Browse our KDM6A Proteins (KDM6A)

On are 5 Lysine (K)-Specific Demethylase 6A (KDM6A) Proteins from 4 different suppliers available. Additionally we are shipping KDM6A Antibodies (30) and many more products for this protein. A total of 41 KDM6A products are currently listed.
bA386N14.2, KABUK2, RGD1565481, Utx, Uty
list all proteins Gene Name GeneID UniProt
KDM6A 7403 O15550
KDM6A 22289 O70546
Rat KDM6A KDM6A 100310845  

KDM6A Proteins (KDM6A) by Origin

More Proteins for KDM6A Interaction Partners

Human Lysine (K)-Specific Demethylase 6A (KDM6A) interaction partners

  1. Mutation in KDM6A gene is associated with cancer more frequently in males.

  2. Pathogenic variants in KMT2D resulting in protein truncation in 43% (6/14; of which 3 are novel) of all cases were detected, while analysis of KDM6A was negative. MLPA analysis was negative in all instances.

  3. Kdm6a and Kdm6b were found to be significantly overexpressed in Malignant pleural mesothelioma (MPM) at the mRNA level. However, tests examining if targeting therapeutically Kdm6a/b using a specific small molecule inhibitor was potentially useful for treating MPM, revealed that members of the Kdm6 family may not be suitable candidates for therapy

  4. The results define UTX as a bivalency-resolving histone modifier necessary for stem cell differentiation

  5. UTX gene expression in renal cell carcinoma (show MOK Proteins) and bladder cancer.

  6. Mutations of the epigenetic genes KMT2D and KDM6A cause dysregulation of certain developmental genes and account for the multiple congenital anomalies of the syndrome

  7. UTX positively regulates E-cadherin (show CDH1 Proteins) expression in colon cancer cells.

  8. UTX is a prominent tumour suppressor that functions as a negative regulator of EMT (show ITK Proteins)-induced Cancer Stem Cell-like properties by epigenetically repressing epithelial-mesenchymal transition -TFs.

  9. Kabuki syndrome may be caused by mutations in one of two histone methyltransferase genes: KMT2D and KDM6A.

  10. Our results provide further support for the similar roles of KMT2D and KDM6A in the etiology of KS by using a vertebrate model organism to provide direct evidence of their roles in the development of organs and tissues affected in KS patients.

Mouse (Murine) Lysine (K)-Specific Demethylase 6A (KDM6A) interaction partners

  1. These results suggest that the demethylase (show MBD2 Proteins) activity of Jmjd3, but not that of Utx, affects mouse axial patterning in concert with alterations in Hox (show MSH2 Proteins) gene expression.

  2. Utx governs adipogenesis by regulating c-Myc (show MYC Proteins) in a differentiation stage-specific manner

  3. Ectopic expression of KDM6A antagonized TGF-beta (show TGFB1 Proteins)-induced epithelial-mesenchymal transition and cell migration of lung cancer cells through its demethylase (show MBD2 Proteins) activity.

  4. this study reveals how UTX regulates the development of invariant natural killer T cells through multiple epigenetic mechanisms

  5. The results define UTX as a bivalency-resolving histone modifier necessary for stem cell differentiation

  6. Study demonstrated that the mammary luminal lineage relies on KDM6A to ensure a transcription program leading to differentiated alveoli. Failure to fully implement this program results in structurally and functionally impaired mammary tissue.

  7. differentiating embryonic stem cells (ESCs (show NR2E3 Proteins)) depend on KDM6 and the H3K27me3 demethylase (show MBD2 Proteins) activity is crucially involved in DNA damage response and survival of differentiating ESCs (show NR2E3 Proteins).

  8. a critical role for the enzymatic activity of UTX in activating muscle-specific (show EIF3K Proteins) gene expression during myofiber regeneration and have revealed a physiological role for active H3K27 demethylation in vivo.

  9. Results propose that Utx plays important roles in osteoblast differentiation by controlling the expressions of Runx2 (show RUNX2 Proteins) and Osterix (show SP7 Proteins).

  10. Utx is required for T-cell development.

KDM6A Protein Profile

Protein Summary

This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3.

Alternative names and synonyms associated with KDM6A

  • lysine (K)-specific demethylase 6A (KDM6A)
  • lysine (K)-specific demethylase 6A (Kdm6a)
  • bA386N14.2 protein
  • KABUK2 protein
  • RGD1565481 protein
  • Utx protein
  • Uty protein

Protein level used designations for KDM6A

lysine (K)-specific demethylase 6A , bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)) , histone demethylase UTX , lysine-specific demethylase 6A , ubiquitously transcribed tetratricopeptide repeat protein X-linked , ubiquitously-transcribed TPR gene on the X chromosome , ubiquitously-transcribed TPR protein on the X chromosome , ubiquitously transcribed tetratricopeptide repeat, X chromosome , 4lysine (K)-specific demethylase 6A , ubiquitously transcribed TPR protein on the X chromosome , ubiquitously transcribed X chromosome tetratricopeptide repeat protein , ubiquitously transcribed tetratricopeptide repeat gene, X chromosome , ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome

100081798 Ornithorhynchus anatinus
100539898 Meleagris gallopavo
100592229 Nomascus leucogenys
7403 Homo sapiens
491845 Canis lupus familiaris
22289 Mus musculus
100310845 Rattus norvegicus
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