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NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971 [PubMed 5552408]).[supplied by OMIM, Mar 2008].. Additionally we are shipping CD177 Antibodies (129) and CD177 Kits (6) and many more products for this protein.
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Human CD177 Protein expressed in HEK-293 Cells - ABIN2180708
Temerinac, Klippel, Strunck, Röder, Lübbert, Lange, Azemar, Meinhardt, Schaefer, Pahl: Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. in Blood 2000
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Human CD177 Protein expressed in Human Cells - ABIN2006208
Kissel, Santoso, Hofmann, Stroncek, Bux: Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions. in European journal of immunology 2001
Data indicate that high percentage of CD177 antigen-positive neutrophils undergo dynamic change during sepsis.
the CD177 SNP is the primary genetic determinant for HNA-2 deficiency and expression variations. The mechanistic delineation of HNA-2 genetics will enable the development of genetic tests for diagnosis and prognosis of HNA-2-related human diseases.
This is the first report showing a prognostic correlation between CD177 expression and solid tumor behavior.
Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders.
CD177/PECAM-1 (show PECAM1 Proteins) adhesive interaction, while contributing to neutrophil-endothelial cell interaction in neutrophil transendothelial migration, does not contribute to or is redundant in platelet-neutrophil interactions
PRV1 overexpression is associated with Essential Thrombocythemia and Myelofibrosis.
NB1-proteinase 3 (show PRTN3 Proteins) interactions may play a role in aiding neutrophil transmigration.
pivotal role of the NB1-Mac-1 receptor interaction for PR3-ANCA-mediated neutrophil activation
The increased membrane expression of PR3 (show PRTN3 Proteins) found in ANCA-associated systemic vasculitis is not linked directly to circulating PR3 (show PRTN3 Proteins) or PR3 (show PRTN3 Proteins) gene transcription, but is dependent upon CD177 expression and correlated with the transcription of the CD177 gene.
heterophilic PECAM-1 (show PECAM1 Proteins)/CD177 interactions affect the phosphorylation state of PECAM-1 (show PECAM1 Proteins) and endothelial cell junctional integrity in such a way as to facilitate neutrophil transmigration in a previously unrecognized allele-specific manner.
Herein we established a novel genetic mouse model to study the role of CD177 and found that CD177 plays an important role in neutrophils.
NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971
, CD177 molecule
, CD177 antigen-like
, NB1 glycoprotein
, cell surface receptor
, human neutrophil alloantigen 2a
, polycythemia rubra vera 1
, polycythemia rubra vera protein 1