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Browse our GPBAR1 Proteins (GPBAR1)

Full name:
G Protein-Coupled Bile Acid Receptor 1 Proteins (GPBAR1)
On www.antibodies-online.com are 3 G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) Proteins from 2 different suppliers available. Additionally we are shipping GPBAR1 Antibodies (100) and GPBAR1 Kits (12) and many more products for this protein. A total of 121 GPBAR1 products are currently listed.
Synonyms:
BG37, CD344, EVR1, FEVR, Fz-4, Fz4, FZD4S, FzE4, Gpbar1, GPCR, GPCR19, GPR131, hFz4, M-BAR, MGC84403, Tgr5
list all proteins Gene Name GeneID UniProt
GPBAR1 8322 Q9ULV1
GPBAR1 227289 Q80SS6
Rat GPBAR1 GPBAR1 338443 Q80T02

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GPBAR1 Proteins (GPBAR1) by Origin

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Human G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. this is the first report of bile acid derivatives able to antagonize GPBAR1 and and farnesoid X receptor (show xpr1 Proteins) (FXR (show NR1H4 Proteins)) modulatory activity.

  2. Two were novel mutations: p.E134* and p.T503fs of FZD4 (show FZD4 Proteins) lead to the loss of FZD4 (show FZD4 Proteins) activity.

  3. Letter: FZD4 (show FZD4 Proteins)+ and FZD4 (show FZD4 Proteins)- melanocytes were significantly lower in hair follicles of patients with rhododenol-induced leukoderma.

  4. These findings identify TGR5 as a suppressor of gastric cancer cell proliferation and migration

  5. Because elevated levels of circulatory LPS (show IRF6 Proteins) may contribute to the development of insulin (show INS Proteins) resistance, the results from this study suggest that bile acids through the activation of TGR5 may have a role in the development of insulin (show INS Proteins) resistance as well.

  6. TGR5 is a mediator of bile acid-induced cholangiocyte proliferation and protects cholangiocytes from apoptosis but may trigger proliferation and apoptosis resistance in malignantly transformed cholangiocytes, promoting cholangiocarcinoma.

  7. These structural, biophysical and cellular data, map Fz4 (show FZD4 Proteins) and putative Lrp5 (show LRP5 Proteins)/6 binding sites to distinct patches on Norrin (show NDP Proteins), and reveal a GAG binding site spanning Norrin (show NDP Proteins) and Fz4 (show FZD4 Proteins) cysteine-rich domain.

  8. Collectively, these data suggest the involvement of TGR5 in PLD and that TGR5 targeting in cystic cholangiocytes may have therapeutic potential.

  9. The relatively high prevalence of the p.[P33S(;)P168S] variant in ROP (show STXBP1 Proteins) (retinopathy of prematurity) and intrauterine growth restriction suggests that it also may be a marker for increased risk of developing ROP (show STXBP1 Proteins) and preterm birth.

  10. Mutations of FZD4 (show FZD4 Proteins) accounted for the largest proportion, which could be directly applied to the testing strategy to start with screening for FZD4 (show FZD4 Proteins) mutations.

Mouse (Murine) G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. The results suggest that TGR5 activation mediates cross-talk between alpha- and beta-cells by switching from glucagon (show GCG Proteins) to GLP-1 (show GCG Proteins) to restore beta- cell mass and function under hyperglycemic conditions.

  2. TGR5 is an important mediator of bile acid-induced cholangiocyte proliferation in vivo and in vitro. Furthermore, TGR5 protects cholangiocytes from death receptor-mediated apoptosis.

  3. miR (show MLXIP Proteins)-26a is a target gene of bile acid receptor (show NR1H4 Proteins) GPBAR-1/TGR5

  4. Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

  5. Data show that the action of bile acids on -like peptide-1 (GLP-1 (show GCG Proteins)) secretion is predominantly mediated by G protein-coupled bile acid receptor (show NR1H4 Proteins) GPBAR1 (TGR5) located on the basolateral L-cell membrane.

  6. TGR5 appears to be crucial for protecting the regenerating liver from bile acid overload.

  7. Activation of TGR5 alleviates neuroinflammation and improves outcome in hepatic encephalopathy.

  8. XGB (show GTPBP4 Proteins) increases BMR by TGR5-dependent mechanisms in mice

  9. GPBAR1 plays a role in secondary bile acid induced vasodilation via reglation of cystathionine gamma-lyase. The GPBAR1/CSE pathway might contribute to endothelial dysfunction and hyperdynamic circulation in liver cirrhosis.

  10. these studies reveal a signaling pathway downstream of TGR5 that modulates chemokine (show CCL1 Proteins) expression in response to high-fat diet

Cow (Bovine) G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. TGR5 agonism induces NO production via Akt (show AKT1 Proteins) activation and intracellular Ca(2 (show CA2 Proteins)+) increase in vascular endothelial cells, and this function inhibits monocyte adhesion in response to inflammatory stimuli.

Rabbit G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. TGR5 has been linked to signaling pathways involved in metabolism, cell survival, proliferation and apoptosis, which suggest a possible role of TGR5 in cancer development.

GPBAR1 Protein Profile

Protein Summary

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with GPBAR1

  • G protein-coupled bile acid receptor 1 (gpbar1)
  • G protein-coupled bile acid receptor 1 (GPBAR1)
  • frizzled family receptor 4 (FZD4)
  • G protein-coupled bile acid receptor 1 (Gpbar1)
  • G protein-coupled receptor (TGR5)
  • BG37 protein
  • CD344 protein
  • EVR1 protein
  • FEVR protein
  • Fz-4 protein
  • Fz4 protein
  • FZD4S protein
  • FzE4 protein
  • Gpbar1 protein
  • GPCR protein
  • GPCR19 protein
  • GPR131 protein
  • hFz4 protein
  • M-BAR protein
  • MGC84403 protein
  • Tgr5 protein

Protein level used designations for GPBAR1

G protein-coupled bile acid receptor 1 , G-protein coupled bile acid receptor BG37 , WNT receptor frizzled-4 , frizzled 4, seven transmembrane spanning receptor , frizzled homolog 4 , frizzled-4 , G-protein coupled bile acid receptor 1 , G-protein coupled receptor GPCR19 , hBG37 , hGPCR19 , membrane bile acid receptor , membrane-type receptor for bile acids , G protein-coupled receptor TGR5 , G protein-coupled receptor , M-BAR

GENE ID SPECIES
447779 Xenopus laevis
488521 Canis lupus familiaris
697937 Macaca mulatta
741111 Pan troglodytes
8322 Homo sapiens
151306 Homo sapiens
227289 Mus musculus
338443 Rattus norvegicus
317756 Bos taurus
100009346 Oryctolagus cuniculus
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