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CTLA4 Proteins

(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].

recommended

CTLA4 Protein (Fc Tag) (ABIN7274436)

CTLA4 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC

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recommended

CTLA4 Protein (mFc-His Tag) (ABIN6961090)

CTLA4 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS

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recommended

CTLA4 Protein (His tag) (ABIN7274435)

CTLA4 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC

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CTLA4 Proteins by Grade

Find CTLA4 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

CTLA4 Proteins by Origin

Find CTLA4 Proteins for a variety of species such as anti-Human CTLA4, anti-Mouse CTLA4, anti-Cynomolgus CTLA4. The species listed below are among those available. Click on a link to go to the corresponding products.

CTLA4 Proteins by Source

Find CTLA4 Proteins with a specific Source. The Source listed below are among those available. Click on a link to go to the corresponding products.

CTLA4 Proteins by Protein Type

Find CTLA4 Proteins with a specific Protein Type. The Protein Type listed below are among those available. Click on a link to go to the corresponding products.

CTLA4 Proteins by Application

Find CTLA4 Proteins validated for a specific application such as WB, ELISA, SDS, MS. Some of the available applications are listed below. Click on a link to go to the corresponding products.

CTLA4 Proteins by Biological Activity

Find CTLA4 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular CTLA4 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

CTLA4 Protein (Fc Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7274436

Quantity 100 μg

Datasheet Datasheet

CTLA4 Protein (mFc-His Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN6961090

Quantity 100 μg

Datasheet Datasheet

CTLA4 Protein (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7274435

Quantity 100 μg

Datasheet Datasheet

CTLA4 Protein (His-Avi Tag,Biotin)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7274437

Quantity 100 μg

Datasheet Datasheet

CTLA4 Protein (His tag)

Reactivity Cynomolgus

Source HEK-293 Cells

Validations

Cat. No. ABIN7274434

Quantity 100 μg

Datasheet Datasheet

CTLA4 Protein (AA 37-162) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2487344

Quantity 100 μg

Datasheet Datasheet

CTLA4 Protein (AA 36-162) (His tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN2870729

Quantity 200 μg

Datasheet Datasheet

CTLA4 Protein (AA 37-160) (Fc Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2180932

Quantity 200 μg

Datasheet Datasheet

CTLA4 Protein (AA 37-162) (Fc Tag,AVI tag,Biotin)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2870534

Quantity 200 μg

Datasheet Datasheet

CTLA4 Protein (AA 36-162) (Fc Tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN2870731

Quantity 200 μg

Datasheet Datasheet

CTLA4 Protein (AA 37-160) (His tag)

Reactivity Cynomolgus, Rhesus Monkey

Source HEK-293 Cells

Validations

Cat. No. ABIN2180926

Quantity 200 μg

Datasheet Datasheet

CTLA4 Protein (AA 36-161) (Fc Tag)

Reactivity Rabbit

Source HEK-293 Cells

Validations

Cat. No. ABIN4949199

Quantity 100 μg

Datasheet Datasheet

CTLA4 Protein (AA 36-162) (His tag,AVI tag,Biotin)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN6973042

Quantity 200 μg

Datasheet Datasheet

CTLA4 Protein (AA 37-160) (His tag,AVI tag,Biotin)

Reactivity Cynomolgus, Rhesus Monkey

Source HEK-293 Cells

Validations

Cat. No. ABIN2180929

Quantity 200 μg

Datasheet Datasheet

CTLA4 Protein (AA 37-162) (Strep Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN6810026

Quantity 1 mg

Datasheet Datasheet

Latest Publications for our CTLA4 Proteins

Bai, Gao, Hu, Liu, Li, Dong, Huang, Zhu, Zhou, Li, Shao: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).

Simons, Lim, Carter, Wagner, Wayham, Adler, Johnson: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).

Okada, Kajiya, Omata, Matsumoto, Sato, Kobayashi, Nakamura, Kaneko, Nakamura, Koyama, Sudo, Shin, Okamoto, Watanabe, Tachibana, Hirose, Saito, Takai, Matsumoto, Nakamura, Okabe, Miyamoto, Tanaka: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).

Ganesan, Moon, Barakat: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." in: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).

Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

Ganesan, Ahmed, Okoye, Arutyunova, Babu, Turnbull, Kundu, Shields, Agopsowicz, Xu, Tabana, Srivastava, Zhang, Moon, Belovodskiy, Hena, Kandadai, Hosseini, Hitt, Walker, Smylie, West, Siraki, Lemieux et al.: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).

Zhao, Lee, Lin, Gassen, Xu, Huang, Xiao, Bonorino, Lu, Bui, Hui: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).

Waight, Chand, Dietrich, Gombos, Horn, Gonzalez, Manrique, Swiech, Morin, Brittsan, Tanne, Akpeng, Croker, Buell, Stein, Savitsky, Wilson: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." in: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).

Ljungars, Svensson, Carlsson, Birgersson, Tornberg, Frendéus, Ohlin, Mattsson: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).

Aliases for CTLA4 Proteins

cytotoxic T-lymphocyte associated protein 4 (CTLA4) Proteins
cytotoxic T-lymphocyte-associated protein 4 (Ctla4) Proteins
CD Proteins
CD152 Proteins
Cd152 Proteins
CELIAC3 Proteins
CTLA-4 Proteins
Ctla-4 Proteins
CTLA4 Proteins
GRD4 Proteins
GSE Proteins
IDDM12 Proteins
Ly-56 Proteins
sCTLA4 Proteins

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CTLA4 Proteins by Grade

CTLA4 Proteins by Origin

CTLA4 Proteins by Source

CTLA4 Proteins by Protein Type

CTLA4 Proteins by Application

CTLA4 Proteins by Biological Activity

Popular CTLA4 Proteins

Latest Publications for our CTLA4 Proteins

Aliases for CTLA4 Proteins

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