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WT1 interference with Wnt (show WNT2 ELISA Kits) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.
The findings of the present study indicate that all females with SRNS-FSGS (show ACTN4 ELISA Kits) should be screened for WT1 gene mutation to diagnose whether they have FS for possible gonadectomy.
Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences in DNA binding and altered responses to epigenetic cytosine modifications.
Sequence variants in NPHS4 were identified in families with CRB2-related syndrome.
WT1 modulates Akt (show AKT1 ELISA Kits)/JNK (show MAPK8 ELISA Kits) signaling pathway mediated autophagy by controlling the expression of growth arrest-specific 1 (Gas1 (show GAS1 ELISA Kits)).
WT1 knock-down gave a corresponding decrease in QPRT (show QPRT ELISA Kits) gene and protein expression. Chromatin-immunoprecipitation revealed WT1 binding to a conserved site in the first intron of the QPRT (show QPRT ELISA Kits) gene.
WT1 helps to differentiate Wilms' tumour from other paediatric renal tumours. It may help in differentiating the two subgroups of Wilms' tumour which have distinct molecular pathogenesis and biological behaviour, however, further prospective studies are required for validation of this hypothesis.
a high WT1 mutation rate was observed in this group of steroid-resistant nephrotic syndrome patients
Predictive value of pretransplantation molecular minimal residual disease assessment by WT1 gene expression in FLT3 (show FLT3 ELISA Kits)-positive acute myeloid leukemia (show BCL11A ELISA Kits).
Wilms' tumor 1 is expressed in endometrial intra-epithelial neoplasia. Cellular endometrial intra-epithelial neoplasia Wilms' tumor 1 positivity was 100% and vascular Wilms' tumor 1 positivity was 85%. The endometrial adenocarcinoma group had 67% cellular Wilms' tumor 1 positivity and 73% vascular positivity.
WT1 localizes to the cytoplasm and mirn16-1 is decreased in nephrotic syndrome
Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.
Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.
WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts
WT1 stimulates IGFBP5 (show IGFBP5 ELISA Kits) transcription in developing murine kidney.
Over expression of miR (show MLXIP ELISA Kits)-206 promotes podocyte injury via downregulation of WT1, which provides a new pathogenic mechanism for Focal segmental glomerulosclerosis and miR (show MLXIP ELISA Kits)-206 may be a potential therapeutic target.
by targeting WT1, miR743a suppresses the proliferation of MM cells in vitro, and probably possesses vital functions in kidney development and kidneyassociated diseases.
To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors
miR (show MLXIP ELISA Kits)-125a is a regulatory molecule that suppresses WT1 expression via a direct interaction with the 3'UTR (show UTS2R ELISA Kits) of WT1 mRNA and miR (show MLXIP ELISA Kits)-125a knockout mice induce myeloproliferative disease (MPD (show MVD ELISA Kits)) and urogenital abnormalities
The analysis presented here demonstrates that WT1 regulates a broad set of genes, and almost 50% of the top 200 podocyte-specific genes-as defined in the GUDMAP gene expression atlas-were bound by WT1.
During normal heart development, spatio-temporal differences in contribution of WT-1 and Tcf21 (show TCF21 ELISA Kits)-LacZ (show GLB1 ELISA Kits) + cells to right versus left ventricular myocardium occur parallel to myocardial thickening.
Wt1 is essential for normal development at all kidney developmental stages under study.
Wt1 expression levels in podocytes regulate Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling through modulating the endocytic fate of LRP6 (show LRP6 ELISA Kits), and this indicates a potential target for the therapy of CKD.
The results suggest a possible role for Wt1 in cardiac vessel formation in development and disease.
While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Wilms tumor 1
, Wilms tumor protein homolog A
, Wilms tumor protein homolog
, Wilms tumor protein
, amino-terminal domain of EWS
, last three zinc fingers of the DNA-binding domain of WT1
, Wilm's tumor suppressor
, Wilms tumor protein homolog B
, Chick Wilm's tumour protein
, Wilms tumor suppressor protein 1b