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analysis of differential role of Axin RGS (show PITX2 ELISA Kits) domain function in Wnt (show WNT2 ELISA Kits) signaling during anteroposterior patterning and maternal axis formation
APC (show APC ELISA Kits) and Axin are involved in the Wnt (show WNT2 ELISA Kits) pathway
Axin binds directly to the export factor CRM1 (show XPO1 ELISA Kits) in the presence of RanGTP
Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK (show PTPRK ELISA Kits)(e1)-RSPO3 (show RSPO3 ELISA Kits)(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT (show WNT2 ELISA Kits) blockade by the porcupine (show PORCN ELISA Kits) inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT (show WNT2 ELISA Kits) pathway inhibitor AXIN1, with consequent protein loss.
role in the formation of degradasomes and degradation of beta-catenin (show CTNNB1 ELISA Kits) induced by the TNKSi G007-LK in colorectal cancer cells
VDR (show CYP27B1 ELISA Kits) is important for the maintenance of physiological level of Axin1
RUNX1 (show RUNX1 ELISA Kits) and AXIN1 proteins are strongly correlated in ER(-) tumors as well.
Mutagenesis and binding studies using the bivalent TNKS (show TNKS ELISA Kits) binding domain of Axin1 demonstrate that only certain ankyrin repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS (show TNKS ELISA Kits) ankyrin repeat conformations modulated by Axin1 interaction.
LGALS3 (show LGALS3 ELISA Kits) and AXIN1 genes affect tumor sizes and the mucinous component via Wnt (show WNT2 ELISA Kits)/ beta-catenin (show CTNNB1 ELISA Kits) pathway in the pathogenesis of colorectal cancer
The AXIN1 rs1805105 SNP was associated with small tumor size and early tumor stage in hepatocellular carcinoma.
AXIN1 is expressed in meningioma along with APC (show APC ELISA Kits) and E-cadherin (show CDH1 ELISA Kits)
Data show that poly(ADP-ribose) polymerase (PARP (show PARP1 ELISA Kits)) enzyme Tankyrase (TNKS (show TNKS ELISA Kits)) inhibition in colon cancer cells decreases beta-catenin (show CTNNB1 ELISA Kits) signaling at the level of both Axin and APC2.
Cancer point mutations in the scaffold protein (show HOMER1 ELISA Kits) Axin derail Wnt (show WNT2 ELISA Kits) signaling and promote tumor growth in vivo through a gain-of-function mechanism.
Axin-1 is critical for spindle organization and cell cycle progression during meiotic maturation in mouse oocytes.
Axin1 promotes dendritic spine stabilization through Cdc42 (show CDC42 ELISA Kits)-dependent cytoskeletal reorganization.
Axin1 and Axin2 (show AXIN2 ELISA Kits) do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.
Study reports that NRF2 (show NFE2L2 ELISA Kits) participates in the formation of a protein complex with Axin1/GSK-3/beta (show GSK3b ELISA Kits)-TrCP (show BTRC ELISA Kits) that is disrupted by WNT-3A (show WNT3A ELISA Kits), a prototypic canonical WNT (show WNT2 ELISA Kits) ligand, and leads to upregulation of the NRF2 (show NFE2L2 ELISA Kits) transcriptional signature.
Smurf1 (show SMURF1 ELISA Kits)-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 negatively regulates Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
This study demonistrated that Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex in mice.
results suggestg HSV-1 replication enhancement might be mediated by the axin RGS (show PITX2 ELISA Kits) domain.
an asymmetrical distribution pattern for Axin1 transcripts in 2-cell embryos.
Conditional disruption of Axin1 leads to development of liver tumors in mice.
beta-catenin1 cannot revert the ich (show ACE ELISA Kits) phenotype because it may be under the control of a GSK3beta (show GSK3b ELISA Kits)-independent mechanism that required Axin's RGS (show PITX2 ELISA Kits) domain function.
Wnt (show WNT2 ELISA Kits)/Axin/beta-catenin (show CTNNB1 ELISA Kits) pathway has a role in ventral CNS development
Overactivation of Wnt (show WNT2 ELISA Kits)/Axin1/beta-catenin (show CTNNB1 ELISA Kits) signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of lateral plate mesoderm Nodal signaling.
A dorsalization pathway that is exerted by Axin/JNK (show MAPK8 ELISA Kits) signaling and its inhibitor Aida (show AIDA ELISA Kits) during vertebrate embryogenesis, is defined.
Dab2 (show DAB2 ELISA Kits) stabilizes Axin and attenuates Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling by preventing PP1 from binding Axin
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
, axin 1, isoform 1
, axis inhibition protein 1
, axis inhibitor 1
, fused, mouse, homolog of
, protein phosphatase 1, regulatory subunit 49
, protein Fused
, GSK-3beta interacting protein rAxin