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CD47 encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Additionally we are shipping CD47 Antibodies (278) and CD47 Proteins (42) and many more products for this protein.
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CD47 deficient mice with vaccination showed greater protective efficacy against lethal challenge.
These results indicate an important role for CD47-SIRPalpha interactions in innate control of malaria and suggest novel targets for intervention.
atherogenesis is associated with upregulation of CD47, a key anti-phagocytic molecule that is known to render malignant cells resistant to programmed cell removal, or 'efferocytosis'
Erythrocyte CD47 has a key role in hematoma clearance after intracerebral hemorrhage.
These data indicate that CD47 plays protective roles against disseminated candidiasis and alters pro-inflammatory and immunosuppressive pathways known to regulate innate and T cell immunity.
CD47 deficiency ameliorates lupus nephritis in Fas(lpr (show FAS ELISA Kits)) mice via suppression of IgG autoantibody production.
the cell adhesion molecule (show MCAM ELISA Kits) CD47 participates in multiple phases of granule cell development, including proliferation, migration, and neurite differentiation
CD47 mediates signaling from the extracellular matrix that coordinately regulates basal metabolism and cytoprotective responses to radiation injury
Taken together, these data revealed a novel role for CD47 in the development of obesity and its related metabolic complications.
NF KB mediated CD47 up regulation promotes sorafenib resistance treating hepatocellular carcinoma.
Prolongation of transient porcine chimerism via transgenic expression of human CD47 in a primate model is associated with an immune modulating effect, leading to markedly prolonged survival of donor swine skin xenografts.
CD47 is a promising cancer biomarker, and targeting CD47 presents an effective and potential therapeutic strategy through synthesized mechanisms
CD47 seems to mediate fusion mostly through broad contact surfaces between the partners' cell membrane while syncytin-1 mediate fusion through phagocytic-cup like structure.
The results suggested a critical role of CD47 in laryngeal squamous cell carcinoma development.
Data show that anti-human CD47 antibody B6H12 decreased expression of epidermal growth factor receptor (EGFR (show EGFR ELISA Kits)) and the stem cell transcription factors.
suggest that microglial activation may be partially caused by CD47/signal regulatory protein-alpha (show SIRPA ELISA Kits)- and CD200 (show CD200 ELISA Kits)/CD200R (show CD200R1 ELISA Kits)-mediated reductions in the immune inhibitory pathways
Our results highlight an underappreciated contribution of the adaptive immune system to anti-CD47 adjuvant therapy and suggest that targeting both innate and adaptive immune checkpoints can potentiate the vaccinal effect of antitumor antibody therapy.
Data suggest a reduction in the CD47 antigen/signal-regulatory protein alpha (show SIRPA ELISA Kits) (SIRPalpha) pathway by programmed cell death protein 1 (PD-1 (show PDCD1 ELISA Kits)) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).
CD47 is a critical regulator in the metastasis of osteosarcoma and results suggest that targeted inhibition of this antigen by anti-CD47 may be a novel immunotherapeutic approach in the management of this tumor.
Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 ELISA Kits)- and CD47-dependent manner
Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection.
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.
, integrin-associated protein
, leukocyte surface antigen CD47
, CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
, CD47 glycoprotein
, antigen identified by monoclonal antibody 1D8
, antigenic surface determinant protein OA3
, integrin associated protein
, integrin-associated signal transducer
, CD47 antigen