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ALOX5AP encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Additionally we are shipping ALOX5AP Antibodies (64) and ALOX5AP Kits (10) and many more products for this protein.
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BRP (show GDF5 Proteins)-7 potently suppresses leukotriene biosynthesis by interacting with FLAP in mouse peritonitis model.
FLAP regulates phosphorylation of tau protein via modulating GSK-3beta activity.
This study demonistrated that a a novel role for FLAP in the pathogenesis of anxiety-like behavior in mice.
Deletion of myeloid cell FLAP markedly attenuates the proliferative response to vascular injury, while preserving endothelial integrity.
A FLAP inhibitor given during critical window periods may prevent oxygen induced aberration of pulmonary alveolarization in a dose- and time-dependent manner.
the 5-LO (show ALOX5 Proteins) pathway emerges early during embryonic stem cell differentiation into cells of the myeloid lineage
Adipose tissue from obese mice, compared with that from lean mice, exhibited increased 5-LO (show ALOX5 Proteins) activating protein
Data show that 5-lipoxygenase (show ALOX5 Proteins) activity increases during senescence-like growth arrest via a p53 (show TP53 Proteins)/p21-dependent pathway in both human and mouse embryo fibroblasts.
Altered 5-lipoxygenase (show ALOX5 Proteins) is associated with obesity and bone traits
This observation supports the hypothesis that 5-LO (show ALOX5 Proteins) may be involved in diseases of the brain associated with aging.
Genetic interaction of CD80 (show CD80 Proteins) and ALOX5AP was observed in systemic lupus erythematosus in Asian populations.
findings show that several enzymes known to be involved in the biosynthesis of proinflammatory LTs, such as FLAP and cPLA2alpha (show PLA2G4A Proteins), also contribute to LX and Rv formation
The results of this study supported the association of the epistatic interactions of ALOX5AP, THBD (show THBD Proteins), and KNG1 (show KNG1 Proteins) and present novel evidence for the main effect of KNG1 (show KNG1 Proteins) gene on IS susceptibility
results of the meta-analysis indicate that ALOX5AP rs10507391/SG13S114 A>T polymorphism is not associated with the risk of cerebral infarction in the Chinese population.
Genetic polymorphisms of ALOX5AP and CYP3A5 (show CYP3A5 Proteins) increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.
Our study provides evidence that the promoter single nucleotide polymorphism (SNP) rs17222919 of the ALOX5AP is a potential genetic protective factor for IS in the Chinese Han population.
Report no association between ALOX5AP SNPs and atherosclerotic plaque phenotypes.
THE 5-LOX (show ALOX5 Proteins) interface involving the four cysteines 159, 300, 416 and 418 is important for the translocation to the nuclear membrane and the colocalization with FLAP.
FLAP protein inhibition attenuates inflammation induced by lipopolysaccharides (LPS (show IRF6 Proteins)) or the lipid A fraction of LPS (show IRF6 Proteins).
Rs10507391, rs4769874 and its haplotypes in ALOX5AP are unrelated to ACS (show PLA2G15 Proteins) risk in the Chinese Han population of Changwu, but elevated serum LTB4 (show PTGR1 Proteins) level is strongly associated withacute coronary syndrome risk
ALOX5AP, CPNE3 (show CPNE3 Proteins), IL1R2 (show IL1R2 Proteins), IL6 (show IL6 Proteins), TLR2, TLR4 (show TLR4 Proteins), and THY1 (show THY1 Proteins) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
arachidonate 5-lipoxygenase-activating protein
, Arachidonate 5-lipoxygenase-activating protein
, MK-886-binding protein
, arachidonate 5 lipoxygenase activating protein
, 5-lipoxygenase-activating protein FLAP
, arachidonate 5-lipoxygenase activating protein
, 5-lipoxygenase-activating protein