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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Additionally we are shipping APOE Antibodies (321) and APOE Proteins (41) and many more products for this protein.
Showing 10 out of 104 products:
Human APOE ELISA Kit for Sandwich ELISA - ABIN417091
Wu, Liu, Lei, Zhang: Comment on: Cerebrospinal fluid apolipoprotein E concentration decreases after seizure. in Seizure : the journal of the British Epilepsy Association 2010
Show all 6 references for ABIN417091
Mouse (Murine) APOE ELISA Kit for Sandwich ELISA - ABIN415472
Escolà-Gil, Chen, Julve, Quesada, Santos, Metso, Tous, Jauhiainen, Blanco-Vaca: Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. in Biochimica et biophysica acta 2013
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ApoE(-/-) mice receiving WD showed abnormal glucose tolerance, hepatomegaly, weight gain and full spectrum of NASH (show SAMSN1 ELISA Kits) including hepatic steatosis, fibrosis and inflammation, with no sign of renal damage
Long-lasting exposure to ox-LDL decreases the expression of Sirt1 (show SIRT1 ELISA Kits) and Runx2 (show RUNX2 ELISA Kits) in bone mesenchymal stem cells which may explain the decreased bone formation in aged apoE(-/-) mice.
Report acceleration of atherogenesis in ApoE-/- mice exposed to acute or low-dose-rate ionizing radiation.
Fondaparinux, the selective FXa (show F10 ELISA Kits) inhibitor, can promote the stability of atherosclerotic lesions in apolipoprotein E-deficient mice.
The literatures were searched extensively and this review was performed to review the signaling pathway factors expression in renal tissue of apoE-knockout mice. [review]
Murine norovirus 4 has the potential to exert a variable and unpredictable effect on atherosclerosis in ApoE(-/-) mice.
apoE exerts moderate sex-specific effects on experimental autoimmune encephalomyelitis severity
the effect of T-bet deletion in apolipoproteinE (ApoE) knockout mice fed a high fat diet (HFD) or normal chow diet, was studied.
The use of dietary interventions to slow the progression Alzheimer's disease should take ApoE genotype into consideration.
FXI (show F11 ELISA Kits) deprivation was shown to slow down atherogenesis in Apoe knockout mice.
elevated brain iron adversely impacts Alzheimer's Disease (AD) progression, brain iron elevation is a possible mechanism for APOE-epsilon4 being the major genetic risk factor for AD
Apolipoprotein E allele e2 and genotype e2/e3 were risk factors for type 2 diabetic nephropathy (T2DN) and allele e3 and genotype e3/e3 played a protective role in T2DN
The apolipoprotein E genotype is a powerful risk factor for late-onset Alzheimer's disease.
APOE epsilon4, but not epsilon2, is associated with capillary amyloid angiopathy.
ApoE is located in the nucleus and on the ApoD (show APOD ELISA Kits) promoter in human hepatic and glioblastoma cells lines.
Serum apoE is associated with long-term risk of Alzheimer's disease in the general population, independent of APOE genotype.
elderly community dwelling residents of Han ethnicity carrying the APOE epsilon3/epsilon3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.
Neither total ApoE and ApoE4 levels nor the ApoE/ApoE4 ratio correlated with the diagnosis of Alzheimer's disease.
Results showed that women who possessed any APOE epsilon4 allele experienced a steeper decline in BMI in late life, after age 70 years, irrespective of dementia status
This study demonstrated that APOE and BDNF (show BDNF ELISA Kits) polymorphisms moderate amyloid beta-related cognitive decline in preclinical Alzheimer's disease.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (show APOA1 ELISA Kits) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 ELISA Kits) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB ELISA Kits), ApoE, MTP (show MTTP ELISA Kits), and LDLR (show LDLR ELISA Kits), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 ELISA Kits) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (show APOB ELISA Kits)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP ELISA Kits)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3