ABCG2 antibody (AA 305-335)

Catalog No. ABIN3030062

Product Details anti-ABCG2 Antibody

Target: ABCG2 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2))

Binding Specificity: AA 305-335

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCG2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Purification: Purified

Immunogen: A portion of amino acids 305-335 from the human protein was used as the immunogen for this ABCG2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the ABCG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ABCG2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for ABCG2

Target: ABCG2 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2))

Alternative Name: ABCG2 (ABCG2 Products)

Synonyms: bcrp antibody, ABCG2 antibody, ABC15 antibody, ABCP antibody, BCRP antibody, BCRP1 antibody, BMDP antibody, CD338 antibody, CDw338 antibody, EST157481 antibody, GOUT1 antibody, MRX antibody, MXR antibody, MXR1 antibody, UAQTL1 antibody, AI428558 antibody, Bcrp1 antibody, ABCG3 antibody, ATP binding cassette subfamily G member 2 antibody, ATP binding cassette subfamily G member 2 (Junior blood group) antibody, ATP binding cassette subfamily G member 2 (Junior blood group) L homeolog antibody, ATP-binding cassette, sub-family G (WHITE), member 2 antibody, ATP-binding cassette sub-family G member 2 antibody, ABCG2 antibody, abcg2 antibody, abcg2.L antibody, Abcg2 antibody, LOC100008640 antibody

Background: ABCG2 is a membrane-associated protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.

UniProt: Q9UNQ0

Pathways: Transition Metal Ion Homeostasis