Browse our HAND1 Proteins (HAND1)

Full name:
Heart and Neural Crest Derivatives Expressed 1 Proteins (HAND1)
On are 13 Heart and Neural Crest Derivatives Expressed 1 (HAND1) Proteins from 5 different suppliers available. Additionally we are shipping HAND1 Antibodies (86) and HAND1 Kits (6) and many more products for this protein. A total of 110 HAND1 products are currently listed.
bHLHa27, eHAND, Ehand1, hand-1, Hand1, hand1-A, HXT, Th1, Thing1
list all proteins Gene Name GeneID UniProt
HAND1 9421 O96004
HAND1 59112 P97832
HAND1 15110 Q64279

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HAND1 Proteins (HAND1) by Origin

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Top referenced HAND1 Proteins

  1. Human HAND1 Protein expressed in Escherichia coli (E. coli) - ABIN1098692 : Scott, Anson-Cartwright, Riley, Reda, Cross: The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. in Molecular and cellular biology 2000 (PubMed)
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More Proteins for HAND1 Interaction Partners

Human Heart and Neural Crest Derivatives Expressed 1 (HAND1) interaction partners

  1. Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog (show NANOG Proteins), Oct3/4 (show POU5F1 Proteins), Otx2 (show OTX2 Proteins), Flk1 (show KDR Proteins)) suggesting that Hand1 expression may be essential to attenuate the EMT (show ITK Proteins) and our findings underscore a novel role for Hand1 in medulloblastoma metastasis.

  2. association of HAND1 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot

  3. These findings expand the phenotypic spectrum linked to HAND1 mutations, suggesting potential implications for the development of novelo prophylactic and therapeutic strategies for DORV.

  4. HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy.

  5. Combined expression of NKX2-5 (show NKX2-5 Proteins), HAND1, and NOTCH1 (show NOTCH1 Proteins) coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome.

  6. These data show that miR (show MLXIP Proteins)-363 negatively regulates the expression of HAND1

  7. Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors.

  8. DNA methylation (show HELLS Proteins) status of NKX2-5 (show NKX2-5 Proteins), GATA4 (show GATA4 Proteins) and HAND1 in patients with tetralogy of fallot

  9. Increased methylation levels of HAND1 is associated with highly active Helicobacter pylori-related gastritis.

  10. This is the first report of mutations in the HAND1 gene in Chinese patients with VSD and provides new insight into the etiology of VSD

Xenopus laevis Heart and Neural Crest Derivatives Expressed 1 (HAND1) interaction partners

  1. a single nucleotide substitution in the hand1.S promoter was responsible for the reduced expression in the heart.

  2. increased vascular endothelial growth factor(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis

Mouse (Murine) Heart and Neural Crest Derivatives Expressed 1 (HAND1) interaction partners

  1. Surviving Hand1;Hand2 (show HAND2 Proteins) mutants display diminished cardiac function that is rescued by concurrent ablation of Hand-null cardiomyocytes. Collectively, we conclude that, within a mixed cardiomyocyte population, removal of defective myocardium and replacement with healthy endogenous cardiomyocytes may provide an effective strategy for cardiac repair.

  2. Within the pharyngeal arches, the distal-most of the proximo-distally oriented subdomains of cranial neural crest cells, the distal cap, is marked by expression of the transcription factor Hand1 and gives rise to the ectomesenchymal derivatives of the lower incisors.

  3. Data suggest the protection role of haploinsufficiency of heart and neural crest derivatives expressed transcript 1 protein (Hand1) after acute myocardial infarction (AMI (show CFD Proteins)).

  4. Hand1 is involved in proper osteogenesis of the bone collar via its control of Ihh (show IHH Proteins). Hand1 overexpression in the osteochondral progenitors caused defective prenatal diaphysis ossification. Hand1 inhibited Runx2 (show RUNX2 Proteins) transactivation of the Ihh (show IHH Proteins) proximal promoter.

  5. Re-expression of HAND1 in colon cancer cells induces terminal differentiation.

  6. Hand1 phosphoregulation in the distal arch neural crest has a critical role in craniofacial morphogenesis

  7. Suggest that prenatal alcohol exposure causes the over-expression of DHAND (show HAND2 Proteins) and EHAND by increasing H3K14ac in the fetal heart.

  8. Hand1 is part of a novel regulatory pathway linking cardiac oxygen levels with oxygen consumption.

  9. that Hand1 homodimer plays a dominant role during development and its expression dosage is critical for survival, whereas Hand1 heterodimers can be either dispensable or play a regulatory role to modulate the activity of Hand1 homodimer in vivo.

  10. Data suggest that stress-induced MAPK8 (show MAPK8 Proteins)/9 and PRKAA1 (show PRKAA1 Proteins)/2 regulate transcription factors Eomes (show EOMES Proteins)/HAND1 and ID2, respectively. Together this network mediates induction of CSH1 (show PRL3D1 Proteins) by stress.

HAND1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.

Alternative names and synonyms associated with HAND1

  • heart and neural crest derivatives expressed 1 (HAND1)
  • heart and neural crest derivatives expressed 1 (hand1)
  • eHAND basic helix-loop-helix transcription factor (EHAND)
  • heart and neural crest derivatives expressed 1 (Hand1)
  • heart and neural crest derivatives expressed transcript 1 (Hand1)
  • bHLHa27 protein
  • eHAND protein
  • Ehand1 protein
  • hand-1 protein
  • Hand1 protein
  • hand1-A protein
  • HXT protein
  • Th1 protein
  • Thing1 protein

Protein level used designations for HAND1

heart- and neural crest derivatives-expressed protein 1 , heart and neural crest derivatives expressed 1 , basic helix-loop-helix transcription factor HAND1 , eHAND basic helix-loop-helix transcription factor , Heart- and neural crest derivatives-expressed protein 1 , class A basic helix-loop-helix protein 27 , extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 , heart and neural crest derivatives expressed transcript 1 , heart and neural crest derivatives-expressed protein 1 , eHAND , helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast , thing-1

489164 Canis lupus familiaris
541594 Sus scrofa
462209 Pan troglodytes
549497 Xenopus (Silurana) tropicalis
714450 Macaca mulatta
100009575 Oryctolagus cuniculus
9421 Homo sapiens
59112 Rattus norvegicus
517952 Bos taurus
395812 Gallus gallus
443353 Ovis aries
373663 Xenopus laevis
15110 Mus musculus
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