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Simulation of HEY1 Ser (show SIGLEC1 Proteins)-68 phosphorylation prevents its interaction with p53 (show TP53 Proteins), RPL11 (show RPL11 Proteins) and MDM2 (show MDM2 Proteins) and abolishes HEY1 migration to nucleolar caps (show CAPS Proteins) upon ribosomal stress. Our findings uncover a novel mechanism for cross-talk between Notch (show NOTCH1 Proteins) signalling and nucleolar stress
Pancreatic involvement occurs in mesenchymal chondrosarcoma harboring the HEY1-NCOA2 (show NCOA2 Proteins) gene fusion.
HGF (show HGF Proteins)-induced FRA1 (show FOSL1 Proteins) activation is associated with the fibrosis-dependent development of Hepatocellular Carcinoma.
Expression of Hey1 induces translocation of FBXO45 (show FBXO45 Proteins) into the nucleus.
Overexpression of HEY1 and HEY2 (show HEY2 Proteins) in esophageal squamous cell carcinoma (ESCC) is correlated to different indices of poor prognosis, and it is extrapolated that such overexpression is important in progression and development of ESCC tumorigenesis.
bone morphogenic proteins within the serum of cell culture medium are potent inducers of endothelial Hey1 and Hey2 (show HEY2 Proteins) gene expression within the first few hours after medium change
PML (show PML Proteins) degradation mechanism through Notch (show NOTCH1 Proteins)/Hey1-induced repression of the PML (show PML Proteins) deubiquitinase USP11 (show USP11 Proteins) involved in brain tumour pathogenesis
MMP9 (show MMP9 Proteins) was a downstream effector of HEY1 that promotes the invasion of osteosarcoma cells. Knockdown of HEY1 decreased the expression of MMP9 (show MMP9 Proteins).
In prostate tumors, the overexpression of PTOV1 was associated with decreased expression of HEY1 and HES1, and this correlation was significant in metastatic lesions.
a new HRD1 (show SYVN1 Proteins)-associated membrane protein named HERP2, which is homologous to the previously identified HRD1 (show SYVN1 Proteins) partner HERP1 (show HEY2 Proteins). Despite sequence homology, HERP2 is constitutively expressed in cells, whereas HERP1 (show HEY2 Proteins) is highly induced by ER stress.
A Jagged1 (show JAG1 Proteins)-Hey1 signal might mediate the impairment of angiogenesis induced by Ang II (show AGT Proteins) during cardiac hypertrophy.
Cyclic stretch enhanced the BMP-2induced osteoblastic differentiation through the inhibition of Hey1.
Hes (show ATCAY Proteins)/Hey signaling at the Atoh1 (show ATOH1 Proteins) promoter has a role in selection of cell fate in the organ of Corti
These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII (show NR2F2 Proteins) via downregulating the Notch (show NOTCH1 Proteins) signaling target gene Hey1.
Hey proteins mechanistically repress target genes via histone deacetylase (show HDAC1 Proteins) recruitment and histone deacetylation.
Hey1 and Hey2 (show HEY2 Proteins) in endothelial cells play important roles in vascular development.
findings indicate that Hey1 and Hey2 (show HEY2 Proteins) control the spatial and temporal pattern of auditory HC differentiation.
This study demonistrated that demonstrates that the lack of Hesr1 leads to an alteration in sensitivity to dopamine accompanied by enhanced prepulse inhibition.
A muscle-specific (show EIF3K Proteins) regulatory element of p57(kip2 (show CDKN1C Proteins)) directly activated by muscle regulatory factors in myoblasts but repressed by the Notch (show NOTCH1 Proteins) targets Hes1/Hey1 in progenitor cells, is identified.
Notch (show NOTCH1 Proteins)-RBPjk (show RBPJ Proteins) signaling functions in part through Hey1-mediated inhibition of NFATc1 (show NFATC1 Proteins) to suppress osteoblastogenesis, contributing to bone homeostasis in vivo
Expression of seven hairy/E(spl (show SGPL1 Proteins)) (her) genes is reported in three neurogenic areas of the adult zebrafish brain (telencephalon, hypothalamus, and midbrain) in relation to radial glia, proliferation, and neurogenesis.
hey1 represents a target of Delta-Notch (show NOTCH1 Proteins) signaling dynamically expressed during somite formation in zebrafish
Results suggest that the negative regulatory loops between BMP/Tbx2 (show TBX2 Proteins) and Gremlin (show GREM1 Proteins) or Hey1 are responsible for defining the territory of the pronephric nephron.
HRT1 encodes a bhlh domain motif, a transcription repressor, which acts as an extended dimerization domain that contributes to the selection of partners.
XHRT1 plays an important role in glomerular development and early proximodistal patterning. [Xenopus HRT1]
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.
HES-related repressor protein 1
, HES-related repressor protein 2
, basic helix-loop-helix protein OAF1
, cardiovascular helix-loop-helix factor 2
, class B basic helix-loop-helix protein 31
, hairy and enhancer of split-related protein 1
, hairy-related transcription factor 1
, hairy/enhancer-of-split related with YRPW motif protein 1
, bHLH protein Hesr-1/Hey1
, cardiovascular basic helix-loop-helix factor 2
, Hairy/E(spl)-related with YRPW motif 1
, basic helix-loop-helix transcription factor
, protein xbc8