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Browse our SFRP5 Proteins (SFRP5)

Full name:
Secreted Frizzled-Related Protein 5 Proteins (SFRP5)
On are 12 Secreted Frizzled-Related Protein 5 (SFRP5) Proteins from 5 different suppliers available. Additionally we are shipping SFRP5 Antibodies (74) and SFRP5 Kits (39) and many more products for this protein. A total of 128 SFRP5 products are currently listed.
AI605071, crescent, D144, frp1, frp5, SARP3, sFRP-5, sfrp5, XsFRP5, zgc:101849
list all proteins Gene Name GeneID UniProt
SFRP5 6425 Q5T4F7
SFRP5 309377  
SFRP5 54612 Q9WU66

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SFRP5 Proteins (SFRP5) by Origin

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More Proteins for SFRP5 Interaction Partners

Zebrafish Secreted Frizzled-Related Protein 5 (SFRP5) interaction partners

  1. note an increase in BMP ligand expression in Sfrp1a/5 depleted embryos, a phenotype similar to that seen in embryos with inhibited BMP signaling

  2. Sfrp5 inhibits both canonical and non-canonical Wnt (show WNT2 Proteins) signaling during embryonic and endodermal development

Xenopus laevis Secreted Frizzled-Related Protein 5 (SFRP5) interaction partners

  1. propose that XsFRP5 exerts an early regulatory function in the specification of the ventral pancreas, as well as a late function in controlling stomach size via inhibition of Wnt (show WNT2 Proteins) signalling

Human Secreted Frizzled-Related Protein 5 (SFRP5) interaction partners

  1. Report reduced hepatic SFRP5 expression in morbidly women with NAFLD.

  2. Data suggest that serum SFRP5 levels are up-regulated in subjects with newly diagnosed type 2 diabetes as compared to prediabetic or control subjects; subjects were matched for obesity/overweight/body mass index.

  3. Serum WISP2 (show WISP2 Proteins) correlated directly with fatty acid binding protein 4. Serum SFRP5 did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (p<5x10(-6) as compared to both PCOS groups).

  4. Sfrp5 represents a candidate for a mature adipocyte marker gene.

  5. The wnt5a (show WNT5A Proteins)/sFRP5 system is altered in human sepsis and might therefore be of interest for future studies on molecular pathophysiology of this common human disease.

  6. Serum SFRP5 is regulated by weight status and seems to be correlated with metabolic disorders in children.

  7. We were able to show a significant association of sFRP5 with both total abdominal and subcutaneous fat. The association signal was only seen in obese males in which the minor allele of rs7072751 explains 1.8 % of variance in total abdominal fat.

  8. Aberrant methylation of APC (show APC Proteins) gene was statistically significant associated with age over 50, DDK3 with male, SFRP4 (show SFRP4 Proteins), WIF1 (show WIF1 Proteins), and WNT5a (show WNT5A Proteins) with increasing tumor stage SFRP4 (show SFRP4 Proteins) and WIF1 (show WIF1 Proteins) with tumor differentiation and SFRP2 (show SFRP2 Proteins) and SFRP5 with histological type

  9. SFRP5 and WNT5A comprise a balanced duo that may regulate metabolic homeostasis in prepubertal children.

  10. Secreted frizzled-related protein 5 suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through down-regulation of c-Jun N-terminal kinase.

Mouse (Murine) Secreted Frizzled-Related Protein 5 (SFRP5) interaction partners

  1. MicroRNA-124 regulates cell specification in the cochlea through modulation of Sfrp4 (show SFRP4 Proteins) and Sfrp5.

  2. although high sFRP5 expression inhibits B-lymphopoiesis in vivo, physiologically, it contributes to the preservation of very primitive lymphopoietic progenitors, including hematopoietic stem cells, under high estrogen levels

  3. A role for SFRP5 in glucose metabolism and pancreatic beta-cell function indicates that the use of an anti-SFRP5 mAb as a potential approach to treat type 2 diabetes.

  4. Sfrp5 mRNA expression and protein secretion depend on the differentiation of adipocytes. The dysregulation of Sfrp5 expression and secretion is directly correlated with insulin (show INS Proteins) resistance.

  5. We propose that Ift88 (show IFT88 Proteins) and primary cilia regulate expression of Sfrp5 and Wnt (show WNT2 Proteins) signaling pathways in growth plate via regulation of Ihh (show IHH Proteins) signaling.

  6. early progeny of Sox2 (show SOX2 Proteins)-positive stem cells transiently expressed the Wnt (show WNT2 Proteins) inhibitor Sfrp5

  7. SFRP5 inhibits WNT (show WNT2 Proteins) signaling to suppress oxidative metabolism and stimulate adipocyte growth during obesity.

  8. data show Sfrp5 is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes; in obesity, Sfrp5 secretion exerts salutary effects on metabolic dysfunction by controlling adipose tissue inflammatory cells

  9. Here we report that the Secreted frizzled-related protein 5 (Sfrp5) gene, which encodes a secreted factor that can antagonize Wnt (show WNT2 Proteins) signaling, is expressed in the AVE and foregut endoderm during early mouse development

  10. Data show that expression of both Sfrp2 (show SFRP2 Proteins) and Sfrp5 during development of the Mullerian duct in male (XY) and female (XX) mouse embryos is dynamic and sexually dimorphic.

SFRP5 Protein Profile

Protein Summary

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.

Alternative names and synonyms associated with SFRP5

  • secreted frizzled-related protein 5 (sfrp5)
  • secreted frizzled-related protein 5 (sfrp5-a)
  • frizzled-related protein 2 (frzb2)
  • secreted frizzled-related protein 5 (SFRP5)
  • secreted frizzled-related protein 5 (Sfrp5)
  • secreted frizzled-related protein 5 (LOC100355147)
  • secreted frizzled-related sequence protein 5 (Sfrp5)
  • AI605071 protein
  • crescent protein
  • D144 protein
  • frp1 protein
  • frp5 protein
  • SARP3 protein
  • sFRP-5 protein
  • sfrp5 protein
  • XsFRP5 protein
  • zgc:101849 protein

Protein level used designations for SFRP5

sfrp1 , secreted frizzled-related sequence protein 5 , sFRP-5 , FRP-1b , SARP-3 , frizzled-related protein 1b , secreted apoptosis related protein 3 , secreted apoptosis-related protein 3 , secreted frizzled-related protein 5

117510 Danio rerio
399205 Xenopus laevis
448129 Xenopus (Silurana) tropicalis
549442 Xenopus (Silurana) tropicalis
282069 Bos taurus
6425 Homo sapiens
309377 Rattus norvegicus
486826 Canis lupus familiaris
423838 Gallus gallus
100716325 Cavia porcellus
100153176 Sus scrofa
100355147 Oryctolagus cuniculus
101109845 Ovis aries
54612 Mus musculus
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