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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Additionally we are shipping APOE Antibodies (320) and APOE Proteins (41) and many more products for this protein.
Showing 10 out of 104 products:
Human APOE ELISA Kit for Sandwich ELISA - ABIN417091
Wu, Liu, Lei, Zhang: Comment on: Cerebrospinal fluid apolipoprotein E concentration decreases after seizure. in Seizure : the journal of the British Epilepsy Association 2010
Show all 6 references for ABIN417091
Mouse (Murine) APOE ELISA Kit for Sandwich ELISA - ABIN415472
Escolà-Gil, Chen, Julve, Quesada, Santos, Metso, Tous, Jauhiainen, Blanco-Vaca: Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. in Biochimica et biophysica acta 2013
Show all 2 references for ABIN415472
study demonstrated ApoE4-containing astrocyte-conditioned media increases mitochondria-associated endoplasmic reticulum membranes (MAM (show ATF7IP ELISA Kits)) function relative to ApoE3; data are consistent with a role of upregulated MAM (show ATF7IP ELISA Kits) function in the pathogenesis of Alzheimer disease and may help explain the contribution of ApoE4 as a risk factor in the disease
Neurometabolic roles of ApoE and Ldl-R in mouse brain.
Suggest Idol (show MYLIP ELISA Kits) as a gatekeeper of LDLR (show LDLR ELISA Kits)-dependent ApoE and Abeta (show APP ELISA Kits) clearance in the brain and a potential enzyme target for therapeutic intervention in Alzheimer disease.
Systemic administration of irisin (show FNDC5 ELISA Kits) may be protected against endothelial injury and ameliorated atherosclerosis in apoE(-/-) diabetic mice.
NPY (show NPY ELISA Kits) might be involved in the pathogenesis of METH (show MTRR ELISA Kits)-induced atherogenic effects through NPY (show NPY ELISA Kits) Y1 receptor pathway in ApoE knockout mice
Plasmalogen enrichment via batyl alcohol supplementation attenuated atherosclerosis in ApoE- and ApoE/GPx1 (show GPX1 ELISA Kits)-deficient mice.
Cx37 (show GJA4 ELISA Kits) deletion increased the size of atherosclerotic lesions in oscillatory shear stress regions and abrogated the development of a stable plaque phenotype under OSS in ApoE(-/-) mice
When chronic allergic lung inflammation (ALI)and atherosclerosis were produced simultaneously, ALI increased atherosclerotic lesion size, inflammatory cell content, elastin (show ELN ELISA Kits) fragmentation, smooth muscle cell loss, lesion cell proliferation, and apoptosis.
ApoE(-/-) mice receiving WD showed abnormal glucose tolerance, hepatomegaly, weight gain and full spectrum of NASH (show SAMSN1 ELISA Kits) including hepatic steatosis, fibrosis and inflammation, with no sign of renal damage
Long-lasting exposure to ox-LDL decreases the expression of Sirt1 (show SIRT1 ELISA Kits) and Runx2 (show RUNX2 ELISA Kits) in bone mesenchymal stem cells which may explain the decreased bone formation in aged apoE(-/-) mice.
ApoE mutations may have a role in increasing the development of diabetic nephropathy among the Egyptian individuals.
The data suggest that the APOE-epsilon4 allele is protective against attention deficit and especially against poor working memory in Hepatitis C virus-infected subjects with mild liver disease.
We demonstrated the benefits of a questionnaire-based approach for assessment of lifestyle risk factors to facilitate clinical interpretation of APOE genotyping genetic subgroup of dyslipidemic patients
The possession of the APOE epsilon4 allele has a small, nonsignificant effect on the presence of delirium. It seems that there is no association between APOE and the occurrence of delirium.[review; meta-analysis]
The results of this study shows that the frequency of epsilon4 allele of ApoE is significantly lower among hypertensive patients on hemodialysis with the highest levels of Asymmetric dimethylarginine .
In older surgery patients free of dementia, the findings do not support the hypothesis that the ApoE genotype does not confer either risk or protection in postoperative delirium incidence, severity, or duration.
ApoE gene polymorphisms associate with CVD and affect the lipid profile. The epsilon4 allele is an independent risk factor for both T2DM and CVD.
Study did not find any differences in the frequencies of ApoE alleles or genotypes between febrile seizures and typically developing individuals
Results suggest that APOE4 is associated with hypertriglyceridaemia, with a slightly increased risk for MetS, but APOE2 is associated with protection against MetS in Uyghur males in China
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (show APOA1 ELISA Kits) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 ELISA Kits) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB ELISA Kits), ApoE, MTP (show MTTP ELISA Kits), and LDLR (show LDLR ELISA Kits), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 ELISA Kits) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (show APOB ELISA Kits)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP ELISA Kits)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3