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apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (show CDK2 ELISA Kits), leading to shortening of G1 and S phases
Neural induction by Syn4 (show SNTG1 ELISA Kits) through the PKC (show PKC ELISA Kits) pathway requires inhibition of PKCdelta (show PKCd ELISA Kits) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (show PKC ELISA Kits) of the KCNE1 (show KCNE1 ELISA Kits) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (show PKC ELISA Kits) in Kv4.3 (show KCND3 ELISA Kits)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
After inhibition of the PKC/ERK signalling pathway, the effects of DOR on breast cancer were significantly attenuated in vivo and in vitro. In summary, DOR is highly expressed in breast cancer and is closely related to its progression. These results suggest that DOR may serve as a potential biomarker for the early diagnosis of breast cancer and may be a viable molecular target for therapeutic intervention.
authors found significant interactions among PRKCA, NOS3 and BDKRB2 (show BDKRB2 ELISA Kits) genotypes associated with enalapril responses.
Protein kinase C alpha (PKCalpha) is able to phosphorylate CK1delta at its C-terminally located residues S328, T329, and S370.
PKCalpha activity was effectively suppressed by the PKC inhibitor.
this study shows that the mTOR inhibitors suppression of invasion and migration of glioblastoma cells is mediated by reduction of PKC-alpha activity and downregulation of NFkappaB
PKCalpha controls HIF-1alpha (show HIF1A ELISA Kits) translation via AKT (show AKT1 ELISA Kits)-mTOR (show FRAP1 ELISA Kits) under hypoxic conditions.
Our results provide compelling evidence that glucose-induced PKCalpha/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction
Data suggest that targeted manipulation of protein kinase C (show PKC ELISA Kits) isoforms PKCalpha, PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 (show TRPC6 ELISA Kits) protein (TRPC6 (show TRPC6 ELISA Kits)) functions.
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
PKCalpha Attenuates Jagged-1 (show JAG1 ELISA Kits)-Mediated Notch (show NOTCH1 ELISA Kits) Signaling in ErbB-2 (show ERBB2 ELISA Kits)-Positive Breast Cancer to Reverse Trastuzumab Resistance
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (show SYT1 ELISA Kits) phosphorylation is an essential step in PKC (show PKC ELISA Kits)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (show PKC ELISA Kits) substrates, Munc13-1 (show UNC13A ELISA Kits) and Munc18-1 (show STXBP1 ELISA Kits).
These data indicate that LPA increases CCN2 (show CTGF ELISA Kits) expression through the activation of PKC (show PKC ELISA Kits) and PKA. Thus, the regulatory functions of the PKC (show PKC ELISA Kits) and PKA pathways are implicated in the LPA-induced increase in CCN2 (show CTGF ELISA Kits) expression
We conclude that melatonin, via modulation of PKC (show PKC ELISA Kits) and Ca(2 (show CA2 ELISA Kits)+) signaling, could potentially stimulate the Nrf2 (show NFE2L2 ELISA Kits)-mediated antioxidant response in mouse pancreatic acinar cells.
PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (show TBXA2R ELISA Kits), possibly via increased pulmonary arterial TP receptor (show TBXA2R ELISA Kits) expression.
at the functionally mature calyx of Held synapse the Ca(2 (show CA2 ELISA Kits)+)-dependent protein kinase C (show PKC ELISA Kits) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
PKC gene deletion is responsible for hair loss.
The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.
the ANG II (show AGT ELISA Kits)-dependent upregulation of renin (show REN ELISA Kits) in the collecting duct depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB (show CREB1 ELISA Kits) pathway
PKC (show PKC ELISA Kits) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (show GRM5 ELISA Kits) and AMPA (show GRIA3 ELISA Kits)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (show CA2 ELISA Kits)+-sensitivity, structure and kinetics are brought about through PKC (show PKC ELISA Kits) phosphorylation of cardiac troponin T (show TNNT2 ELISA Kits).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 ELISA Kits) expression by NF-kappaB (show NFKB1 ELISA Kits)-MT1-MMP (show MMP14 ELISA Kits)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (show ASS1 ELISA Kits) Ser (show SIGLEC1 ELISA Kits)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (show TUBB ELISA Kits).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (show Akap6 ELISA Kits)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (show CDK7 ELISA Kits) Calpha (show PRKACA ELISA Kits)
By regulating VEGFR2 (show KDR ELISA Kits) expression and activation, PKC-epsilon (show PRKCE ELISA Kits) expression is critical for activation of Akt (show AKT1 ELISA Kits) and eNOS (show NOS3 ELISA Kits) by VEGF (show VEGFA ELISA Kits) and contributes to VEGF (show VEGFA ELISA Kits)-stimulated Erk (show MAPK1 ELISA Kits) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (show CA2 ELISA Kits)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (show PPP1R14A ELISA Kits) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (show ESR1 ELISA Kits).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha