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Acts as a calcium-activated chloride channel (CaCC), mostly in photoreceptors. Additionally we are shipping Anoctamin 2 Antibodies (21) and many more products for this protein.
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residues facing the putative channel pore are responsible both for controlling the ion selectivity and the gating of the channel, providing an initial understanding of molecular mechanism of ion permeation in TMEM16B
data revealed prominently increased autoantibody reactivity against the chloride-channel protein (show CLCA1 Proteins) anoctamin 2 (ANO2) in multiple sclerosis cases compared with controls
Olfactory function impairment in Italian patients with type 3 von Willebrand disease with partial deletion of TMEM16B.
results reveal multidimensional regulation of TMEM16A (show ANO1 Proteins)/16B by preassociated apoCaM and introduce ChIMP (show RCHY1 Proteins) as a versatile tool to probe the macromolecular complex and function of Ca(2 (show CA2 Proteins)+)-activated chloride channels
ANO2 is present in human myometrium.
The third intracellular loop of TMEM16B is the site involved in calcium ion sensitivity, whereas the C-terminal part affects the rate of transition between the open and the closed state of the channel.
VWF (show VWF Proteins) and TMEM16B deletions may have a role in severe von Willebrand disease type 3
This study suggested that TMEM16B to be a strong candidate for the long sought-after Ca(2+)-dependent chloride channel in the photoreceptor synapse.
Ano2 likely amplifies the odor-induced generator potential in olfactory sensory neuron cilia by sensing elevated calcium levels, permitting the outward flow of chloride ions from the cell.
C12orf3, FLJ10261 (ORAOV2 (show ANO1 Proteins)), C11orf25 (show ANO3 Proteins) and FLJ34272 constitute a family of eight-transmembrane proteins with N- and C-terminal tails facing the cytoplasm.
TMEM16B controls AP firing and ensures correct glomerular targeting of olfactory sensory neurons s expressing I7.
Loss of TMEM16B expression resulted in the absence of Calcium-activated Chloride channels in inferior Olive neurons, leading to markedly diminished action potential firing of IO neurons. TMEM16B knockout mice. Moreover, exhibited severe cerebellar motor learning deficits.
The siRNA knock-down suggests that Ano2 contributes to Ca(2 (show CA2 Proteins)+)-dependent chloride conductance in the RPE (show RPE Proteins).
Data indicate that anoctamin channel proteins ANO1 (show ANO1 Proteins) and ANO2 are expressed in the cerebellum.
Ano6 (show ANO6 Proteins) and Ano2 proteins co-localize in the ciliary membrane microdomains.Thus, we provide evidence for interaction of ANO2 and ANO6 (show ANO6 Proteins) in olfactory cilia.
Selective antagonism of ANO2 promotes relaxation of spontaneous myometrial contractions. It inhibits both agonist-induced and spontaneous transient inward currents and abolishes G-protein coupled receptor (show GPR34 Proteins) mediated elevations in intracellular calcium.
Data suggest different functional roles for TMEM16A (show ANO1 Proteins) and TMEM16B in the developing as well as in the postnatal olfactory epithelium
Our results provide the first evidence that TMEM16B gating is modulated by permeant anions and provide the basis for future studies aimed at identifying the molecular determinants of TMEM16B ion selectivity and gating.
The putative pore-loop of TMEM16A (show ANO1 Proteins) and TMEM16B channels affects channel density in cell membranes.
the main functional features of ANO 1 (show ANO1 Proteins) and ANO 2 chloride channels in the nose and suggest their significance for nasal physiology.
Acts as a calcium-activated chloride channel (CaCC), mostly in photoreceptors. May mediate olfactory amplification in olfactory sensory neurons (OSNs) and light perception amplification in retina (By similarity).
, transmembrane protein 16B (eight membrane-spanning domains)
, anoctamin 2 isoform Adelta4
, anoctamin 2 isoform Bdelta4
, transmembrane protein 16B
, anoctamin 2
, anoctamin 2, calcium activated chloride channel