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GRG5/AES (show AES ELISA Kits) interacts with TCF4 (show TCF7L2 ELISA Kits) and represses Wnt (show WNT2 ELISA Kits)-mediated transcription both in human cells and zebrafish embryos.
Data indicte that Tcf-1 (show HNF1A ELISA Kits) and Lef-1 (show LEF1 ELISA Kits) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (show TCF3 ELISA Kits) and -4.
Tcf4 (show TCF7L2 ELISA Kits) transcription factor cooperates in patterning the Xenopus brain.
repeat expansion showed stronger association than the most significantly associated SNP, rs613872, in TCF4, with the disease in the Australian cohort
Although validation in additional patients is required, the findings suggest that the dysmorphic features and severe intellectual disability characteristic of PTHS are partially rescued by overexpression of those short TCF4 transcripts encoding a nuclear localization signal, a transcription activation domain, and the basic helix-loop-helix domain.
these results indicate that targeting components of the PGC1alpha-ID2-TCF4-integrin signaling pathway may suppress melanoma metastasis, and suggest that early use of BRAFV600E inhibitors may have the potential to reduce metastasis.
The variant in TCF7L2 that increases fasting glucose levels increases between-subject variance, whereas variants in GCK and G6PC2 that increase fasting glucose levels decrease between-subject variance.
The rs7903146 (C/T) polymorphism of the TCF7L2 (show TCF7L2 ELISA Kits) gene might not be associated with obesity in the Cameroonian population.
These findings suggest that the rs7903146 locus might exert its enhancer function by interacting with HMGB1 (show HMGB1 ELISA Kits) in an allele dependent manner.
TCF7L2 (show TCF7L2 ELISA Kits) polymorphism is associated with colorectal cancer.
Data show that FERM domain-containing protein 5 (FRMD5) is regulated by both beta-catenin and transcription factor 7-Like 2 protein (TCF7L2) in colon cancer cells.
Altered DNA methylation (show HELLS ELISA Kits) in TCF4 involves in the etiology of Bipolar disorder and Major Depressive disorder .
We found that the genotype "AG" of rs9320010 and "GA" of rs7235757 decreased SCZ risk. In the genetic model analysis, we also observed that the allele "A" of rs9320010 and "G" of rs7235757 were inversely related with the risk of SCZ in the dominant model. Our study indicated that rs9320010, rs7235757, and rs1452787 were prominently associated with SCZ.
along with the elevation of miR-17-5p expression in mouse epididymal fat tissue in response to high fat diet consumption, allowed us to suggest that miR-17-5p is among central switches of adipogenic differentiation
We report that TCF4 comprises two transcriptional isoforms, both of which are required for optimal plasmacytoid DC development in vitro
these data identified E2A (show TCF3 ELISA Kits) and E2-2 as central regulators of B cell immunity.
down-regulation of Id3 (show ID3 ELISA Kits) in B cells is essential for releasing E2A (show TCF3 ELISA Kits) and E2-2, which in a redundant manner are required for antigen-induced B cell differentiation.
TCF7L2 (show TCF7L2 ELISA Kits) mediates canonic Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling and c-Myc (show MYC ELISA Kits) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) to c-Myc (show MYC ELISA Kits) axis can be explored for preventing and treating heart failure.
TCF-4 as a co-activator of p65 (show NFkBP65 ELISA Kits) in the potentiation of proinflammatory cytokine production in macrophages and aggravation of high-fat diet induced chronic inflammation and insulin (show INS ELISA Kits) resistance in mice.
These findings suggest a unique role for Tcf7l2 (show TCF7L2 ELISA Kits) in generating distinct neuronal phenotypes from homogeneous progenitor population.
Tcf7l2 (show TCF7L2 ELISA Kits) may be involved in maintenance of stem/progenitor cells properties.
Data indicate that upregulation of E2-2 protein markedly attenuated the inhibitor of DNA-binding 1 (ID1 (show ID1 ELISA Kits))-mediated increase in endothelial progenitor cells (EPCs) proliferation and migration.
results indicate that miR (show MLXIP ELISA Kits)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) and Wnt (show WNT2 ELISA Kits) signaling pathway by directly targeting Smad7 (show SMAD7 ELISA Kits) and Tcf7l2 (show TCF7L2 ELISA Kits)
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described.
SL3-3 enhancer factor 2
, class B basic helix-loop-helix protein 19
, immunoglobulin transcription factor 2
, Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2)
, class A helix-loop-helix transcription factor ME2
, immunoglobulin transcription factor-2
, R8f DNA-binding protein
, thyroglobulin promoter transcription factor TFE
, transcription factor 7-like 2 (T-cell specific, HMG-box)
, transcriptional factor 4
, helix-loop-helix transcription factor
, LOW QUALITY PROTEIN: transcription factor 4