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Alkaline Phosphatase, Intestinal Proteins (ALPI)

ALPI encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Additionally we are shipping Intestinal Alkaline Phosphatase Antibodies (260) and Intestinal Alkaline Phosphatase Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALPI 11648  
ALPI 248 P09923
ALPI 24197  
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Top Intestinal Alkaline Phosphatase Proteins at

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Human Cells Human Fc Tag 50 μg Log in to see 16 Days
HOST_Mammalian Cells Mouse Fc Tag   50 μg Log in to see 5 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

ALPI Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , , , ,
, ,
Rat (Rattus)

More Proteins for Alkaline Phosphatase, Intestinal (ALPI) Interaction Partners

Mouse (Murine) Alkaline Phosphatase, Intestinal (ALPI) interaction partners

  1. Authors found that Akp3(-/-) mice acquired lipopolysaccharide tolerance during postweaning development, suggesting that Akp3 plays an important role in immune education.

  2. Intestinal alkaline phosphatase prevents metabolic syndrome in mice.

  3. It is concluded that CD36 (show CD36 Proteins) exists in its phosphorylated and dephosphorylated states in mouse enterocytes and that pCD36 is a substrate of global intestinal alkaline phosphatase (gIAP).

  4. These data suggest that IAP is a local immunomodulating factor, perhaps regulating LPS-toll-like receptor 4 (show TLR4 Proteins) (TLR4 (show TLR4 Proteins)) interaction between commensal microflora and intestinal epithelium.

  5. Results suggest that intestinal alkaline phosphatase participates in a rate-limiting step regulating fat absorption.

  6. forced high-fat chow induced an 18% greater body weight gain, hepatic steatosis, and visceral fat accumulation in female Akp3(-/-) mice but not in female wild-type controls. there is 2X increase of lipid absorption in Akp3(-/-) male mice.

  7. Intestinal alkaline phosphatase activity may have a role in mediating the accelerated fatty acid intake observed in Akp3 knockout mice fed a high-fat diet.

  8. Suggest role for lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.

Human Alkaline Phosphatase, Intestinal (ALPI) interaction partners

  1. The results suggested a critical role of CD47 (show CD47 Proteins) in laryngeal squamous cell carcinoma development.

  2. Data show that anti-human CD47 (show CD47 Proteins) antibody B6H12 decreased expression of epidermal growth factor receptor (EGFR (show EGFR Proteins)) and the stem cell transcription factors.

  3. suggest that microglial activation may be partially caused by CD47 (show CD47 Proteins)/signal regulatory protein-alpha (show SIRPA Proteins)- and CD200 (show CD200 Proteins)/CD200R (show CD200R1 Proteins)-mediated reductions in the immune inhibitory pathways

  4. Our results highlight an underappreciated contribution of the adaptive immune system to anti-CD47 (show CD47 Proteins) adjuvant therapy and suggest that targeting both innate and adaptive immune checkpoints can potentiate the vaccinal effect of antitumor antibody therapy.

  5. A High Level of Intestinal Alkaline Phosphatase Is Protective Against Type 2 Diabetes Mellitus Irrespective of Obesity

  6. Data suggest a reduction in the CD47 antigen (show CD47 Proteins)/signal-regulatory protein alpha (show SIRPA Proteins) (SIRPalpha) pathway by programmed cell death protein 1 (PD-1 (show PDCD1 Proteins)) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).

  7. Review of the role of intestinal alkaline phosphatase in inflammatory diseases. Loss of IAP expression or function is associated with increased intestinal inflammation, dysbiosis, bacterial translocation and subsequently systemic inflammation.

  8. atherogenesis is associated with upregulation of CD47 (show CD47 Proteins), a key anti-phagocytic molecule that is known to render malignant cells resistant to programmed cell removal, or 'efferocytosis'

  9. CD47 (show CD47 Proteins) is a critical regulator in the metastasis of osteosarcoma and results suggest that targeted inhibition of this antigen by anti-CD47 (show CD47 Proteins) may be a novel immunotherapeutic approach in the management of this tumor.

  10. agents that block the CD47 (show CD47 Proteins):SIRP (show SIRPA Proteins)-alpha engagement are attractive therapeutic targets as a monotherapy or in combination with additional immune-modulating agents for activating antitumor T cells in vivo

Cow (Bovine) Alkaline Phosphatase, Intestinal (ALPI) interaction partners

  1. Mechanism of IAP action appears to be through dephosphorylation of specific bacterial components, including LPS (show IRF6 Proteins), CpG DNA, and flagellin (show FliC Proteins), and not on live bacteria. IAP likely targets these bacterially derived molecules as gut (show GUSB Proteins) mucosal defense factor.

  2. Secondary structure of CIP after reaction with Co2+ in different conditions.

Intestinal Alkaline Phosphatase (ALPI) Protein Profile

Protein Summary

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with ALPI

  • alkaline phosphatase, intestinal, tandem duplicate 1 (alpi.1)
  • alkaline phosphatase, intestinal (ALPI)
  • alkaline phosphatase, placental (ALPP)
  • alkaline phosphatase, placental-like 2 (ALPPL2)
  • alkaline phosphatase 3, intestine, not Mn requiring (Akp3)
  • alkaline phosphatase, intestinal (Alpi)
  • CD47 molecule (CD47)
  • 2010001C14Rik protein
  • Akp-3 protein
  • Akp6 protein
  • Alp1 protein
  • ALPI protein
  • dIAP protein
  • gIAP protein
  • IAP protein
  • im:7149588 protein
  • MER6 protein
  • OA3 protein
  • S51097 protein
  • si:ch211-262h13.1 protein
  • wu:fa95f04 protein
  • zgc:110794 protein

Protein level used designations for ALPI

alkaline phosphatase, intestinal.1 , iap , intestinal alkaline phosphatase 1 , intestinal-type alkaline phosphatase , alkaline phosphatase, intestinal , intestinal-type alkaline phosphatase-like , intestinal alkaline phosphatase , Kasahara isozyme , alkaline phosphomonoesterase , glycerophosphatase , intestinal alkaline phosphatase V , alkaline phosphatase 6 , Alkaline phosphatase 1, intestinal, defined by SSR , IAP-1 , IAP-I , intestinal alkaline phosphatase I IAP-I , intestinal-type alkaline phosphatase 1 , CD47 antigen (Rh-related antigen, integrin-associated signal transducer) , CD47 glycoprotein , Rh-related antigen , antigen identified by monoclonal antibody 1D8 , antigenic surface determinant protein OA3 , integrin associated protein , integrin-associated protein , integrin-associated signal transducer , leukocyte surface antigen CD47

541539 Danio rerio
100399082 Callithrix jacchus
100437471 Pongo abelii
100465399 Ailuropoda melanoleuca
403736 Canis lupus familiaris
740585 Pan troglodytes
11648 Mus musculus
248 Homo sapiens
280993 Bos taurus
76768 Mus musculus
24197 Rattus norvegicus
424936 Gallus gallus
961 Homo sapiens
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