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APOE Products

(Apolipoprotein E (APOE))

Categories

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].

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Featured APOE Categories

APOE Antibodies

High quality antibodies with extensive validation data.

APOE ELISA Kits

Reliable ELISA kits for a wide range of species.

APOE Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended APOE Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (9)
Cat. No. ABIN7429133
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (9)
Cat. No. ABIN7429139
Quantity 100 μL
Datasheet Datasheet
Reactivity Dog
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7440422
Quantity 100 μL
Datasheet Datasheet

Recommended APOE ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
  • (1)
Cat. No. ABIN612665
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (8)
  • (1)
Cat. No. ABIN6953857
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6975758
Quantity 96 tests
Datasheet Datasheet

Recommended APOE Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7273868
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7273871
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7273869
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our APOE products

Lindner, Beckenbauer, van Ek, Titeca, de Leeuw, Awwad, Hanke, Korepanova, Rybin, van der Kam, Mohler, Tackenberg, Lakics, Gavin: "Isoform- and cell-state-specific lipidation of ApoE in astrocytes." in: Cell reports, Vol. 38, Issue 9, pp. 110435, (2022) (PubMed).

Zhang, Zong, Jiang, Hu, Cheng, Ni, Yi, Jiang, Tian, Chang, Su, Zhu, Li, Xiang, Miao, Gorospe, de Cabo, Dou, Ju, Yang, Jiang, Yang, Wang: "Hepatic HuR modulates lipid homeostasis in response to high-fat diet." in: Nature communications, Vol. 11, Issue 1, pp. 3067, (2020) (PubMed).

Gordon, Yao, Xu, Karkowsky, Kaler, Kalchiem-Dekel, Barochia, Gao, Keeran, Jeffries, Levine: "Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects." in: The Journal of allergy and clinical immunology, Vol. 144, Issue 2, pp. 426-441.e3, (2020) (PubMed).

Schmid, Prehn, Nimsanor, Garcia, Poulsen, Jørring, Rasmussen, Clausen, Mau-Holzmann, Ramakrishna, Muddashetty, Steeg, Bruce, Mackintosh, Ebneth, Holst, Cabrera-Socorro: "Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line." in: Stem cell research, Vol. 34, pp. 101349, (2019) (PubMed).

Zhao, Liu, Van Ingelgom, Linares, Kurti, Knight, Heckman, Diehl, Shinohara, Martens, Attrebi, Petrucelli, Fryer, Wszolek, Graff-Radford, Caselli, Sanchez-Contreras, Rademakers, Murray, Koga, Dickson et al.: "APOE ε2 is associated with increased tau pathology in primary tauopathy. ..." in: Nature communications, Vol. 9, Issue 1, pp. 4388, (2019) (PubMed).

Lu, Yuan, Wang, Zhang, Yuan, Wu, Zhou, He, Lu, Chen, Fan, Liang, Cheng: "Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7." in: EBioMedicine, Vol. 36, pp. 29-38, (2019) (PubMed).

Zimmerman, Bentley, Lever, Li, Crossman, Song, Liu, Crowley, George, Mrug, Yoder: "Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species." in: Journal of the American Society of Nephrology : JASN, Vol. 30, Issue 5, pp. 767-781, (2019) (PubMed).

Centa, Prokopec, Garimella, Habir, Hofste, Stark, Dahdah, Tibbitt, Polyzos, Gisterå, Johansson, Maeda, Hansson, Ketelhuth, Coquet, Binder, Karlsson, Malin: "Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 38, Issue 8, pp. e145-e158, (2019) (PubMed).

Gupta, Pokhriyal, Das, Khan, Ratna Kumar, Gupta, Chadda, Ramachandran, Goyal, Tripathi, Hariprasad et al.: "Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in cerebrospinal fluid to monitor pharmacotherapeutic efficacy in dopamine dictated disease states of Parkinson's disease and ..." in: Neuropsychiatric disease and treatment, Vol. 15, pp. 2073-2085, (2019) (PubMed).

Chernukha, Fedulova, Kotenkova, Takeda, Sakata: "Hypolipidemic and anti-inflammatory effects of aorta and heart tissues of cattle and pigs in the atherosclerosis rat model." in: Animal science journal = Nihon chikusan Gakkaihō, Vol. 89, Issue 5, pp. 784-793, (2018) (PubMed).

Synonyms and alternative names related to APOE

apolipoprotein E (apoe), apolipoprotein Ea (apoea), apolipoprotein E (Apoe), apolipoprotein E (APOE), ad2, AD2, AI255918, Apo-E, apoe, APOEA, apoprotein, im:7036787, LDLCQ5, LPG, wu:fb69a05, zgc:110064

Protein level used designations for APOE

  • apolipoprotein E
  • ApoE-1
  • apo-E
  • apolipoprotein E3
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