anti-Aspartoacylase (ASPA) Antibodies

ASPA encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. Additionally we are shipping ASPA Proteins (14) and ASPA Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ASPA 443 P45381
ASPA 11484 Q8R3P0
ASPA 79251 Q9R1T5
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Top anti-ASPA Antibodies at

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ASPA Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human kidney 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-ASPA Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of ASPA Antibody (N-term) (ABIN390843) in MCF7 cell line lysates (35 µg/lane). ASPA (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human skeletal muscle reacted with ASPA Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged ASPA is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB   0.4 mL Log in to see 12 to 15 Days
Mouse Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Immunohistochemistry-Paraffin: ASPA Antibody [NBP1-31754] - Paraffin-embedded Cal27 xenograft, using antibody at 1:100 dilution. Western Blot: ASPA Antibody [NBP1-31754] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Aspartoacylase antibody diluted by 1:1000. 100 μL Log in to see 7 to 9 Days
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ICC, IF, WB Western Blot: ASPA Antibody [NBP2-15491] - Sample (20 ug of whole cell lysate) A: Mouse brain 10% SDS PAGE gel, diluted at 1:10000. Immunocytochemistry/Immunofluorescence: ASPA Antibody [NBP2-15491] - Analysis of paraformaldehyde-fixed HeLa, using antibody at 1:500 dilution. 0.1 mL Log in to see 8 to 11 Days

ASPA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
Mouse (Murine)

, , , , ,
Rat (Rattus)

Top referenced anti-ASPA Antibodies

  1. Human Monoclonal ASPA Primary Antibody for ELISA, WB - ABIN393318 : Joslyn, Ravindranathan, Brush, Schuckit, White: Human variation in alcohol response is influenced by variation in neuronal signaling genes. in Alcoholism, clinical and experimental research 2010 (PubMed)
    Show all 5 references for 393318

  2. Cow (Bovine) Polyclonal ASPA Primary Antibody for WB - ABIN2786497 : Le Coq, Pavlovsky, Malik, Sanishvili, Xu, Viola: Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue. in Biochemistry 2008 (PubMed)

  3. Human Polyclonal ASPA Primary Antibody for FACS, IF - ABIN390843 : Bitto, Bingman, Wesenberg, McCoy, Phillips: Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

More Antibodies against ASPA Interaction Partners

Human Aspartoacylase (ASPA) interaction partners

  1. report of 2 Egyptian sibling patients suspected of Canavan disease (CD); study revealed homozygosity for substitution T530C (Ile177Thr) in exon 4 of the ASPA gene in both sibs; substitution T530C (Ile177Thr) results in a novel missense mutation causing a CD phenotype with severe clinical characteristics

  2. Four ASPA missense mutations associated with Canavan disease are structurally characterized.

  3. Definitive evidence is presented to show that the recombinantly-expressed human aspartoacylase is not a glycoprotein.

  4. This is the first case report of ASPA mutation studies in Canavan disease from Indian subcontinent.

  5. a novel mutation Y88X within the aspartoacylase gene in a consanguineous family with an affected child diagnosed as Canavan disease.

  6. Human aspartoacylase gene expression was high not only in brain and kidney, but also in lung and liver.

  7. Gene ASPA (NM_000049) was undertaken to sequence for mutation analysis.

  8. We report on an Italian female patient with Canavan disease due to a missense mutation of the aspartoacylase gene and a 17p13.3 chromosomal microdeletion

  9. the ASPA gene was analysed in 22 unrelated non-Jewish patients with Canavan disease, and 24 different mutations were found

  10. Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene

Mouse (Murine) Aspartoacylase (ASPA) interaction partners

  1. Gata6 (show GATA6 Antibodies) regulates differentiation, metabolism, and survival of resident peritoneal macrophages through aspartoacylase.

  2. aspartoacylase is proposed here to support lipid synthesis and energy metabolism via the provision of substrate for both cellular processes during early postnatal development

  3. Intracellular vacuolisation in astrocytes coincides with axonal swellings in cerebellum and brain stem of aspa(lacZ/lacZ (show GLB1 Antibodies)) mutants indicating that astroglia may act as an osmolyte buffer in the aspa-deficient CNS

  4. Aspa defects were associated with increased levels of acetylated histone H3 (show HIST3H3 Antibodies), decreased chromatin compaction and increased GFAP (show GFAP Antibodies) protein, a marker for astrogliosis. Early in postnatal development ASPA defic affects oligodendrocyte maturation and myelination

  5. Death of OLs, neurons, and astrocytes was identified in every region of the aspartoacylase KO brain. These findings support involvement of ASPA in CNS development and function.

  6. ASPA gene defect in the mouse leads to spinal cord pathology; these changes may be involved in the cause of the physiological/behavioral abnormalities seen in the knockout mouse.

  7. normal hydrolysis of N-acetylaspartic acid is affected by aspartoacylase activity seen in the type 2 diabetes model mouse

  8. we now present immunoblot, proteomic, and biochemical evidence that the membrane-bound form of ASPA is intrinsic to purified myelin membranes.

  9. Nur7( Q193X) is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS.

ASPA Antigen Profile

Protein Summary

This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with anti-Aspartoacylase (ASPA) Antibodies

  • aspartoacylase (ASPA) antibody
  • aspartoacylase (aspa) antibody
  • Aspartoacylase (Fbal_2465) antibody
  • aspartoacylase (Aspa) antibody
  • Acy-2 antibody
  • Acy2 antibody
  • ASP antibody
  • nur7 antibody
  • zgc:171507 antibody

Protein level used designations for anti-Aspartoacylase (ASPA) Antibodies

aspartoacylase (Canavan disease) , Aminoacylase-2 , aspartoacylase (aminoacylase 2, Canavan disease) , Aspartoacylase , ACY-2 , aminoacylase 2 , aminoacylase-2 , aspartoacylase (aminoacylase) 2

454430 Pan troglodytes
706170 Macaca mulatta
733935 Xenopus (Silurana) tropicalis
9771274 Ferrimonas balearica DSM 9799
509432 Bos taurus
100142661 Sus scrofa
443 Homo sapiens
100173374 Pongo abelii
11484 Mus musculus
79251 Rattus norvegicus
557232 Danio rerio
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