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marked reduction in the prominence of TUJ1 bundles in number, thickness, and length. Our results showed that deregulation of the planar cell polarity genes CELSR3 (show CELSR3 Proteins) and FZD3 might disrupt the enteric innervation pattern
seven-transmembrane domain receptors Celsr3 (show CELSR3 Proteins) and Fzd3, in particular, control the development of most longitudinal tracts in the central nervous system. [Review]
Our analysis showed no significant association between the rs2241802 polymorphism in FZD3 gene and neural tube defects
DNA methylation (show HELLS Proteins) aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects.
Wnt3a (show WNT3A Proteins)/Frizzled-3 signaling plays important role in regulating the proliferation and differentiation of neural crest cells and various developmental stages of melanocyte precursors.
Aberrant methylation modification of the FZD3 gene increases the risk of congenital hydrocephalus (show FOXC1 Proteins) by altering chromatin structure and disturbing gene expression.
FZD3 signaling sensitized peripheral sensory neurons in pain hypersensitivity.
clinical significance of frizzled homolog 3 protein in colorectal cancer patients
Genetic variants of the FZD3 gene may affect susceptibility to schizophrenia in Chinese Han and Va populations.
This study found a significant association between schizophrenia and the FZD3 gene in single nucleotide polymorphisms and haplotype analyses.
loss of Fzd3 induces severe malformations of the developing eye and this defect is phenocopied by loss of the activated leukocyte cell adhesion molecule (Alcam (show ALCAM Proteins)).
Frizzled3 is required to shape the pattern of RBC (show CACNA1C Proteins) somas and dendrites, and the structural and functional connectivity between rods and RBCs (show SSU1 Proteins). Our results highlight novel functions for Fzd3 in regulating retinal development.
Temporal and spatial expression profiles of Frizzled 3 in the ovary during the estrous cycle has been reported.
Celsr3 (show CELSR3 Proteins) and Fzd3 enable immature neurons to respond to Wnt7 (show WNT7B Proteins), upregulate Jag1 (show JAG1 Proteins) and thereby facilitate feedback signals that tune the timing of neural progenitor cell fate decisions via Notch (show NOTCH1 Proteins) activation.
This study demonstrated that Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development.
In Fz3(-/-) limbs, dorsal axons stall at a precise location in the nerve plexus, and, in contrast to the phenotypes of several other axon path-finding mutants, Fz3(-/-) dorsal axons do not reroute to other trajectories
Fz3 and Fz6 (show FZD6 Proteins) have partly interchangeable roles in tissue polarity signaling for epithelial orientation and axon growth and guidance
The first signal, controlled by cadherin, EGF (show EGF Proteins)-like, laminin G-like, seven-pass, G-type receptor (Celsr) 2 (show CELSR2 Proteins), Celsr3 (show CELSR3 Proteins), Frizzled3 (Fzd3) and Van Gogh (show VANGL2 Proteins) like2 (Vangl2 (show VANGL2 Proteins)) organizes multicilia in individual cells (single-cell polarity)
Celsr2 (show CELSR2 Proteins)-3 and Fzd3 regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial core planar cell polarity, and require interacting partners other than Vangl1 (show Vangl1 Proteins)-2 that remain to be identified.
Several central nervous system axon tracts require Fz3 function as early as embryonic day 11.5, and that Fz3 is required for pathfinding by dopaminergic and serotonergic axons in the brain and by a subset of optic tract axons.
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia.
frizzled 3, seven transmembrane spanning receptor
, frizzled homolog 3
, frizzled homolog 3 (Drosophila)
, frizzled 3
, frizzled family receptor 3