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Western blot analysis demonstrated that following BMP2 (show BMP2 Proteins) and BMP7 (show BMP7 Proteins) cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (show BMP2 Proteins), BMP4 (show BMP4 Proteins), BMP6 (show BMP6 Proteins), BMP7 (show BMP7 Proteins), BMP9 (show GDF2 Proteins) and Wnt3a were increased compared with control cells
Wnt3a promotes macrophage-mediated bacterial killing by elevating CRAMP and BD1 (show DEFB1 Proteins) levels.
Wnt3a acutely reduces nuclear acetyl-CoA (show LPCAT1 Proteins), the necessary substrate for histone acetyltransferases, resulting in a global decrease in histone acetylation.
Wnt3a rapidly activated the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway and pharmacological stimulation of cAMP/PKA signaling suppressed osteoclast differentiation
Mesenchymal Stem Cells Within Gelatin/CaSO4 Scaffolds Treated Ex Vivo with Low Doses of BMP-2 (show BMP2 Proteins) and Wnt3a Increase Bone Regeneration.
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
that activation of the Wnt (show WNT2 Proteins) pathway made cells more readily tolerate ROS (show ROS1 Proteins)-caused mitochondria injury and cell apoptosis
Pin1 (show PIN1 Proteins) is indispensable for Wnt3a-induced osteoblast differentiation.
The mouse xenograft model showed that Wnt3a-overexpressing cells grew into larger tumor masses and formed more vasculogenic mimicry than the control cells.
miR (show MLXIP Proteins)-27-3p inhibits melanogenesis by repressing Wnt3a protein expression.
we performed a rescue experiment in the JB6 cell line and found that the inhibitory effect of Wnt5a on cell proliferation could be rescued by the addition of Wnt3a. Our data reveal that Wnt5a suppresses the activation of b-catenin signaling during hair follicle regeneration.
The level of Wnt3a expression in hepatocellular carcinoma(HCC (show FAM126A Proteins)) patients was obviously higher than that in any group of cases with benign liver diseases. The diagnostic specificity or the area under the receiver operating characteristic curve was 94.34 % or 0.994 in Wnt3a and 69.81 % or 0.710 in AFP (show AFP Proteins) for HCC (show FAM126A Proteins), respectively.
Oncogenic Wnt3a expression associated with HBV infection and cirrhotic liver might be an independent prognostic factor for hepatocellular carcinoma.
AurkA (show AURKA Proteins) suppresses the expression of miR (show MLXIP Proteins)-128, inhibitor of wnt3a mRNA stabilization.
The pool of ADP-ribosylated Axin (show AXIN1 Proteins), which is degraded under basal conditions, increases immediately following Wnt (show WNT2 Proteins) stimulation in both Drosophila and human cells.
The results reveal a novel inhibitory role of Wnt3a on canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and cancer cell proliferation when there is an insufficient blood supply during tumor development.
The interaction between Wnt (show WNT2 Proteins) isoforms and their LRP6 (show LRP6 Proteins) cognate receptor depends on the jutting loop present in Wnt3a but absent in Wnt5b (show WNT5B Proteins).
Upregulated Wnt3a in colon cancer cells promoted the capacity to form tube-like structures in the three-dimensional (3-D) culture together with increased expression of endothelial phenotype-associated proteins such as VEGFR2 (show KDR Proteins) and VE-cadherin (show CDH5 Proteins).
72 Wnt (show WNT2 Proteins) target genes higher expressed in triple-negative breast cancer
a Wnt (show WNT2 Proteins)-amplified environment was associated with superior pulp healing.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.
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