Browse our RIPPLY2 Proteins (RIPPLY2)

Full name:
Ripply2 Homolog (Zebrafish) Proteins (RIPPLY2)
On www.antibodies-online.com are 4 Ripply2 Homolog (Zebrafish) (RIPPLY2) Proteins from 3 different suppliers available. Additionally we are shipping RIPPLY2 Antibodies (5) and many more products for this protein. A total of 10 RIPPLY2 products are currently listed.
Synonyms:
2610206G21Rik, AL022943, C030002E08Rik, C6orf159, dJ237I15.1, Gm1122, Gm1127, lin-41, Lin41, mlin-41, mLin41, Ripply2
list all proteins Gene Name GeneID UniProt
RIPPLY2 134701 Q5TAB7
RIPPLY2 382089 Q2WG76

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RIPPLY2 Proteins (RIPPLY2) by Origin

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Human Ripply2 Homolog (Zebrafish) (RIPPLY2) interaction partners

  1. Functional analysis of the mouse Ripply2 ortholog.

Mouse (Murine) Ripply2 Homolog (Zebrafish) (RIPPLY2) interaction partners

  1. suggest that Trim71 (show TRIM71 Proteins) keeps priming steps of differentiation in check, which do not pre-require a loss of the pluripotency network in ES cells

  2. Compound heterozygous mutations in RIPPLY2 are associated with segmentation defects of the vertebrae, a new gene for this condition.

  3. Ripply2 represses Tbx6 (show TBX6 Proteins) in a Mesp2 (show Mesp2 Proteins)-independent manner, which contributes to the accurate segmental border formation.

  4. Ripply2-Mesp2 negative-feedback loop is essential for the periodic generation of the rostro-caudal polarity within a somite.

  5. Two well-known E3 ubiquitin ligases, Trim25 (show TRIM25 Proteins) (also called Efp (show TRIM25 Proteins)) and Trim71 (show TRIM71 Proteins) (also called Lin41 (show TRIM71 Proteins)), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.

  6. conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal properties, respectively

  7. mLin41 acts as a temporal regulator to promote neural progenitor cell maintenance, not via the regulation of AGO2 (show EIF2C2 Proteins) stability, but through FGF signaling.

  8. Rostro-caudal pattern is established by dynamic interaction of Notch (show NOTCH1 Proteins) activity with two Mesp2 (show Mesp2 Proteins) domains, which are defined in successive segmentation cycles by Notch (show NOTCH1 Proteins), Tbx6 (show TBX6 Proteins) and Ripply1 (show RIPPLY1 Proteins)/2.

  9. Defects in segmentation of the axial skeleton were observed in the ripply2 homozygous mutant mice.

  10. findings show that Ripply2 is expressed in the anterior presomitic mesoderm and that it lies downstream of Wnt3a; data are consistent with Ripply2 functioning as a segment boundary determination gene during mammalian embryogenesis

RIPPLY2 Protein Profile

Protein Summary

May be involved in controlling the timing of organ formation during development (By similarity).

Alternative names and synonyms associated with RIPPLY2

  • ripply transcriptional repressor 2 (RIPPLY2)
  • ripply2 (ripply2)
  • ripply2 homolog (zebrafish) (Ripply2)
  • tripartite motif-containing 71 (Trim71)
  • 2610206G21Rik protein
  • AL022943 protein
  • C030002E08Rik protein
  • C6orf159 protein
  • dJ237I15.1 protein
  • Gm1122 protein
  • Gm1127 protein
  • lin-41 protein
  • Lin41 protein
  • mlin-41 protein
  • mLin41 protein
  • Ripply2 protein

Protein level used designations for RIPPLY2

protein ripply2 , ripply2 homolog , E3 ubiquitin-protein ligase TRIM71 , lin-41 homolog , protein lin-41 homolog , tripartite motif-containing protein 71

GENE ID SPECIES
134701 Homo sapiens
654447 Danio rerio
382089 Mus musculus
636931 Mus musculus
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