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Arachidonate 5-Lipoxygenase-Activating Protein Proteins (ALOX5AP)

ALOX5AP encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Additionally we are shipping ALOX5AP Antibodies (64) and ALOX5AP Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALOX5AP 11690 P30355
Rat ALOX5AP ALOX5AP 29624 P20291
ALOX5AP 241 P20292
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Top ALOX5AP Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

ALOX5AP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,

More Proteins for Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Interaction Partners

Mouse (Murine) Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) interaction partners

  1. BRP (show GDF5 Proteins)-7 potently suppresses leukotriene biosynthesis by interacting with FLAP in mouse peritonitis model.

  2. FLAP regulates phosphorylation of tau protein via modulating GSK-3beta activity.

  3. This study demonistrated that a a novel role for FLAP in the pathogenesis of anxiety-like behavior in mice.

  4. Deletion of myeloid cell FLAP markedly attenuates the proliferative response to vascular injury, while preserving endothelial integrity.

  5. A FLAP inhibitor given during critical window periods may prevent oxygen induced aberration of pulmonary alveolarization in a dose- and time-dependent manner.

  6. the 5-LO (show ALOX5 Proteins) pathway emerges early during embryonic stem cell differentiation into cells of the myeloid lineage

  7. Adipose tissue from obese mice, compared with that from lean mice, exhibited increased 5-LO (show ALOX5 Proteins) activating protein

  8. Data show that 5-lipoxygenase (show ALOX5 Proteins) activity increases during senescence-like growth arrest via a p53 (show TP53 Proteins)/p21-dependent pathway in both human and mouse embryo fibroblasts.

  9. Altered 5-lipoxygenase (show ALOX5 Proteins) is associated with obesity and bone traits

  10. This observation supports the hypothesis that 5-LO (show ALOX5 Proteins) may be involved in diseases of the brain associated with aging.

Human Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) interaction partners

  1. Genetic interaction of CD80 (show CD80 Proteins) and ALOX5AP was observed in systemic lupus erythematosus in Asian populations.

  2. findings show that several enzymes known to be involved in the biosynthesis of proinflammatory LTs, such as FLAP and cPLA2alpha (show PLA2G4A Proteins), also contribute to LX and Rv formation

  3. The results of this study supported the association of the epistatic interactions of ALOX5AP, THBD (show THBD Proteins), and KNG1 (show KNG1 Proteins) and present novel evidence for the main effect of KNG1 (show KNG1 Proteins) gene on IS susceptibility

  4. results of the meta-analysis indicate that ALOX5AP rs10507391/SG13S114 A>T polymorphism is not associated with the risk of cerebral infarction in the Chinese population.

  5. Genetic polymorphisms of ALOX5AP and CYP3A5 (show CYP3A5 Proteins) increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.

  6. Our study provides evidence that the promoter single nucleotide polymorphism (SNP) rs17222919 of the ALOX5AP is a potential genetic protective factor for IS in the Chinese Han population.

  7. Report no association between ALOX5AP SNPs and atherosclerotic plaque phenotypes.

  8. THE 5-LOX (show ALOX5 Proteins) interface involving the four cysteines 159, 300, 416 and 418 is important for the translocation to the nuclear membrane and the colocalization with FLAP.

  9. FLAP protein inhibition attenuates inflammation induced by lipopolysaccharides (LPS (show IRF6 Proteins)) or the lipid A fraction of LPS (show IRF6 Proteins).

  10. Rs10507391, rs4769874 and its haplotypes in ALOX5AP are unrelated to ACS (show PLA2G15 Proteins) risk in the Chinese Han population of Changwu, but elevated serum LTB4 (show PTGR1 Proteins) level is strongly associated withacute coronary syndrome risk

Cow (Bovine) Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) interaction partners

  1. ALOX5AP, CPNE3 (show CPNE3 Proteins), IL1R2 (show IL1R2 Proteins), IL6 (show IL6 Proteins), TLR2, TLR4 (show TLR4 Proteins), and THY1 (show THY1 Proteins) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.

ALOX5AP Protein Profile

Protein Summary

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with ALOX5AP

  • arachidonate 5-lipoxygenase-activating protein (alox5ap)
  • arachidonate 5-lipoxygenase-activating protein (ALOX5AP)
  • Arachidonate 5-lipoxygenase-activating protein (al5ap)
  • Arachidonate 5-lipoxygenase-activating protein (flap)
  • 5-lipoxygenase-activating protein (FLAP)
  • arachidonate 5-lipoxygenase activating protein (Alox5ap)
  • al5ap protein
  • ALOX5AP protein
  • fj65d02 protein
  • FLAP protein
  • wu:fj65d02 protein
  • zgc:63982 protein

Protein level used designations for ALOX5AP

arachidonate 5-lipoxygenase-activating protein , Arachidonate 5-lipoxygenase-activating protein , MK-886-binding protein , arachidonate 5 lipoxygenase activating protein , 5-lipoxygenase-activating protein FLAP , FLAP , arachidonate 5-lipoxygenase activating protein , 5-lipoxygenase-activating protein

337376 Danio rerio
452520 Pan troglodytes
477323 Canis lupus familiaris
613083 Xenopus (Silurana) tropicalis
770904 Gallus gallus
100286557 Salmo salar
100305320 Oncorhynchus mykiss
100009413 Oryctolagus cuniculus
443326 Ovis aries
11690 Mus musculus
29624 Rattus norvegicus
241 Homo sapiens
613869 Bos taurus
100034178 Equus caballus
397392 Sus scrofa
713170 Macaca mulatta
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