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E2F transcription factor 1 (E2F1 (show E2F1 ELISA Kits)) downregulated micrRNA miR (show MLXIP ELISA Kits)-519d directly and miR (show MLXIP ELISA Kits)-519d downregulated Ras homolog gene family member C (RhoC) directly.
These results reveal a previously unidentified pathway downstream of RHO that regulates the polarity of migrating cells through Golgi reorientation in a FAM65A-, CCM3- and MST3- and MST4-dependent manner.
During the process of epithelial-mesenchymal transition in A549 cells induced by TGF-beta1 (show TGFB1 ELISA Kits), upregulated RhoC protein and RhoC activity were detected, which was associated with the enhanced invasive capability of the cells in vitro.
RhoC downregulation may inhibit the proliferation, drug resistance, invasion and migration of ovarian cancer stem cells.
Downregulation of RHOC inhibited cholangiocellular carcinoma cells invasion and migration partially via inhibition of matrix metalloproteinase 2 (show MMP2 ELISA Kits), 3 and 9 expression. RHOC also modulated the expression of several epithelial-mesenchymal transition (EMT (show ITK ELISA Kits))-associated proteins
RT-PCR and Western blot assays demonstrated that miR (show MLXIP ELISA Kits)-372 transfection reduced the expression of RhoC.
Significant associations between ROCK1 (show ROCK1 ELISA Kits), ROCK2 (show ROCK2 ELISA Kits), RhoA (show RHOA ELISA Kits) and RhoC gene polymorphisms and systemic sclerosis were demonstrated.
study has identified several new proteins like RHOC, DLG5, UGDH (show UGDH ELISA Kits), TMOD3 (show TMOD3 ELISA Kits) in addition to known chemoresistance associated proteins in non-small cell lung carcinoma.
the oncogene (show RAB1A ELISA Kits) RhoC, a driver of metastatic potential, modulates glutamine (show GFPT1 ELISA Kits) and N-acetylaspartate metabolism in Inflammatory Breast Cancer cells in vitro, revealing a novel role for RhoC as a regulator of tumor cell metabolism that extends beyond its well known role in cytoskeletal rearrangement.
The knockdown of RhoC protein decreased the proliferation rate of the parental and the IE1-expressing glioblastoma cells.
Inhibition of ovarian epithelial carcinoma tumorigenesis and progression by miR106b proceeds through the RhoC pathway.
RHOC and RAB38 are dispensable for osteoclast function.
A p27(kip1 (show CDKN1B ELISA Kits))-binding protein, p27RF-Rho (show LAMTOR1 ELISA Kits), promotes cancer metastasis via activation of RhoA (show RHOA ELISA Kits) and RhoC.
We found that both RhoA and RhoC, but not RhoB, were required for initiation of centrosome duplication, and overactivation of RhoA, as well as RhoC, but not RhoB, promoted centrosome duplication and centrosome amplification.
RhoC has a role in metastasis of lung cancer in mice
loss of RhoC does not affect tumor development but decreases tumor cell motility and metastatic cell survival leading to a drastic inhibition of metastasis
RhoC promotes melanoma progression via separate mechanisms that regulate the PI3K/Akt (show AKT1 ELISA Kits) pathway and the ROCK signaling pathway.
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
ras homolog gene family, member C
, rho-related GTP-binding protein RhoC
, RAS-related homolog 9
, oncogene RHO H9
, rho cDNA clone 9
, rhoC GTPase
, small GTP binding protein RhoC
, aplysia ras-related homolog 9 (RhoC)
, ras homolog 9 (RhoC)
, silica-induced gene 61 protein
, GTP-binding protein
, GTPase cRhoC