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anti-ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) Antibodies

The membrane-associated protein encoded by ABCG2 is included in the superfamily of ATP-binding cassette (ABC) transporters.

list all antibodies Gene Name GeneID UniProt
Anti-Human ABCG2 ABCG2 9429 Q9UNQ0
Anti-Mouse ABCG2 ABCG2 26357 Q7TMS5
Anti-Rat ABCG2 ABCG2 312382 Q80W57
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More Antibodies against ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 Interaction Partners

Human ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. Here we review the mechanisms that modulate MDR mediated by the ABC transporter ABCG2 in normal and cancer cells by different levels including, epigenetic modifications, transcriptional, post-transcriptional, translation and post-translational regulation

  2. UA could inhibit proliferation and reverse the drug resistance of ovarian CSC by suppressing ABCG2.

  3. Data show that ATP-binding cassette subfamily G member 2 (ABCG2) expression correlates with the presence of CD133 antigen-positive cancer cells, and thus is a possible therapeutic target for colorectal cancer.

  4. analysis of ABCB1 (show ABCB1 Antibodies) C3435T, ABCG2 C421A, and XRCC1 (show XRCC1 Antibodies) Arg194Trp genetic polymorphism associations with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia (show BCL11A Antibodies)

  5. Report novel pyrimido[1'',2'':1,5]pyrazolo[3,4-b]quinolones that reverse ABCG2-mediated resistance in cancer cells.

  6. The A allele of ABCG2 C421A may be a risk factor for progression of breast cancer in Kurdish patients

  7. Report ABCG2 induction by genistein in breast cancer cells may result in drug resistance in tumors treated with substrates of this transport.

  8. Inherently high expression of ABCG2 in endocardial endothelial cells protects them against apoptosis in presence of anticancer agents.

  9. our analysis of the expression of nestin (show NES Antibodies), CD133 and ABCG2 in rhabdomyosarcomas, Ewing sarcomas and osteosarcomas represents the first complex study of these three putative CSCs markers together in three different types of pediatric sarcomas and showed their possible prognostic values in these tumors.

  10. In this work, we analyzed the expression of CD133, FOXP3 (show FOXP3 Antibodies), ABCG2 and CD24 (show CD24 Antibodies) in women affected by vulvar cancer, correlating these with common clinical prognostic factors

Pig (Porcine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. Inherently high expression of ABCG2 in endocardial endothelial cells protects them against apoptosis in presence of anticancer agents.

Cow (Bovine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. These findings point to a significant role of the ABCG2 Y581S polymorphism in the milk disposition of enterolactone and the endogenous molecules riboflavin and uric acid, which could affect both milk quality and functionality.

  2. The results suggest that a mutation of SCD1 (show SCD Antibodies), but not LEPR (show LEPR Antibodies) or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

  3. P-gp (show ABCB4 Antibodies), Bcrp and Mrp1 (show ABCC1 Antibodies) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  4. This study has, for the first time, confirmed the expression of ABCG2 in epithelial cells of the bovine rumen.

  5. These results contribute to the role of ABCG2 in cytoprotection and disposition in important tissue barriers and may have important implications for veterinary pharmacotherapy of dairy animals.

  6. Generated cell culture model allows rapid and high-throughput screening of potential ruminant ABCG2 substrate, increasing the understanding of carrier-associated secretion of xenobiotics into milk.

  7. Bovine ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the veterinary antibiotic danofloxacin.

  8. ABCG2 plays a role in mammary epithelial cell proliferation, and functional polymorphisms in this gene may influence the cellular compartment of the mammary gland and potentially milk production.

  9. The effect of the Y581S polymorphism of ABCG2 on transcellular transport of veterinary drugs was studied because this could alter substrate pharmacokinetics and milk residues.

  10. Data suggest that the BB genotype of bovine ABCG2 is a molecular marker for superior milk performance.

Mouse (Murine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. Report novel pyrimido[1'',2'':1,5]pyrazolo[3,4-b]quinolones that reverse ABCG2-mediated resistance in cancer cells.

  2. Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1 (show SLC2A9 Antibodies), ABCG2, and URAT1 (show SLC22A12 Antibodies). Immunostaining for GLUT9 (show SLC2A9 Antibodies) was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization.

  3. [(18)F]Mefway is modulated by P-gp (show ABCB4 Antibodies), and not by Bcrp in rodents.

  4. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  5. Coadministration of ceritinib with a dual ABCB1 (show ABCB1 Antibodies) and ABCG2 inhibitor may improve treatment of brain (micro) metastases.

  6. Pparalpha (show PPARA Antibodies) complex translocates from the cytoplasm into the nucleus and further recruits coactivators and transcription machinery which induce the transcription of Abcg2 gene and ultimately results in upregulation of Bcrp protein expression and function

  7. Among the ABC (show ABCB6 Antibodies) drug transporters, only ABCG2 was expressed at highly increased levels in a mouse G3 medulloblastoma model.

  8. The studies using Bcrp KO mice serve as an estimation of the clinical plasma concentration-time curve changes in ABCG2 421C>A variants for BCRP substrate drugs with the F ratio correcting the systemic clearance change by Bcrp knockout in Bcrp KO mice.

  9. the renal urate excretion was increased in Abcg2-knockout mice

  10. Data indicate that the brain penetration of ABT-888 in both Abcb1a (show ABCB4 Antibodies)/1b-/- and Abcb1a (show ABCB4 Antibodies)/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.

Rabbit ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. Functional expression of the ABCG2 efflux transporter in rabbit placenta.

  2. ABCG2-dependent dye exclusion undergoes large expansion in explant culture and becomes associated with high colony formation efficiency.

ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) Antigen Profile

Protein Summary

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ABCG2

  • ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2) antibody
  • ATP-binding cassette, sub-family G (WHITE), member 2 (abcg2) antibody
  • ATP-binding cassette, sub-family G (WHITE), member 2 (Abcg2) antibody
  • ATP-binding cassette, subfamily G (WHITE), member 2 (Abcg2) antibody
  • ABC15 antibody
  • ABCG2 antibody
  • ABCG3 antibody
  • ABCP antibody
  • AI428558 antibody
  • BCRP antibody
  • Bcrp1 antibody
  • BMDP antibody
  • CD338 antibody
  • CDw338 antibody
  • EST157481 antibody
  • GOUT1 antibody
  • MRX antibody
  • MXR antibody
  • MXR1 antibody
  • UAQTL1 antibody

Protein level used designations for ABCG2

ATP-binding cassette, sub-family G, member 2 , breast cancer resistance protein , ATP-binding cassette sub-family G member 2 , ATP-binding cassette transporter subfamily G member 2 , ATP-binding cassette, sub-family G (WHITE), member 2 , ATP-binding cassette sub-family G member 2-like , ABC transporter , ATP-binding cassette transporter G2 , mitoxantrone resistance-associated protein , multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 , placenta specific MDR protein , placenta-specific ATP-binding cassette transporter , ATP-binding cassette protein G2 , brain multidrug resistance protein , ATP binding cassette superfamily G number 2 transporter , breast cancer resistance protein 1 homolog , mitoxantrone resistance protein 1 , ATP-binding cassette transporter sub-family G member 2

GENE ID SPECIES
471251 Pan troglodytes
734088 Xenopus (Silurana) tropicalis
780508 Ovis aries
100034164 Equus caballus
100431737 Pongo abelii
9429 Homo sapiens
100036892 Xenopus laevis
423767 Gallus gallus
478472 Canis lupus familiaris
397073 Sus scrofa
536203 Bos taurus
26357 Mus musculus
100008640 Oryctolagus cuniculus
574307 Macaca mulatta
312382 Rattus norvegicus
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