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apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (show CDK2 ELISA Kits), leading to shortening of G1 and S phases
Neural induction by Syn4 (show SNTG1 ELISA Kits) through the PKC (show PKC ELISA Kits) pathway requires inhibition of PKCdelta (show PKCd ELISA Kits) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (show PKC ELISA Kits) of the KCNE1 (show KCNE1 ELISA Kits) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (show PKC ELISA Kits) in Kv4.3 (show KCND3 ELISA Kits)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
In polymorphism PRKCA rs9892651, HDL (show HSD11B1 ELISA Kits)-C levels were lower in carriers of CC and TC genotypes that were more frequent in current-wheezers Vs TT genotype (52.2 and 52.7 Vs 55.2 mg/dl, p-value = 0.042 and p-value for trend = 0.02).
Ca(2+)-PKC-MARCKS-PIP2-PI3K-PIP3 system functions as an activation module in vitro
phosphorylation of TIMAP on Ser331 by PKC represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM dephosphorylation
PKCalpha-GSK3beta-NF-kappaB (show NFKB1 ELISA Kits) signaling pathway involvement in TRAIL-induced apoptosis
Curcumin inhibited phorbol ester-induced membrane translocation of protein kinase C-epsilon (PKCepsilon (show PRKCE ELISA Kits)) mutants, in which the epsilonC1 domain was replaced with alphaC1, but not the protein kinase C-alpha (PKCalpha) mutant in which alphaC1 was replaced with the epsilonC1 domain, suggesting that alphaC1 is a determinant for curcumin's inhibitory effect.
a library of FRET sensors to monitor these transient complexes, specifically examining weak interactions between the catalytic domain of protein kinase (show CDK7 ELISA Kits) Calpha (show PRKACA ELISA Kits) and 14 substrate peptides.
calpain and protein kinase (show CDK7 ELISA Kits) Calpha (show PRKACA ELISA Kits) abnormal release promotes a constitutive release of matrix metalloproteinase 9 (show MMP9 ELISA Kits) in peripheral blood mononuclear cells from cystic fibrosis (show S100A8 ELISA Kits) patients
protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein-mediated signaling turn-off.
Protein kinase C (show PKC ELISA Kits) enhances the swelling-induced chloride current in human atrial myocytes.
these results confirm the correlation between AXL (show AXL ELISA Kits) and PKCalpha, and suggest PKCalpha-AXL (show AXL ELISA Kits) signaling may be a treatment target, particularly in malignant cancer cells.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (show SYT1 ELISA Kits) phosphorylation is an essential step in PKC (show PKC ELISA Kits)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (show PKC ELISA Kits) substrates, Munc13-1 (show UNC13A ELISA Kits) and Munc18-1 (show STXBP1 ELISA Kits).
These data indicate that LPA increases CCN2 (show CTGF ELISA Kits) expression through the activation of PKC (show PKC ELISA Kits) and PKA. Thus, the regulatory functions of the PKC (show PKC ELISA Kits) and PKA pathways are implicated in the LPA-induced increase in CCN2 (show CTGF ELISA Kits) expression
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
We conclude that melatonin, via modulation of PKC (show PKC ELISA Kits) and Ca(2 (show CA2 ELISA Kits)+) signaling, could potentially stimulate the Nrf2 (show NFE2L2 ELISA Kits)-mediated antioxidant response in mouse pancreatic acinar cells.
PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (show TBXA2R ELISA Kits), possibly via increased pulmonary arterial TP receptor (show TBXA2R ELISA Kits) expression.
at the functionally mature calyx of Held synapse the Ca(2 (show CA2 ELISA Kits)+)-dependent protein kinase C (show PKC ELISA Kits) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
PKC gene deletion is responsible for hair loss.
The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.
PKC (show PKC ELISA Kits) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (show GRM5 ELISA Kits) and AMPA (show GRIA3 ELISA Kits)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (show CA2 ELISA Kits)+-sensitivity, structure and kinetics are brought about through PKC (show PKC ELISA Kits) phosphorylation of cardiac troponin T (show TNNT2 ELISA Kits).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 ELISA Kits) expression by NF-kappaB (show NFKB1 ELISA Kits)-MT1-MMP (show MMP14 ELISA Kits)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (show ASS1 ELISA Kits) Ser (show SIGLEC1 ELISA Kits)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (show TUBB ELISA Kits).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (show Akap6 ELISA Kits)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (show CDK7 ELISA Kits) Calpha (show PRKACA ELISA Kits)
By regulating VEGFR2 (show KDR ELISA Kits) expression and activation, PKC-epsilon (show PRKCE ELISA Kits) expression is critical for activation of Akt (show AKT1 ELISA Kits) and eNOS (show NOS3 ELISA Kits) by VEGF (show VEGFA ELISA Kits) and contributes to VEGF (show VEGFA ELISA Kits)-stimulated Erk (show MAPK1 ELISA Kits) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (show CA2 ELISA Kits)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (show PPP1R14A ELISA Kits) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (show ESR1 ELISA Kits).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha