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ALOX5AP Products

(Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP))
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].

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Featured ALOX5AP Categories

ALOX5AP Antibodies

High quality antibodies with extensive validation data.

ALOX5AP ELISA Kits

Reliable ELISA kits for a wide range of species.

ALOX5AP Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ALOX5AP Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (3)
Cat. No. ABIN185717
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (3)
Cat. No. ABIN185249
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (2)
Cat. No. ABIN2157693
Quantity 400 μL
Datasheet Datasheet

Recommended ALOX5AP ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964996
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730404
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1122348
Quantity 96 tests
Datasheet Datasheet

Recommended ALOX5AP Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133653
Quantity 0.25 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3088606
Quantity 0.5 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1344923
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our ALOX5AP products

Schmider, Vaught, Bauer, Elliott, Godin, Ellis, Nigrovic, Soberman: "The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses." in: PLoS ONE, Vol. 14, Issue 2, pp. e0211943, (2019) (PubMed).

Huang, Sharifpanah, Becker, Wartenberg, Sauer: "Impact of Arachidonic Acid and the Leukotriene Signaling Pathway on Vasculogenesis of Mouse Embryonic Stem Cells." in: Cells, tissues, organs, Vol. 201, Issue 5, pp. 319-32, (2016) (PubMed).

Elias, Ferré, Vilà, Muñoz, Casellas, Garcia, Molas, Agudo, Roca, Ruberte, Bosch, Franckhauser: "ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance." in: Diabetes, Vol. 65, Issue 8, pp. 2139-50, (2016) (PubMed).

van der Laan, Foroughi Asl, van den Borne, van Setten, van der Perk, van de Weg, Schoneveld, de Kleijn, Michoel, Björkegren, den Ruijter, Asselbergs, de Bakker, Pasterkamp: "Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study." in: Atherosclerosis, Vol. 239, Issue 2, pp. 528-38, (2015) (PubMed).

Zhang, Yu, Ni, Shen, Das: "Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes." in: PLoS ONE, Vol. 10, Issue 4, pp. e0123256, (2015) (PubMed).

Perisic, Hedin, Razuvaev, Lengquist, Osterholm, Folkersen, Gillgren, Paulsson-Berne, Ponten, Odeberg, Hedin: "Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 33, Issue 10, pp. 2432-43, (2013) (PubMed).

Finkensieper, Kieser, Bekhite, Richter, Mueller, Graebner, Figulla, Sauer, Wartenberg: "The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells." in: Cardiovascular research, Vol. 86, Issue 1, pp. 37-44, (2010) (PubMed).

Maier, Tausch, Hoernig, Coste, Schmidt, Angioni, Metzner, Groesch, Pergola, Steinhilber, Werz, Geisslinger: "Celecoxib inhibits 5-lipoxygenase." in: Biochemical pharmacology, Vol. 76, Issue 7, pp. 862-72, (2008) (PubMed).

Kaaman, Rydén, Axelsson, Nordström, Sicard, Bouloumié, Langin, Arner, Dahlman: "ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance." in: International journal of obesity (2005), Vol. 30, Issue 3, pp. 447-52, (2006) (PubMed).

Helgadottir, Manolescu, Thorleifsson, Gretarsdottir, Jonsdottir, Thorsteinsdottir, Samani, Gudmundsson, Grant, Thorgeirsson, Sveinbjornsdottir, Valdimarsson, Matthiasson, Johannsson, Gudmundsdottir et al.: "The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. ..." in: Nature genetics, Vol. 36, Issue 3, pp. 233-9, (2004) (PubMed).

Synonyms and alternative names related to ALOX5AP

arachidonate 5-lipoxygenase-activating protein (alox5ap), arachidonate 5-lipoxygenase activating protein (ALOX5AP), arachidonate 5-lipoxygenase activating protein (alox5ap), arachidonate 5-lipoxygenase activating protein (Alox5ap), al5ap, Alox5ap, ALOX5AP, fj65d02, flap, Flap, FLAP, wu:fj65d02, zgc:63982

Protein level used designations for ALOX5AP

  • arachidonate 5-lipoxygenase-activating protein
  • Arachidonate 5-lipoxygenase-activating protein
  • MK-886-binding protein
  • arachidonate 5 lipoxygenase activating protein
  • 5-lipoxygenase-activating protein FLAP
  • FLAP
  • arachidonate 5-lipoxygenase activating protein
  • 5-lipoxygenase-activating protein
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