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WT1 expression status represents a good molecular marker of prognosis, response to treatment, and minimal residual disease monitoring in acute myeloid leukemia (show BCL11A ELISA Kits) with normal karyotype
Review/Meta-analysis: WT1 rs16754 polymorphism is associated with better survival in acute myeloid leukemia (show BCL11A ELISA Kits).
we report that CUG initiation site for WT1 protein synthesis (CUG)-translated WT1 (cugWT1), an N-terminally extended form of canonical AUG initiation site for WT1 protein synthesis (AUG)-translated WT1 (augWT1), was overexpressed in most cancer cell lines and cancer tissues and functioned as an oncogene (show RAB1A ELISA Kits)
Furthermore, chromatin immunoprecipitation assays revealed that COL4A1 (show COL4A1 ELISA Kits) and WNT4 (show WNT4 ELISA Kits) promoter is directly bound by wild-type WT1 protein, but not the p.F435L WT1 variant. Thus, we identified a novel functional variant of WT1 functionally associated with idiopathic non-obstructive azoospermia.
Data reveal that MiR (show MLXIP ELISA Kits)-193a directly targets WT1 and indirectly modulates E-cadherin (show CDH1 ELISA Kits) and that overexpression of WT1 partially prevents miR (show MLXIP ELISA Kits)-193a-induced inhibition of migration and invasion of non-small cell lung cancers, suggesting that WT1 plays an important role in the anti-metastasis by miR (show MLXIP ELISA Kits)-193a.
WT1 cooperates with TET2 (show TET2 ELISA Kits) to upregulate MEG3 (show FAM129B ELISA Kits) expression places TET2 (show TET2 ELISA Kits)-WT1-MEG3 (show FAM129B ELISA Kits) signaling axis as a central tumor suppressive pathway in AML (show RUNX1 ELISA Kits), therefore emphasizing the potentials of this axis in AML (show RUNX1 ELISA Kits) diagnosis and therapy.
Concomitant monitoring of WT1 and FLT3 (show FLT3 ELISA Kits)-ITD expression in FLT3 (show FLT3 ELISA Kits)-ITD acute myeloid leukemia (show BCL11A ELISA Kits) patients
Study shows WT1 Haploinsufficiency Supports Milder Renal Manifestation in Two Patients with Denys-Drash Syndrome.
WT1 isoform-overexpressing cell sublines were established from a triple negative breast cancer cell line, MDA-MB-231, by stable transfection, and the aggressive behavior of the cell sublines were evaluated. Only the WT1 isoform B- and isoform C-overexpressing cell sublines showed the significant increase in vasculogenic mimicry forming capability compared to the parental cell line and other isoform cell sublines.
This study demonstrated that WT1 is a good marker for monitoring the response to therapy in patients affected by myelofibrosis.
WT1 interference with Wnt (show WNT2 ELISA Kits) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.
Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.
Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.
WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts
While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.
both the local oxygen environment and WT1, which enhances KDR (show KDR ELISA Kits) expression, contribute to sex-specific Sox9 (show SOX9 ELISA Kits) expression in developing murine gonads
The authors show that the posthepatic mesenchymal plate coelomic epithelium gives rise to a mesenchyme that populates the pleuroperitoneal folds isolating the pleural cavities before the migration of the somitic myoblasts. This process fails when Wt1 is deleted from this area.
Study reveals a novel role for Wt1 in early mammalian development and identifies proteases as critical mediators of the maternal-embryonic interaction. Data also suggest that the role of Wt1 in regulating fertility is conserved in mammals.
WT1 is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 (show SF1 ELISA Kits) expression. Without Wt1, the expression of Sf1 (show SF1 ELISA Kits) was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.
study provides novel insights into the role of WT1 and GATA4 (show GATA4 ELISA Kits) during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development
WT1 regulates reporter gene expression through interaction with 3' UTR (show UTS2R ELISA Kits)-binding sites
These results indicate that Osr1 (show OSR1 ELISA Kits) and Wt1 act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.
Wt1 regulates the development of FLC.
WT1 stimulates IGFBP5 (show IGFBP5 ELISA Kits) transcription in developing murine kidney.
Over expression of miR (show MLXIP ELISA Kits)-206 promotes podocyte injury via downregulation of WT1, which provides a new pathogenic mechanism for Focal segmental glomerulosclerosis and miR (show MLXIP ELISA Kits)-206 may be a potential therapeutic target.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Wilms tumor protein
, amino-terminal domain of EWS
, last three zinc fingers of the DNA-binding domain of WT1
, Chick Wilm's tumour protein
, Wilms tumor 1
, Wilms tumor protein homolog A
, Wilms tumor protein homolog
, Wilms tumor suppressor protein 1b
, Wilm's tumor suppressor
, Wilms tumor protein homolog B