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CD248 Molecule, Endosialin Proteins (CD248)

May play a role in angiogenesis or vascular function.. Additionally we are shipping CD248 Antibodies (81) and CD248 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CD248 CD248 293669  
CD248 70445 Q91V98
CD248 57124 Q9HCU0
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Top CD248 Proteins at

Showing 3 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

CD248 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
Human ,
, ,

More Proteins for CD248 Molecule, Endosialin (CD248) Interaction Partners

Mouse (Murine) CD248 Molecule, Endosialin (CD248) interaction partners

  1. suggest that CD248 stromal cells have a pathogenic role in renal fibrosis

  2. We conclude that CD248 is required for PDGFRbeta-dependant capillary sprouting but not splitting angiogenesis, and identify a new role for CD248 expressed on pericytes in the early stages of physiological angiogenesis during muscle remodelling.

  3. Tem1-TT vaccination elicited CD8+ and/or CD4+ T cell responses against immunodominant TEM1 protein sequences. Prophylactic immunization of animals with Tem1-TT prevented or delayed tumor formation in several tumor models.

  4. Expression of CD248 was seen in osteoblasts, but not osteoclasts. CD248(-/-) mouse tibiae had higher bone mass and superior mechanical properties compared to WT mice. Primary osteoblasts from CD248(-/-) mice induced increased bone mineralization

  5. The multiple pathways regulated by the cytoplasmic domain of CD248 highlight its potential as a therapeutic target to treat cancer.

  6. our observations suggest that Tem1 is expressed throughout embryonic and adult development in several types of mesenchymal cells closely related to blood vessels.

  7. Tem1 have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process

  8. In the embryo when analysed by confocal microscopy endosialin on vessels does not colocalise with endothelial cells expressing CD31 (show PECAM1 Proteins), rather, endosialin is restricted to closely associated perivascular cells that also express the pericyte marker NG2 (show Vcan Proteins).

  9. CD248 expression helps define a subset of lymphoid tissue stromal cells which play a role in remodelling during tissue development, infection and repair

Human CD248 Molecule, Endosialin (CD248) interaction partners

  1. CD248 overexpression is possibly involved in the pathogenesis of IPF and it has potential as a disease severity marker.

  2. TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer

  3. MORAb-004 reduced CD248 on pericytes, impaired tumor microvasculature maturation and ultimately suppressed tumor development.

  4. The authors show that endosialin, a C-type lectin (show MBL2 Proteins), expressed in the liver exclusively by HSC (show FUT1 Proteins) and portal fibroblasts, is upregulated in liver fibrosis in mouse and man.

  5. The genes CD248, Ephb1 (show EPHB1 Proteins) and P2RY2 (show P2RY2 Proteins) were detected as the top overexpressed in GC biopsies.

  6. new monoclonal antibodies described in this paper are domain-specific and represent important reagents for the study of functional contributions of extracellular endosialin domains

  7. [review] CD248 is a C-type lectin (show MBL2 Proteins)-like domain-containing cell surface glycoprotein (show GJA8 Proteins) that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions.

  8. CD248 defines a subset of stromal cells, including but not limited to some myofibroblasts, linked to albuminuria and tubulointerstitial damage during tissue remodeling in CKD.

  9. endosialin can be detected in advanced sarcoma

  10. Endosialin expression may be involved in the progression of rectal cancers.

CD248 Protein Profile

Protein Summary

May play a role in angiogenesis or vascular function.

Gene names and symbols associated with CD248

  • CD248 molecule, endosialin (Cd248)
  • CD248 antigen, endosialin (Cd248)
  • CD248 molecule, endosialin (CD248)
  • 2610111G01Rik protein
  • AI842296 protein
  • CD164L1 protein
  • TEM1 protein

Protein level used designations for CD248

CD164 sialomucin-like 1 , CD248 antigen, endosialin , endosialin , tumor endothelial marker 1 , 2610111G01Rik

293669 Rattus norvegicus
70445 Mus musculus
57124 Homo sapiens
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