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Actinin, alpha 3 Proteins (ACTN3)

ACTN3 encodes a member of the alpha-actin binding protein gene family. Additionally we are shipping ACTN3 Antibodies (53) and ACTN3 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACTN3 11474 O88990
Rat ACTN3 ACTN3 171009  
ACTN3 89 Q08043
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Top ACTN3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$704.00
Details

ACTN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human
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More Proteins for Actinin, alpha 3 (ACTN3) Interaction Partners

Horse (Equine) Actinin, alpha 3 (ACTN3) interaction partners

  1. The ACTN3 gene is 13.2 kb long and contains 21 exons. The equine ACTN3 gene has a ubiquitous expression but it is overexpressed in skeletal muscles

Mouse (Murine) Actinin, alpha 3 (ACTN3) interaction partners

  1. New insights that have been made in understanding the molecular mechanisms that underlie the consequences of alpha-actinin-3 deficiency.[review]

  2. Absence of alpha-actinin-3 resulted in reduced atrophic response and altered adaptation to disuse, as measured by a change in myosin heavy chain isoform.

  3. ACTN3 likely contributes to the regulation of bone mass through alterations in bone turnover.

  4. Data demonstrated that the Z-disk proteins, ZASP (show LDB3 Proteins), titin (show TTN Proteins) and vinculin (show VCL Proteins) preferentially bind to alpha-actinin-2 (show ACTN2 Proteins). Thus, the loss of alpha-actinin-3 changes the overall protein composition of fast fiber Z-disks and alters their elastic properties.

  5. Actn3 knockout mice showed differences in intrinsic exercise performance, fast muscle force generation and male muscle mass.

  6. alpha-actinin-3 may play a role in the development of fast-twitch, glycolytic properties in a muscle fiber, and in its absence slower twitch, more oxidative properties may develop.

  7. alpha-Actinin-3 deficiency reduces the activity of glycogen (show GYS1 Proteins) phosphorylase and results in a fundamental shift toward more oxidative pathways of energy utilization--REVIEW

  8. alpha-actinin-3 expression in a knockout mouse model results in a shift in muscle metabolism toward the more efficient aerobic pathway and an increase in intrinsic endurance performance

  9. Study reports that muscle from Actn3 knockout mice displays reduced force generation, consistent with results from human association studies.

  10. the shift towards more efficient aerobic muscle metabolism associated with alpha-actinin-3 deficiency also underlies the adaptive benefit of the 577X allele

Human Actinin, alpha 3 (ACTN3) interaction partners

  1. ACTN3 and ACE (show ACE Proteins) genotypes influence sprint time in elite male athletes; No genotype differences were detected in sprint performance in both Caucasian and African ancestry sprinters

  2. These results suggest that the ACTN3 gene may play a significant role in determining muscle phenotypes. However, this gene is only one of many factors which could contribute to athletes' performance and muscle phenotypes.

  3. The present study provides novel findings associating the ACTN3 R577X polymorphism with physiological variables that are connected to endurance performance.

  4. Our results suggest that the ACTN3 R577X genotype is associated with lower-extremity muscle function in the Japanese population.

  5. New insights that have been made in understanding the molecular mechanisms that underlie the consequences of alpha-actinin-3 deficiency.

  6. F-actin and cell-matrix adhesions differently affect membrane dynamics and cell migration.

  7. The ACTN3 R577X is associated with acute ankle sprains in this study.

  8. This study aimed at determining the influence of the ACTN3 R577X polymorphism on muscle strength and muscle endurance in non-athletic young men

  9. Authors present a simple and cost-efficient method to genotype the ACTN3 r577x polymorphism by a single PCR.

  10. The ACTN3 R577X polymorphism is associated with cardiometabolic fitness in healthy young adults.

Rabbit Actinin, alpha 3 (ACTN3) interaction partners

  1. examine the dynamics of actin in the presence of alpha-acinin in solution; suggest mechanisms to deny binding access to other actin-binding proteins and may explain how very different actin cytoskeletal structures may co-exist in the same cell

  2. Alpha-actinin may contribute to tension sensing in actin bundles.

ACTN3 Protein Profile

Protein Summary

This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants. The reference genome contains the non-coding allele. The non-functional allele of this gene is associated with elite athlete status.

Gene names and symbols associated with Actinin, alpha 3 Proteins (ACTN3)

  • alpha actinin 3 (Actn3)
  • actinin, alpha 3 (actn3)
  • actinin, alpha 3 (ACTN3)
  • actinin alpha 3 (Actn3)
  • actinin, alpha 3 (Actn3)
  • acta-3 protein
  • CG8953 protein
  • dabp protein
  • Dmel\\CG8953 protein
  • ORF1 protein

Protein level used designations for Actinin, alpha 3 Proteins (ACTN3)

Actn3-PA , CG8953-PA , alpha-actinin-like , alpha-actinin3 , open reading frame 1 , actinin, alpha 3 , alpha-actinin-3 , alpha 3 actinin , alpha-actinin-3-like , F-actin cross-linking protein , alpha-actinin skeletal muscle , muscle alpha-actinin subunit

GENE ID SPECIES
44964 Drosophila melanogaster
446326 Xenopus laevis
713811 Macaca mulatta
100033871 Equus caballus
100216053 Xenopus (Silurana) tropicalis
100439754 Pongo abelii
11474 Mus musculus
171009 Rattus norvegicus
89 Homo sapiens
100009544 Oryctolagus cuniculus
100730348 Cavia porcellus
539375 Bos taurus
483707 Canis lupus familiaris
101115917 Ovis aries
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