Browse our LLGL1 Proteins (LLGL1)

Full name:
Lethal Giant Larvae Homolog 1 (Drosophila) Proteins (LLGL1)
On are 3 Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1) Proteins from 2 different suppliers available. Additionally we are shipping LLGL1 Antibodies (21) and many more products for this protein. A total of 26 LLGL1 products are currently listed.
AI325176, DLG4, HUGL, HUGL-1, HUGL1, Lgl1, LLGL, LLGL1, Llglh, Mgl1, Rgl1
list all proteins Gene Name GeneID UniProt
LLGL1 3996 Q15334
LLGL1 16897 Q80Y17
Rat LLGL1 LLGL1 54265 Q8K4K5

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LLGL1 Proteins (LLGL1) by Origin

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More Proteins for LLGL1 Interaction Partners

Human Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1) interaction partners

  1. Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2 (show CNTNAP2 Proteins)-IgG or LGI1 (show LGI1 Proteins)-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1 (show LGI1 Proteins)-IgG.

  2. Reduced expression of Hugl 1 predicts poor survival in lung SqCC patients. The expression of Hugl 1 was inversely correlated with both overall survival rate and tumor stage.

  3. Our results support the growing appreciation that the tumour regulatory functions of Scribble, and other polarity protein family members, are context dependent.

  4. this study provides the evidence that Hugl-1 inhibits glioma cell growth in intracranial model of nude mice, suggesting that Hugl-1 might be a potential tumor target for glioma therapy.

  5. Lgl1 (show CRISPLD2 Proteins) has a role in inhibiting glioblastoma

  6. PTEN loss leads to the phosphorylation and inactivation of Lgl by atypical protein kinase C (show PRKCZ Proteins) in glioblastoma cells.

  7. Suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo.

  8. inactivation of Llgl1 enhances hematopoietic stem cells self-renewal and fitness and is associated with unfavorable outcome in human acute myeloid leukemia (show BCL11A Proteins)

  9. Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control.

  10. Preservation of HUGL-1 expression in pancreatic adenocarcinoma is a good prognostic factor that contributes to a better overall survival

Mouse (Murine) Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1) interaction partners

  1. Ablation of Llgl1 gene Results in Severe Brain Malformation.

  2. Lgl1 (show Klra7 Proteins) is required for the development of the olfactory bulb.

  3. results suggest that neural stem cell-mediated neuron and glia production is tightly regulated through the concerted interplay of sequential Lgl1 (show Klra7 Proteins)-dependent global and cell intrinsic mechanisms.

  4. These results reveal a novel role for Lgl-1 (show Klra7 Proteins) in the regulation of virus-specific T-cell responses and antitumor immunity.

  5. Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1 (show Klra7 Proteins))-Pax2 (show PAX2 Proteins) protein knockout embryos.

  6. Lgl1 (show Klra7 Proteins) forms two distinct complexes in vivo, Lgl1 (show Klra7 Proteins)-NMIIA and Lgl1 (show Klra7 Proteins)-Par6alpha (show PARD6A Proteins)-aPKCzeta (show PRKCZ Proteins), and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (show Klra7 Proteins).

  7. Collectively these findings indicate that Lgl1 (show Klra7 Proteins) regulates the polarity of migrating cells by controlling the assembly state of NMII-A, its cellular localization, and focal adhesion assembly.

  8. This is the first study to demonstrate the involvement of Dlg1 (show DLG1 Proteins), Scrib, and Lgl1 (show Klra7 Proteins) in a mouse with ocular adenocarcinoma and the simultaneous involvement of these proteins in the same cancer.

  9. Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor.

  10. mgl-1 mRNA is developmentally expressed in CNS, craniofacial region, eyes, limbs, and the gut (show GUSB Proteins)

LLGL1 Protein Profile

Protein Summary

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.

Alternative names and synonyms associated with LLGL1

  • discs, large homolog 4 (Drosophila) (DLG4)
  • lethal giant larvae homolog 1 (Drosophila) (LLGL1)
  • lethal giant larvae homolog 1 (Drosophila) (Llgl1)
  • AI325176 protein
  • DLG4 protein
  • HUGL protein
  • HUGL-1 protein
  • HUGL1 protein
  • Lgl1 protein
  • LLGL protein
  • LLGL1 protein
  • Llglh protein
  • Mgl1 protein
  • Rgl1 protein

Protein level used designations for LLGL1

disks large homolog 4 , lethal(2) giant larvae protein homolog 1 , human homolog to the D-lgl gene protein , LLGL , mgl-1 , mlgl , rgl-1

714273 Macaca mulatta
3996 Homo sapiens
489538 Canis lupus familiaris
781865 Bos taurus
16897 Mus musculus
54265 Rattus norvegicus
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