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Bromodomain Containing 4 Proteins (BRD4)

The protein encoded by BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Additionally we are shipping BRD4 Antibodies (84) and BRD4 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRD4 23476 O60885
BRD4 57261 Q9ESU6
Rat BRD4 BRD4 362844  
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Top BRD4 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 3 to 4 Days
$253.00
Details
HOST_Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant BRD4 (333-460) activity using AlphaScreen. BRD4 (333-460) titration and inhibition were assessed using an AlphaScreen® assay. Titration curves were generated to show signal response in the presence of modified peptide substrate at increasing protein concentrations. An IC50 dose response assessment of reference compounds JQ1, I-BET151, Bromosporine and PFI-1 is also shown. This data was generated and kindly provided courtesy of ChemPartner. Recombinant BRD4 (333-460) protein gel. BRD4 (333-460) protein was run on an SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
$460.83
Details

BRD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human
,
Mouse (Murine)

More Proteins for Bromodomain Containing 4 (BRD4) Interaction Partners

Zebrafish Bromodomain Containing 4 (BRD4) interaction partners

  1. Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis

Human Bromodomain Containing 4 (BRD4) interaction partners

  1. HPV16 E2-Brd4 interaction is more responsible for the transcriptional activation of host genes rather than repression.

  2. combined administration of lenalidomide and BRD4 inhibitor JQ-1 significantly increased the survival of PEL bearing NOD-SCID (show PRKDC Proteins) mice in an orthotopic xenograft model

  3. findings identify key structural features of the ET domain of Brd4 that allow for interactions with both cellular and viral proteins.

  4. we found that NF-kappaB (show NFKB1 Proteins), BRD4 and RNA POL II were rapidly distributed at the upstream regions of miR (show MLXIP Proteins)-146a and miR (show MLXIP Proteins)-155, and more importantly mediated the formation of the super enhancers that drive miR (show MLXIP Proteins)-146a and miR (show MLXIP Proteins)-155 transcription.

  5. In conclusion, our findings revealed that the aberrant expression of BRD4 in thyroid cancer is possibly involved in tumor progression, and JQ1 is potentially an effective chemotherapeutic agent against human thyroid cancer.

  6. novel actions of BRD4 and of NELF-E (show RDBP Proteins) in GR-controlled gene induction have been uncovered.

  7. Brd4 is a novel client protein of Hsp90 (show HSP90 Proteins), which protects Brd4 from degradation and contributes to the upregulation of Brd4 in cystic renal epithelial cells and tissues.

  8. Study provides evidence that links the CHD8 chromatin remodeler to the cancer maintenance functions of BRD4 and NSD3 (show WHSC1L1 Proteins).

  9. the BRD4 inhibition can inhibit joint inflammation and FBS-induced migration and invasion of human RA-FLS via decreasing the phosphorylation of c-Jun and activation of NFkappaB.

  10. This study implicates BET Brds as important regulators of IkappaB kinase (show CHUK Proteins)/NF-kappaB (show NFKB1 Proteins)-mediated synovial inflammation of RA and identifies BET proteins as novel therapeutic targets in inflammatory arthritis.

Mouse (Murine) Bromodomain Containing 4 (BRD4) interaction partners

  1. our data demonstrate the fundamental role of Brd4 in monitoring cell differentiation through its interaction with acetylated histone marks and disruption of Brd4 may cause aberrant differentiation.

  2. Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Proteins)) directly regulates Kruppel-like factor 4 (Klf4 (show KLF4 Proteins)) expression and increasing the levels of histone demethylase Lsd1 (show KDM1A Proteins) and transcription factor Brd4 in B cell.

  3. BRD4 can act as a global genomic regulator to direct the fibrotic response through its coordinated regulation of myofibroblast transcription.

  4. BRD4 is critical for the maintenance of ESC pluripotency and that this occurs primarily through the maintenance of Nanog expression.

  5. The BET family member BRD4 interacts with OCT4 (show POU5F1 Proteins) and regulates pluripotency gene expression

  6. Brd4 provides a critical link between neuronal activation and the transcriptional responses that occur during memory formation

  7. Aire's collaboration with the bromodomain-containing protein, Brd4, uncovered correspondence between those genes induced by Aire (show AIRE Proteins) and those inhibited by a small-molecule bromodomain blocker.

  8. Data suggest that Brd4 is essential for Toll (show TLR4 Proteins)-like receptor-stimulated interferon-beta (IFNB (show IFNB1 Proteins)) gene transcription by permitting transcription factors to interact with the IFNB (show IFNB1 Proteins) promoter in macrophages.

  9. Data show that hematopoietic transcription factors (TFs) promote bromodomain containing 4 protein (BRD4) recruitment to their occupied sites.

  10. BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers, regulates the self-renewal ability and pluripotency of ESCs (show NR2E3 Proteins).

BRD4 Protein Profile

Protein Summary

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.

Gene names and symbols associated with BRD4

  • bromodomain containing 4 (brd4)
  • bromodomain containing 4 (BRD4)
  • bromodomain containing 4 (Brd4)
  • BRD4 protein
  • brd4-b protein
  • Brd5 protein
  • CAP protein
  • fb18g03 protein
  • HUNK1 protein
  • HUNKI protein
  • MCAP protein
  • WI-11513 protein
  • wu:fb18g03 protein

Protein level used designations for BRD4

Bromodomain-containing protein 4B , bromodomain-containing protein 4B , bromodomain containing 4 , bromodomain-containing protein 4 , bromodomain 4 , bromodomain-containing protein 4-like , bromodomain containing protein 4 , bromodomain-containing 4 , chromosome-associated protein , bromodomain-containing 5 , fsh-like protein , mitotic chromosome-associated protein

GENE ID SPECIES
446381 Xenopus laevis
455794 Pan troglodytes
570531 Danio rerio
100062072 Equus caballus
100216259 Xenopus (Silurana) tropicalis
100409351 Callithrix jacchus
100463607 Ailuropoda melanoleuca
100074736 Ornithorhynchus anatinus
100352214 Oryctolagus cuniculus
100533540 Sus scrofa
100593625 Nomascus leucogenys
23476 Homo sapiens
484869 Canis lupus familiaris
614048 Bos taurus
57261 Mus musculus
362844 Rattus norvegicus
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