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Reduced expression of Hugl 1 predicts poor survival in lung SqCC patients. The expression of Hugl 1 was inversely correlated with both overall survival rate and tumor stage.
Our results support the growing appreciation that the tumour regulatory functions of Scribble, and other polarity protein family members, are context dependent.
this study provides the evidence that Hugl-1 inhibits glioma cell growth in intracranial model of nude mice, suggesting that Hugl-1 might be a potential tumor target for glioma therapy.
Lgl1 (show CRISPLD2 Proteins) has a role in inhibiting glioblastoma
PTEN loss leads to the phosphorylation and inactivation of Lgl by atypical protein kinase C (show PRKCZ Proteins) in glioblastoma cells.
Suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo.
inactivation of Llgl1 enhances hematopoietic stem cells self-renewal and fitness and is associated with unfavorable outcome in human acute myeloid leukemia (show BCL11A Proteins)
Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control.
Preservation of HUGL-1 expression in pancreatic adenocarcinoma is a good prognostic factor that contributes to a better overall survival
Hugl-1 can act as a tumour suppressor in Drosophila and thus is the functional homologue of lgl
Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1 (show Klra7 Proteins))-Pax2 (show PAX2 Proteins) protein knockout embryos.
Lgl1 (show Klra7 Proteins) forms two distinct complexes in vivo, Lgl1 (show Klra7 Proteins)-NMIIA and Lgl1 (show Klra7 Proteins)-Par6alpha (show PARD6A Proteins)-aPKCzeta (show PRKCZ Proteins), and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (show Klra7 Proteins).
Collectively these findings indicate that Lgl1 (show Klra7 Proteins) regulates the polarity of migrating cells by controlling the assembly state of NMII-A, its cellular localization, and focal adhesion assembly.
This is the first study to demonstrate the involvement of Dlg1 (show DLG1 Proteins), Scrib, and Lgl1 (show Klra7 Proteins) in a mouse with ocular adenocarcinoma and the simultaneous involvement of these proteins in the same cancer.
Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor.
mgl-1 mRNA is developmentally expressed in CNS, craniofacial region, eyes, limbs, and the gut (show GUSB Proteins)
results reveal a critical role for mammalian Lgl1 (show Klra7 Proteins) in regulating of proliferation, differentiation, and tissue organization and demonstrate a potential causative role of disruption of cell polarity in neoplastic transformation of neuroepithelial cells.
Early branching morphogenesis in the lung and kidney is stimulated by retinoic acid, and retinoic acid response elements in the Lgl1 (show Klra7 Proteins) promoter are identified.
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
disks large homolog 4
, lethal(2) giant larvae protein homolog 1
, human homolog to the D-lgl gene protein