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anti-ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) Antibodies

The membrane-associated protein encoded by ABCG2 is included in the superfamily of ATP-binding cassette (ABC) transporters.

list all antibodies Gene Name GeneID UniProt
Anti-Human ABCG2 ABCG2 9429 Q9UNQ0
Anti-Mouse ABCG2 ABCG2 26357 Q7TMS5
Anti-Rat ABCG2 ABCG2 312382 Q80W57
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More Antibodies against ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 Interaction Partners

Human ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. High expression of ABCG2 in both the cytoplasm and membrane was found more frequently in well-differentiated lesions od colorectal carcinoma.

  2. The different 5' UTR (show UTS2R Antibodies) variants play an important role in cell type specific regulation and fine tuning of ABCG2 expression.

  3. Here, it is our intention to review: 1) recent discoveries that further characterize the role of ABCG2 in oncology, and 2) advances in reversing and circumventing ABC transporter-mediated resistance to anti-cancer therapies.

  4. These results suggested that the ABCG2 polymorphisms might be a candidate pharmacogenomic factor to assess susceptibility and prognosis for breast carcinoma patients.

  5. These results demonstrate that enhanced ABCG2 activity renders TNBC cell resistance to ALA-PDT (show TWIST1 Antibodies) and inhibiting ABCG2 transporter is a promising approach for targeting TNBC with ALA-based modality.

  6. hyperactivity of Hh signaling resulted in EGFR (show EGFR Antibodies)-TKI resistance, by EMT (show ITK Antibodies) introduction and ABCG2 upregulation, and blockade of Hh signaling synergistically increased sensitivity to EGFR (show EGFR Antibodies)-TKIs in primary and secondary resistant NSCLC cells

  7. association of a functional germline variant on ABCG2 that affects the pharmacokinetics of sunitinib with sunitinib-induced toxicity of renal cell carcinoma (show MOK Antibodies) patients in the Japanese population

  8. ABCG2 was associated with an increased risk of gout during middle age for men (HR = 2.60, 95% CI: 1.89-3.57) and women (HR = 1.78, 95% CI: 1.07-2.96).

  9. Our data suggest that Nrf2 (show GABPA Antibodies)-mediated ABCG2 over expression in lung adenocarcinoma SP (side population) cells might responsible for chemotherapy failure

  10. We conclude from our results that the C421A SNP may lead to reduced ABCG2 protein levels not only by affecting cellular protein stability but also via enhanced microRNA-dependent ABCG2 repression.

Cow (Bovine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. The results suggest that a mutation of SCD1 (show SCD Antibodies), but not LEPR (show LEPR Antibodies) or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

  2. P-gp (show ABCB4 Antibodies), Bcrp and Mrp1 (show ABCC1 Antibodies) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  3. This study has, for the first time, confirmed the expression of ABCG2 in epithelial cells of the bovine rumen.

  4. These results contribute to the role of ABCG2 in cytoprotection and disposition in important tissue barriers and may have important implications for veterinary pharmacotherapy of dairy animals.

  5. Generated cell culture model allows rapid and high-throughput screening of potential ruminant ABCG2 substrate, increasing the understanding of carrier-associated secretion of xenobiotics into milk.

  6. Bovine ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the veterinary antibiotic danofloxacin.

  7. ABCG2 plays a role in mammary epithelial cell proliferation, and functional polymorphisms in this gene may influence the cellular compartment of the mammary gland and potentially milk production.

  8. The effect of the Y581S polymorphism of ABCG2 on transcellular transport of veterinary drugs was studied because this could alter substrate pharmacokinetics and milk residues.

  9. Data suggest that the BB genotype of bovine ABCG2 is a molecular marker for superior milk performance.

  10. The recent progress in mapping quantitative trait nucleotides (QTNs) are reviewed, including the ABCG2 gene mutation that underlies a QTL for fat and protein content and the ovine MSTN (show MSTN Antibodies) gene mutation that causes muscular hypertrophy in Texel sheep.

Mouse (Murine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. Coadministration of ceritinib with a dual ABCB1 (show ABCB1 Antibodies) and ABCG2 inhibitor may improve treatment of brain (micro) metastases.

  2. Pparalpha (show PPARA Antibodies) complex translocates from the cytoplasm into the nucleus and further recruits coactivators and transcription machinery which induce the transcription of Abcg2 gene and ultimately results in upregulation of Bcrp protein expression and function

  3. Among the ABC (show ABCB6 Antibodies) drug transporters, only ABCG2 was expressed at highly increased levels in a mouse G3 medulloblastoma model.

  4. The studies using Bcrp KO mice serve as an estimation of the clinical plasma concentration-time curve changes in ABCG2 421C>A variants for BCRP substrate drugs with the F ratio correcting the systemic clearance change by Bcrp knockout in Bcrp KO mice.

  5. the renal urate excretion was increased in Abcg2-knockout mice

  6. Data indicate that the brain penetration of ABT-888 in both Abcb1a (show ABCB4 Antibodies)/1b-/- and Abcb1a (show ABCB4 Antibodies)/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.

  7. Expression profiling of mRNA isoforms revealed that E1b (show BCKDHB Antibodies) is predominantly expressed and induced in the lactating mammary gland. E1b (show BCKDHB Antibodies) promoter sequences in the virgin gland are already hypomethylated and marked with the open chromatin histone mark H3K4me2.

  8. Abcg2 plays a cytoprotective role in response to in vivo oxidative stress.

  9. CYT387 was efficiently transported by both human MDR1 (show ABCB4 Antibodies) and BCRP, and very efficiently by mouse Bcrp1 (show BANF1 Antibodies) and its transport could be inhibited by specific MDR1 (show ABCB4 Antibodies) inhibitor, zosuquidar and/or specific BCRP inhibitor, Ko143.

  10. Inhibitors also demonstrated similar effects on human and mouse ABCG2.

Rabbit ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. ABCG2-dependent dye exclusion undergoes large expansion in explant culture and becomes associated with high colony formation efficiency.

ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) Antigen Profile

Protein Summary

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ABCG2

  • ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2) antibody
  • ATP-binding cassette, sub-family G (WHITE), member 2 (abcg2) antibody
  • ATP-binding cassette, sub-family G (WHITE), member 2 (Abcg2) antibody
  • ATP-binding cassette, subfamily G (WHITE), member 2 (Abcg2) antibody
  • ABC15 antibody
  • ABCG2 antibody
  • ABCG3 antibody
  • ABCP antibody
  • AI428558 antibody
  • BCRP antibody
  • Bcrp1 antibody
  • BMDP antibody
  • CD338 antibody
  • CDw338 antibody
  • EST157481 antibody
  • GOUT1 antibody
  • MRX antibody
  • MXR antibody
  • MXR1 antibody
  • UAQTL1 antibody

Protein level used designations for ABCG2

ATP-binding cassette, sub-family G, member 2 , breast cancer resistance protein , ATP-binding cassette sub-family G member 2 , ATP-binding cassette transporter subfamily G member 2 , ATP-binding cassette, sub-family G (WHITE), member 2 , ATP-binding cassette sub-family G member 2-like , ABC transporter , ATP-binding cassette transporter G2 , mitoxantrone resistance-associated protein , multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 , placenta specific MDR protein , placenta-specific ATP-binding cassette transporter , ATP-binding cassette protein G2 , brain multidrug resistance protein , ATP binding cassette superfamily G number 2 transporter , breast cancer resistance protein 1 homolog , mitoxantrone resistance protein 1 , ATP-binding cassette transporter sub-family G member 2

471251 Pan troglodytes
734088 Xenopus (Silurana) tropicalis
780508 Ovis aries
100034164 Equus caballus
100431737 Pongo abelii
9429 Homo sapiens
100036892 Xenopus laevis
423767 Gallus gallus
478472 Canis lupus familiaris
397073 Sus scrofa
536203 Bos taurus
26357 Mus musculus
100008640 Oryctolagus cuniculus
574307 Macaca mulatta
312382 Rattus norvegicus
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