A1 , ectodermal dysplasia 1, anhidrotic , ectodermal dysplasia protein , ectodysplasin-1 , nackt , nkt , EDA protein homolog

473652 Pan troglodytes
66070 Mus musculus
1896 Homo sapiens
769069 Gallus gallus
491935 Canis lupus familiaris
616179 Bos taurus
798740 Danio rerio
13607 Mus musculus
302424 Rattus norvegicus
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