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Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Additionally we are shipping ACER3 Antibodies (30) and and many more products for this protein.
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The ACER3 deficiency resulted in decreased cell growth and colony formation, elevated apoptosis, and lower AKT (show AKT1 ELISA Kits) signaling of leukemia cells. This study indicates that ACER3 contributes to AML (show RUNX1 ELISA Kits) pathogenesis, and suggests that alkaline ceramidase inhibition is an option to treat acute myeloid leukemia (show BCL11A ELISA Kits).
ACER3 catalyzes the hydrolysis of unsaturated long chain ceramides and dihydroceramides and coordinates with ACER2 (show ACER2 ELISA Kits) to regulate cell proliferation and survival
Alkaline ceramidase 3 expression has an important role in the innate immune response by regulating the expression of pro-inflammatory cytokines in cells of the innate immune system through C18:1-ceramide.
Acer3 plays critically protective roles in controlling the homeostasis of various sphingolipids, including ceramides, sphingosine, S1P (show S1PR1 ELISA Kits), and certain complex sphingolipids in the brain and protects Purkinje cells from premature degeneration.
Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity (By similarity).
, alkCDase 3
, alkaline CDase 3
, alkaline dihydroceramidase SB89
, alkaline phytoceramidase