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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Additionally we are shipping CTCF Antibodies (91) and CTCF Proteins (11) and many more products for this protein.
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We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (show RUNX1 ELISA Kits) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis.
CTCF mediates local regulatory interactions to coordinate transcriptional programs controlling transitions in morphology and function during heart development.
Long-range promoter-enhancer interaction mediated by CTCF plays important roles in controlling the cell-to-cell variation of gene expression in mammalian cells.
n keratinocytes, the promoter-enhancer anchoring regions in the gene-rich transcriptionally active TADs are enriched for the binding of chromatin architectural proteins CTCF, Rad21 (show RAD21 ELISA Kits) and chromatin remodeler Brg1 (show SMARCA4 ELISA Kits). In contrast to gene-rich TADs, gene-poor TADs show preferential spatial contacts with each other, do not contain active enhancers and show decreased binding of CTCF, Rad21 (show RAD21 ELISA Kits) and Brg1 (show SMARCA4 ELISA Kits) in keratinocytes
CTCF mediated chromatin structural modulation and regulates Hoxc gene expression.
CTCF can regulate V(D)J recombination by segregating recombination signal sequences (RSSs) into distinct loop domains and inhibiting RSS (show GRB10 ELISA Kits) synapsis, independent of any effects on transcription, RSS (show GRB10 ELISA Kits) accessibility, and RAG recombinase (show RAG1 ELISA Kits) tracking
this study shows that CTCF serves to translate alpha-ketoglutarate-sensitive metabolic changes into context-dependent differentiation gene programs
CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.
ERCC1 (show ERCC1 ELISA Kits)-XPF (show ERCC4 ELISA Kits) cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes and that persistent DNA damage triggers chromatin changes that affect gene expression programs associated with NER (show NR1H2 ELISA Kits) disorders.
BRD2 (show BRD2 ELISA Kits) acts to augment the boundary function of CTCF both by limiting the spread or range of enhancer activity and by physically preventing the formation of cross-boundary contacts genome-wide.
Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice has been reported.
CTCF-mediated long-range interactions are integral for a multitude of topological features of interphase chromatin, such as the formation of topologically associated domains, domain insulation, enhancer blocking and even enhancer function.
Authors have identified two novel pro-tumorigenic roles (promoting cell survival and altering cell polarity) for genetic alterations of CTCF in endometrial cancer.
Describe several protein-DNA complex structures of a human CTCF tandem zinc-finger array, explaining the adaptability of CTCF to sequence variations and the positiondependent effect of differential DNA methylation (show HELLS ELISA Kits) at two cytosine residues, and revealing a potential function of C-terminal ZF8 and ZF9 (show KLF6 ELISA Kits) spanning across the DNA phosphate backbone.
CCCTC-binding factor (CTCF) targets the binding sites within MYCN (show MYCN ELISA Kits) promoter to facilitate its expression in neuroblastoma (show ARHGEF16 ELISA Kits) (NB) cells.
we review recent high-resolution chromosome conformation capture and functional studies that have informed models of the spatial and regulatory compartmentalization of mammalian genomes, and discuss mechanistic models for how CTCF and cohesin control the functional architecture of mammalian chromosomes.
GAD1 (show GAD1 ELISA Kits) is reactivated by DNA methylation (show HELLS ELISA Kits), which provided a model for DNA methylation (show HELLS ELISA Kits) and the active orchestration of oncogenic gene expression by CTCF in cancer cells.
epigenetic factor CTCF-mediated chromatin remodeling regulates interactions between eye-specific PAX6 (show PAX6 ELISA Kits) and those genes that are induced/associated with cell differentiation to modulate corneal epithelial cell-specific differentiation
Rta (show RBM9 ELISA Kits)-mediated decreased binding of CTCF in the viral genome is concurrent with virus reactivation. Via interfering with CTCF binding, in the host genome Rta (show RBM9 ELISA Kits) can function as a transcriptional repressor for gene silencing.
although we were unable to detect HD-associated DNA methylation (show HELLS ELISA Kits) alterations at queried sites, we found that DNA methylation (show HELLS ELISA Kits) may be correlated to the age of disease onset in cortex tissues. Moreover, our data suggest that DNA methylation (show HELLS ELISA Kits) may, in part, contribute to tissue-specific HTT (show HTT ELISA Kits) transcription through differential CTCF occupancy.
Data support the hypothesis that CTCF and cohesin SA-1 (show STAG1 ELISA Kits) have multiple roles in the regulation of gene expression during erythropoiesis.
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor