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apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (show CDK2 ELISA Kits), leading to shortening of G1 and S phases
Neural induction by Syn4 (show SNTG1 ELISA Kits) through the PKC (show PKC ELISA Kits) pathway requires inhibition of PKCdelta (show PKCd ELISA Kits) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (show PKC ELISA Kits) of the KCNE1 (show KCNE1 ELISA Kits) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (show PKC ELISA Kits) in Kv4.3 (show KCND3 ELISA Kits)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
PKCalpha Attenuates Jagged-1 (show JAG1 ELISA Kits)-Mediated Notch (show NOTCH1 ELISA Kits) Signaling in ErbB-2 (show ERBB2 ELISA Kits)-Positive Breast Cancer to Reverse Trastuzumab Resistance
we suggest that PKCA tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.
Prolonged membrane association/activation of PKCalpha is seen in self-renewing epithelium of the intestine, cervix, and skin.
RNA sequencing identified a novel ATPase (show DNAH8 ELISA Kits), Ca2 (show CA2 ELISA Kits)+ transporting, plasma membrane 4(ATP2B4 (show ATP2B4 ELISA Kits))-protein kinase C-alpha (PRKCA) fusion transcript.
InB may exhibit growth-inhibitory activity through the activation of PKCalpha, followed by an increase in NFAT (show NFATC1 ELISA Kits) transactivation ability.
High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression.
Data show that bisindolylmaleimides (BIMs) Ro 31-8220 also blocks activity of the solute carrier organic cation transporter 1 (OCT1), involved in uptake of marketed drugs in the liver, in a protein kinase C (PKC (show PKC ELISA Kits))-independent manner.
this study identified PKC as the kinase that phosphorylates a specific site in the linker region of PACSIN2 (show PACSIN2 ELISA Kits).
results indicate that PKC-mediated cortactin (show CTTN ELISA Kits) phosphorylation might be implicated in the maintenance of growth cone
These data indicate that LPA increases CCN2 (show CTGF ELISA Kits) expression through the activation of PKC (show PKC ELISA Kits) and PKA. Thus, the regulatory functions of the PKC (show PKC ELISA Kits) and PKA pathways are implicated in the LPA-induced increase in CCN2 (show CTGF ELISA Kits) expression
We conclude that melatonin, via modulation of PKC (show PKC ELISA Kits) and Ca(2 (show CA2 ELISA Kits)+) signaling, could potentially stimulate the Nrf2 (show NFE2L2 ELISA Kits)-mediated antioxidant response in mouse pancreatic acinar cells.
PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (show TBXA2R ELISA Kits), possibly via increased pulmonary arterial TP receptor (show TBXA2R ELISA Kits) expression.
at the functionally mature calyx of Held synapse the Ca(2 (show CA2 ELISA Kits)+)-dependent protein kinase C (show PKC ELISA Kits) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
PKC gene deletion is responsible for hair loss.
The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.
the ANG II (show AGT ELISA Kits)-dependent upregulation of renin (show REN ELISA Kits) in the collecting duct depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB (show CREB1 ELISA Kits) pathway
role for PKCalpha in the regulation of ECM (show MMRN1 ELISA Kits) structure and deposition during skin wound healing.
A dynamic PKC (show PKC ELISA Kits) phosphorylation/de-phosphorylation cycle of Munc18-1 (show STXBP1 ELISA Kits) drives short-term enhancement of transmitter release during post-tetanic potentiation.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (show CA2 ELISA Kits)+-sensitivity, structure and kinetics are brought about through PKC (show PKC ELISA Kits) phosphorylation of cardiac troponin T (show TNNT2 ELISA Kits).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 ELISA Kits) expression by NF-kappaB (show NFKB1 ELISA Kits)-MT1-MMP (show MMP14 ELISA Kits)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (show ASS1 ELISA Kits) Ser (show SIGLEC1 ELISA Kits)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (show TUBB ELISA Kits).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (show Akap6 ELISA Kits)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (show CDK7 ELISA Kits) Calpha (show PRKACA ELISA Kits)
By regulating VEGFR2 (show KDR ELISA Kits) expression and activation, PKC-epsilon (show PRKCE ELISA Kits) expression is critical for activation of Akt (show AKT1 ELISA Kits) and eNOS (show NOS3 ELISA Kits) by VEGF (show VEGFA ELISA Kits) and contributes to VEGF (show VEGFA ELISA Kits)-stimulated Erk (show MAPK1 ELISA Kits) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (show CA2 ELISA Kits)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (show PPP1R14A ELISA Kits) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (show ESR1 ELISA Kits).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha