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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Additionally we are shipping CTCF Antibodies (87) and CTCF Proteins (11) and many more products for this protein.
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We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (show RUNX1 ELISA Kits) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis.
deletion of CTCF (CCCTC-binding factor)-binding sites at TAD (show CRTAM ELISA Kits) and sub-TAD (show CRTAM ELISA Kits) topological boundaries that form within the HoxA and HoxC clusters during differentiation not only disturbs local chromatin domain organization and regulatory interactions but also results in homeotic transformations typical of Hox (show MSH2 ELISA Kits) gene misregulation
Our study also identified the imprinting control region (ICR) of H19 (show NCKAP1 ELISA Kits) as a genomic target. According to the results, PEG3 (show PEG3 ELISA Kits) binds to a specific sequence motif located between the 3(rd) and 4(th) CTCF binding sites of the H19 (show NCKAP1 ELISA Kits)-ICR. PEG3 (show PEG3 ELISA Kits) also binds to the active maternal allele of the H19 (show NCKAP1 ELISA Kits)-ICR.
Using circular chromosome conformation capture sequencing, we systematically examined the interacting loci of a Bmal1 (show ARNTL ELISA Kits)-bound super-enhancer upstream of a clock gene Nr1d1 (show NR1D1 ELISA Kits) in mouse liver. Global analysis showed that cohesin-CTCF co-binding sites tend to insulate the phases of circadian oscillating genes while cohesin-non-CTCF sites are associated with high circadian rhythmicity of transcription.
data demonstrate a reciprocal relationship between Hmgb2 (show HMGB2 ELISA Kits) and Ctcf in controlling aspects of chromatin structure and gene expression.
in addition to mediating long-range chromatin interactions, CTCF influences intricate configuration of chromatin loops that govern functional interactions between elements.
TGF-beta (show TGFB1 ELISA Kits)/beta2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.
Results indicate that CTCF binding polarity plays a functional role in the formation of higher-order chromatin structure.
Firre is X-linked and expressed from a macrosatellite repeat locus associated with a cluster of CTCF and cohesin binding sites, and is preferentially located adjacent to the nucleolus
CTCF controls the homeostatic maintenance and migration of Langerhans cells.
MyoD (show MYOD1 ELISA Kits) affects chromatin looping at CCCTC-binding factor-binding sites represents the first evidence that a differentiation factor regulates chromatin-loop dynamics
vitamin D-sensitive CTCF sites provide further mechanistic details to the epigenome-wide understanding of 1,25(OH)2D3-mediated gene regulation
These findings indicate that erythroid specific activator GATA-1 (show GATA1 ELISA Kits) acts at CTCF sites around the beta-globin (show HBB ELISA Kits) locus to establish tissue-specific chromatin organization.
TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank TADs.
CTCF binding to eRNAs and promoters is facilitated by estrogen when chromatin establishes contacts with nuclear lamina.
we investigated the cell-type specificities of CTCF sites related to these functions across five cell types. Our study provides new insights into the multivalent functions of CTCF in the human genome
The results indicate that the initial chromatin conformation affects subsequent RA-induced HOXA gene activation. Our study uncovers that a removable insulator spatiotemporally switches higher-order chromatin and multiple gene activities via cooperation of CTCF and key transcription factors.
we find no evidence for selection driving these distinctive patterns of mutation. The mutational load at CTCF-binding sites is substantially determined by replication timing and the mutational signature of the tumor in question, suggesting that selectively neutral processes underlie the unusual mutation patterns.
Study described the formation of mutually exclusive complexes of ENY2 (show ENY2 ELISA Kits) with insulator proteins and Sgfl1-a component of the SAGA complex, direct binding partner for ENY2 (show ENY2 ELISA Kits)
This is supported by the depletion of CTCF in glioblastoma cells affecting the expression levels of NOTCH2 (show NOTCH2 ELISA Kits) as a target of miR (show MLXIP ELISA Kits)-181c. CONCLUSION: Together, our results point to the epigenetic role of CTCF in the regulation of microRNAs implicated in tumorigenesis
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor