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Plcb1 plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. (Review)
Unpredictable chronic mild stress mice exhibited lower nucleus accumbens (NAC (show NLRP1 ELISA Kits)) shell levels of phospholipase Cbeta.
Heightened PLCbeta1b activity observed in diseased myocardium contributes to pathology by PKCalpha (show PKCa ELISA Kits)-mediated contractile dysfunction.
inhibition of miR (show MLXIP ELISA Kits)-214 in C2C12 cells significantly enhances the protein level of PLCbeta1 and promotes C2C12 BMP-2 (show BMP2 ELISA Kits)-induced osteogenesis by targeting PLCbeta1
Results indicate that PLC (show HSPG2 ELISA Kits)-beta1 signalling in the medial prefrontal cortex is required for working memory
In pro-B-lymphoblastic cells (Ba/F3), treated with H2O2, PI-PLCbeta1b conferred resistance to cell death, promoting cell cycle progression and cell proliferation and influencing the expression of cyclin A (show CCNA2 ELISA Kits) and E.
Tnis study demonistrated that plc (show HSPG2 ELISA Kits) beta1 distribuate in mice cerebellum.
Galphaq (show GNAQ ELISA Kits)-coupled Lpar1 (show LPAR1 ELISA Kits) regulates cell proliferation and migration by activating two distinct PLC (show HSPG2 ELISA Kits)-beta isozymes, PLC (show HSPG2 ELISA Kits)-beta1 and PLC (show HSPG2 ELISA Kits)-beta2, respectively.
These findings highlight a novel pathway by which nuclear PLCs affect insulin (show INS ELISA Kits) secretion and identify PPARgamma (show PPARG ELISA Kits) as a novel molecular target of nuclear PLCs.
Demonstrate critical role of the glutamatergic system in the phenotype of the PLC (show HSPG2 ELISA Kits)-beta1 knockout mouse and highlight the role of these interconnected signalling pathways in schizophrenia-like behavioural disruption.
Dysregulation of primary PLC (show HSPG2 ELISA Kits) signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review)
Phospholipase C beta connects G protein signaling with RNA interference. (Review)
The role of PLCb1 nuclear isoform is being analyzed in relation to the cell cycle regulation, the cell differentiation, and different physiopathological pathways focusing on the importance of the nuclear localization from both molecular and clinical point of view. (Review)
Polymorphism of the PLCB4 (show PLCb4 ELISA Kits)/B1 genes might be involved in the coronary artery aneurysm pathogenesis of Kawasaki disease.
Reduction in plasma membrane PI(4,5)P2 abundance by PTPRN2 and PLCbeta1 releases the PI(4,5)P2-binding protein cofilin from its inactive membrane-associated state into the cytoplasm where it mediates actin turnover dynamics.
The rs6108160 polymorphism in the PLCB1 gene reached statistical significance after antidepressant drug use.
results show that PI-PLCbeta1 quantification in MDS (show PAFAH1B1 ELISA Kits) predicts the response to azacitidine and is associated with an increased myeloid differentiation.
one specific Egr-1 (show EGR1 ELISA Kits) binding site was identified at nt-451/-419 and PLCB1 promoter activity was increased more than 5-fold
Cholesterol regulates HERG (show KCNH2 ELISA Kits) K+ channel (show KCNC4 ELISA Kits) activation by increasing phospholipase C beta1 expression
Our data indicate that the amplification of PLCb1a expression, following treatment with kinamycin F, confers a real advantage to K562 cells viability and protects cells themselves from apoptosis.
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.
phosphoinositide-specific phospholipase C beta 1
, phospholipase C, beta 1 (phosphoinositide-specific)
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1-like
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
, phosphoinositide phospholipase C
, phosphoinositide phospholipase C-beta-1
, phospholipase C-beta-1
, phospholipase C-beta-1a
, monophosphatidylinositol phosphodiesterase
, phosphoinositidase C
, phospholipase C-I
, triphosphoinositide phosphodiesterase
, Phospholipase C-beta1