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loss of the orthologue kdm2aa in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanomas at a high frequency
we identified KDM2B, a reader for methylated CpGs, as the target of miR (show MLXIP Proteins)-448 that represses glycolysis and promotes oxidative phosphorylation in gastric cancer
High KDM2B expression is associated with Neuroblastomas.
novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations
A missense mutation in the KDM2B gene is associated with malignant peripheral nerve sheath tumors.
we propose histone demethylase KDM2B and histone methyltransferase SETD1B as the two most plausible candidate genes involved in intellectual disability, autism, epilepsy, and craniofacial anomalies
NDY1/KDM2B functions as a master regulator of polycomb (show CBX2 Proteins) complexes and controls self-renewal of breast cancer stem cells.
KDM2B is an important mediator of hematopoietic cell development and has opposing roles in tumor progression that are dependent on cellular context.
Jhdm1b is a positive regulator of glycolysis, glutaminolysis, and pyrimidine synthesis in HeLa cells.
The protein lysine demethylases Kdm2a (show KDM2A Proteins) and Kdm2b regulate the turnover of non-phosphorylated beta-catenin (show CTNNB1 Proteins) specifically within the nucleus via direct interaction with the fourth and fifth armadillo (show PKP1 Proteins) repeats.
the KDM2B/let-7b/EZH2 (show EZH2 Proteins) axis is involved in epigenetic regulation in MDS (show PAFAH1B1 Proteins), with direct effects on di- and tri (show VANGL2 Proteins)-methylation of H3K27.
Fbxl10 plays a critical role in migration by binding to the promoter region of migration-associated genes and thereby might influences cell behaviour to a possibly more aggressive phenotype.
this study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292
Fbxl10 is a bona fide oncogene, whose deregulated expression contributes to the development of leukemia involving metabolic proliferative advantage and Nsg2-mediated impaired differentiation.
FBXL10 protects Polycomb (show CBX2 Proteins)-occupied promoters against ectopic de novo methylation.
Genetic ablation in embryonic stem cells reveal that deletion of PRC1 (show PRC1 Proteins) has genome-wide effects on PRC2 occupancy and H3K27me3; recognition of nonmethylated DNA by KDM2B, part of the PCGF1 (show PCGF1 Proteins)/PRC1 (show PRC1 Proteins) variant complex, is important for deposition of H2AK119ub1 and recruitment of PRC2 to a subset of CpG island targets and that this activity is essential for normal mouse development.
Fbxl10 has a key role in regulating Ring1B (show RNF2 Proteins) recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells.
KDM2B silencing abrogated tumorigenicity of PDAC cell lines exhibiting loss of epithelial differentiation, whereas KDM2B overexpression cooperated with KrasG12D to promote PDAC formation in mouse models.
a regulatory role of Fbxl10 in cell morphology, chemokine (show CCL1 Proteins) expression, and the metabolic control of fibroblasts.
The KDM2B-let-7-EZH2 pathway contributes to the proliferation of immortal Ink4a/Arf null fibroblasts suggesting the histone-modifying enzyme functions more broadly in the regulation of cellular proliferation.
Kdm2b/Jhdm1b functions as an oncogene (show RAB1A Proteins) and plays a critical role in leukemia development and maintenance.
genetic makeup of three inbred cattle strongly supports the causality of the KDM2B mutation
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
JmjC domain-containing histone demethylation protein 1B
, lysine (K)-specific demethylase 2B
, CXXC-type zinc finger protein 2
, F-box and leucine-rich repeat protein 10
, F-box protein FBL10
, F-box/LRR-repeat protein 10
, JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein
, [Histone-H3]-lysine-36 demethylase 1B
, jmjC domain-containing histone demethylation protein 1B
, jumonji C domain-containing histone demethylase 1B
, jumonji domain-containing EMSY-interactor methyltransferase motif protein
, lysine-specific demethylase 2B
, protein-containing CXXC domain 2
, F-box protein containing leucine repeats 10