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along with the elevation of miR-17-5p expression in mouse epididymal fat tissue in response to high fat diet consumption, allowed us to suggest that miR-17-5p is among central switches of adipogenic differentiation
TCF7L2 mediates canonic Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling and c-Myc (show MYC ELISA Kits) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) to c-Myc (show MYC ELISA Kits) axis can be explored for preventing and treating heart failure.
These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.
Tcf7l2 may be involved in maintenance of stem/progenitor cells properties.
results indicate that miR (show MLXIP ELISA Kits)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) and Wnt (show WNT2 ELISA Kits) signaling pathway by directly targeting Smad7 (show SMAD7 ELISA Kits) and Tcf7l2
Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.
Kaiso (show ZBTB33 ELISA Kits) and Sox10 (show SOX10 ELISA Kits) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.
Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination
Tcf7l2 is regulating proinsulin (show INS ELISA Kits) expression directly via Isl1 (show ISL1 ELISA Kits), Ins1 and indirectly via MafA (show MAFA ELISA Kits), NeuroD1 (show NEUROD1 ELISA Kits) and Pdx1 (show PDX1 ELISA Kits).
Transcription factor 7-like 2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway.
Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.
Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.
In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.
Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.
This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (show WNT2 ELISA Kits) signaling in the intestine during zebrafish organogenesis.
XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (show CHRD ELISA Kits) in organizer cells at the gastrula stage
regulation of XTcf-4 by canonical wnt (show WNT2 ELISA Kits)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (show HNF4A ELISA Kits) binding site within its own promoter
The variant in TCF7L2 that increases fasting glucose levels increases between-subject variance, whereas variants in GCK and G6PC2 that increase fasting glucose levels decrease between-subject variance.
The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.
These findings suggest that the rs7903146 locus might exert its enhancer function by interacting with HMGB1 (show HMGB1 ELISA Kits) in an allele dependent manner.
TCF7L2 polymorphism is associated with colorectal cancer.
Data show that FERM domain-containing protein 5 (FRMD5) is regulated by both beta-catenin and transcription factor 7-Like 2 protein (TCF7L2) in colon cancer cells.
the variation of the TCF7L2 gene in three Amerindian populations
These data define the mechanism responsible for the repressive effects of nitric oxide (NO) on the transcriptional activity of beta-catenin (show CTNNB1 ELISA Kits) and link eNOS (show NOS3 ELISA Kits)-derived NO to the modulation by VEGF (show VEGFA ELISA Kits) of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits)-induced endothelial cell proliferation.
we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 (show TCF4 ELISA Kits) and interacts with Wnt (show WNT2 ELISA Kits) response elements (WREs) and promoters of direct target genes of TCF (show HNF4A ELISA Kits) transcription, including: MYC (show MYC ELISA Kits), vimentin (show VIM ELISA Kits), AXIN2 (show AXIN2 ELISA Kits) and LEF1 (show LEF1 ELISA Kits)
novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women
GWAS identified two known loci (TCF7L2 and KCNQ1 (show KCNQ1 ELISA Kits)) reaching genome-wide significance levels in Hispanic type 2 diabetes patients.
findings report an independent confirmation of the association of the TCF7L2 (show TCF4 ELISA Kits) gene with milk yield and composition traits.
Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (show WFS1 ELISA Kits), FTO (show FTO ELISA Kits), SLC30A8 (show SLC30A8 ELISA Kits), and GCKR (show GCKR ELISA Kits), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
transcription factor 7-like 2 (T-cell specific, HMG-box)
, HMG box transcription factor 4
, T-cell factor 4
, T-cell-specific transcription factor 4
, transcription factor 7-like 2
, transcription factor 7-like 2, T-cell specific, HMG-box
, transcription factor tcf4
, T-cell factor XTCF-4A
, transcription factor Tcf4
, T-cell factor-4 variant A
, T-cell factor-4 variant B
, T-cell factor-4 variant C
, T-cell factor-4 variant D
, T-cell factor-4 variant E
, T-cell factor-4 variant F
, T-cell factor-4 variant G
, T-cell factor-4 variant H
, T-cell factor-4 variant I
, T-cell factor-4 variant J
, T-cell factor-4 variant K
, T-cell factor-4 variant L
, T-cell factor-4 variant M
, T-cell factor-4 variant X2