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C-terminal Binding Protein 2 Proteins (CTBP2)

CTBP2 produces alternative transcripts encoding two distinct proteins. Additionally we are shipping CTBP2 Antibodies (88) and CTBP2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTBP2 1488 P56545
CTBP2 13017 P56546
CTBP2 81717 Q9EQH5
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Top CTBP2 Proteins at

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CTBP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

Top referenced CTBP2 Proteins

  1. Human CTBP2 Protein expressed in Human - ABIN2712602 : Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014 (PubMed)

More Proteins for C-terminal Binding Protein 2 (CTBP2) Interaction Partners

Human C-terminal Binding Protein 2 (CTBP2) interaction partners

  1. Our results indicated that CCNH (show CCNH Proteins)/CDK7 (show CDK7 Proteins)-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma .

  2. Releasing the key adipogenic regulator C/EBPalpha (show CEBPA Proteins) from CtBP2 binding.

  3. Enhanced CtBP2expression promoted HCC (show FAM126A Proteins) xenograft growth and induced EMT (show ITK Proteins).

  4. results show how CtBP2 contributes to prostate cancer progression by modulating AR and oncogenic signaling

  5. High CTBP2 expression is associated with prostate cancer.

  6. Overexpression of CtBP2 is associated with breast carcinoma.

  7. CtBP2 might contribute to the progression of esophageal squamous cell carcinoma through a negative transcriptional regulation of p16(INK4A).

  8. CtBP2 is over-expressed in prostate cancer.CtBP2 promotes prostate cancer cell proliferation through c-Myc (show MYC Proteins) signaling.

  9. Crystal structures of human CtBP1 (show CTBP1 Proteins) and CtBP2 in complex with 4-Methylthio 2-oxobutyric acid and NAD.

  10. BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2.CtBP2 is an ovarian cancer oncogene (show RAB1A Proteins).

Mouse (Murine) C-terminal Binding Protein 2 (CTBP2) interaction partners

  1. Ctbp2 preoccupies regions in active genes with the NuRD complex in undifferentiated ESCs (show NR2E3 Proteins) that are directed toward H3K27me3 by PRC2 to induce stable silencing, which is pivotal for natural lineage commitment.

  2. Phosphorylation of KLF3 (show KLF3 Proteins) and CtBP2 by HIPK2 (show HIPK2 Proteins) strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (show KLF3 Proteins).

  3. propose that Zscan4 (show ZSCAN4 Proteins) may regulate gene transcription in mouse ES cells through interaction with LSD1 (show KDM1A Proteins) and CtBP2

  4. RIBEYE(B) interacts with ArfGAP3 (show ARFGAP3 Proteins) in vivo and in vitro.

  5. CTBP2 is indispensable to create a chromatin environment conducive for RAR (show RARA Proteins)/RXR-mediated transcription by recruiting the histone acetyltransferase p300 (show EP300 Proteins).

  6. Study demonstrates differential regional and subcellular expression patterns for the two CtBP family members in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions.

  7. Ctbp2 has a role in maintaining a balance in decisions to self-renewal and differentiate in embryonic stem cells and mesodermal progenitors

  8. Mice harboring various combinations of Ctbp1 (show CTBP1 Proteins) and Ctbp2 mutant alleles exhibit dosage-sensitive defects in a wide range of developmental processes

  9. The CtBP2 co-repressor function is regulated by an NADH-dependent effect on CtBP2 dimerization.

  10. calsenilin (show KCNIP3 Proteins) and CtBP2 are present in synaptic vesicles and can interact in vivo

Zebrafish C-terminal Binding Protein 2 (CTBP2) interaction partners

  1. In photoreceptor cells, RIBEYE and RIM2 (show RIMS2 Proteins) are expressed along the synaptic ribbon.

Xenopus laevis C-terminal Binding Protein 2 (CTBP2) interaction partners

  1. Tcf-3 (show TCF3 Proteins) functions as a transcriptional regulator in the canonical Wnt (show WNT2 Proteins) signaling cascade and can repress or activate downstream target genes. The tcf-3 (show TCF3 Proteins) promoter was analyzed during early development of Xenopus.

  2. Together, these results demonstrate that signaling through Tcf (show HNF4A Proteins) and Vent binding sites regulates transcription of geminin (show GMNN Proteins) in prospective neurectoderm during gastrulation

CTBP2 Protein Profile

Protein Summary

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3\; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.

Gene names and symbols associated with CTBP2

  • C-terminal binding protein 2 (ctbp2)
  • C-terminal binding protein 2 (CTBP2)
  • C-terminal binding protein 2 (Ctbp2)
  • AA407280 protein
  • ctbp protein
  • ctbp-b protein
  • D7Ertd45e protein
  • fe05b01 protein
  • Gtrgeo6 protein
  • Ribeye protein
  • wu:fb96g03 protein
  • wu:fe05b01 protein
  • wu:fk19e02 protein
  • xctbp protein

Protein level used designations for CTBP2

C-terminal binding protein 2 , C-terminal-binding protein 2-like , C-terminal-binding protein 2 , ribeye , gene trap ROSA b-geo 6 , ribeye a , C-terminal-binding protein B , TCF-3 corepressor CtBP , Tcf-3 co-repressor CtBP , XCtBP

493558 Xenopus (Silurana) tropicalis
100398309 Callithrix jacchus
423958 Gallus gallus
1488 Homo sapiens
100684514 Canis lupus familiaris
281730 Bos taurus
13017 Mus musculus
81717 Rattus norvegicus
65230 Danio rerio
398147 Xenopus laevis
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