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Browse our anti-STIL (STIL) Antibodies

Full name:
anti-SCL/TAL1 Interrupting Locus Antibodies (STIL)
On www.antibodies-online.com are 19 SCL/TAL1 Interrupting Locus (STIL) Antibodies from 4 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 21 STIL products are currently listed.
Synonyms:
chunp6907, MCPH7, SIL, sill, zgc:110502
list all antibodies Gene Name GeneID UniProt
STIL 313506  
STIL 6491 Q15468
STIL 20460 Q60988

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Most Popular Reactivities for anti-STIL (STIL) Antibodies

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Human SCL/TAL1 Interrupting Locus (STIL) interaction partners

  1. Reconstituting mouse embryonic fibroblasts lacking endogenous Stil, the authors show that STIL oligomerization mediated by these residues is not only important for the centrosomal functions of STIL during the canonical duplication process but also for de-novo formation of centrosomes.

  2. Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 (show TLX3 Antibodies) and SIL (show PMEL Antibodies)/TAL (show TALDO1 Antibodies) but a higher incidence of NKX2-5 (show NKX2-5 Antibodies) expression than recorded in Western countries

  3. data provide evidence for novel functions of the human oncogene (show RAB1A Antibodies) Stil in neural toxic susceptibility.

  4. The authors suggest that the STIL-coiled-coil region/PLK4 (show PLK4 Antibodies) interaction mediates PLK4 (show PLK4 Antibodies) activation as well as stabilization of centriolar PLK4 (show PLK4 Antibodies) and plays a key role in centriole duplication.

  5. The STIL p.Gly717Glu mutation was not able to fully restore the centriole duplication failure following depletion of endogenous STIL protein indicating the deleterious role of the mutation.

  6. Negative feedback by centriolar STIL regulates bimodal centriolar distribution of Plk4 (show PLK4 Antibodies) and seemingly restricts occurrence of procentriole formation to one site on each parental centriole.

  7. studies provide the first structural insight into how the malfunction of centriole proteins results in human disease and also reveal that the CPAP (show CENPJ Antibodies)-STIL interaction constitutes a conserved key step in centriole biogenesis

  8. STIL mutation causes autosomal recessive microcephalic lobar holoprosencephaly.

  9. propose that centriole amplification triggered by STIL stabilization is the underlying cause of microcephaly in human patients with corresponding STIL mutations

  10. results provide direct evidence for the involvement of Stil in dopaminergic cell proliferation

Mouse (Murine) SCL/TAL1 Interrupting Locus (STIL) interaction partners

  1. STIL(-/-) mouse embryos do not contain centrioles or primary cilia, suggesting that these organelles are not essential for mammalian development until mid gestation.

  2. Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.

  3. cloned a mouse homolog of the human SIL promoter

Xenopus laevis SCL/TAL1 Interrupting Locus (STIL) interaction partners

  1. Scl (show TAL1 Antibodies) is required for the programming of adult haemangioblasts.

Zebrafish SCL/TAL1 Interrupting Locus (STIL) interaction partners

  1. decreased expression of Stil resulted in increased toxic susceptibility of retinal dopaminergic cells to 6-hydroxydopamine

  2. Scl (show TAL1 Antibodies)/Lmo2 (show LMO2 Antibodies) complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other

  3. These data, taken together, identify SIL as a novel, vertebrate-specific regulator of mitotic spindle assembly.

STIL Antigen Profile

Antigen Summary

This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with STIL

  • Scl/Tal1 interrupting locus (Stil) antibody
  • SCL/TAL1 interrupting locus (STIL) antibody
  • SCL/TAL1 interrupting locus (stil) antibody
  • TAL1 (SCL) interrupting locus (stil) antibody
  • chunp6907 antibody
  • MCPH7 antibody
  • SIL antibody
  • sill antibody
  • zgc:110502 antibody

Protein level used designations for STIL

Tal1 interrupting locus , SCL-interrupting locus protein , TAL-1-interrupting locus protein , SCL-interrupting locus protein homolog , TAL1 (SCL) interrupting locus like , cassiopeia , csp , nbb

GENE ID SPECIES
313506 Rattus norvegicus
510012 Bos taurus
6491 Homo sapiens
20460 Mus musculus
431864 Xenopus laevis
192317 Danio rerio
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