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May act as a receptor in regulating T-cell proliferation.. Additionally we are shipping CD5 Antibodies (1357) and CD5 Kits (17) and many more products for this protein.
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FasL (show FASL Proteins) expression in splenic CD5(+)CD1d (show CD1D Proteins)(hi) B cells was decreased compared to the control group after TLR4 (show TLR4 Proteins) ligation.
CD5-CK2 signaling axis regulates positive selection by modulating activation of ERK and promoting survival independent of proximal TCR signals
the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency.
In mice lacking functional KDELR1, surviving naive T cells expressed significantly higher levels of CD5, a surrogate marker of TCR self-reactivity.
In mouse tumor models, CD5(+) but not CD5(-) B cells promoted tumor growth. The results demonstrate a critical role of CD5(+) B cells in promoting cancer.
CD5 and CD72 (show CD72 Proteins) play a critical role in maintaining regulatory T and B cell homeostasis
CD5 promoted Treg cell induction in response to self and tolerizing antigens by blocking mTOR (show FRAP1 Proteins) activation.
Data indicate that CD5-casein kinase 2 (CK2 (show CSNK2A1 Proteins)) signaling is necessary for efficient nuclear localization of orphan nuclear receptor (show NR1D1 Proteins) ROR (show RORB Proteins)-gammaT (RORgammat).
These results support the notion that the distal cytoplasmic domain of CD5, including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via c-Cbl (show CBL Proteins).
Although the percentage of CD1d (show CD1D Proteins)(hi)CD5+ subset in splenic B cells does not change significantly, percent IL-10 (show IL10 Proteins)-expressing cells among total splenic B cells or the CD1dhiCD5+ population significantly increases 3-7 days after rCRT/39-272 administration
CD5 transcription is increased, leading to the production of three mRNA isoforms by APA (show ENPEP Proteins), all contributing for protein production, at different levels. PTBP1 (show PTBP1 Proteins) binds in the vicinity of pA1 (show PAGR1 Proteins), leading to an increase in mRNA levels and miR (show MLXIP Proteins)-204 targets the longer CD5 mRNA.
High CD5 expression is associated with lymphoma in Waldeyer ring.
Thus, trans-signaling of IL-6 can only occur via sIL-6R, but not sCD5.
The major proportion of CD5(low) B cells in patients are leukemic, thus identifying CD5(low) B cells as an important component of CLL, with implications for CLL pathogenesis, clinical monitoring, and the development of anti-CD5-directed therapies.
the CD5 Pro224-Ala471 haplotype in homozygosis improved melanoma survival in the entire set of patients (HR = 0.27, 95% CI 0.11-0.67, Adj. p = 0.005). These findings highlight the relevance of genetic variability in immune-related genes for clinical outcome in melanoma.
R-EPOCH therapy does not seem to impact the known poorer prognosis of patients with de novo CD5+ diffuse large B-cell lymphoma , and CD5 expression was still an independent prognostic factor in R-EPOCH-treated patients with diffuse large B-cell lymphoma.
CD5+B lymphocytes were increased and activated in autoimmune hemolytic anemia patients.
This study confirms the poor prognosis of de novo CD5+ DLBCL in a large multi-center cohort despite initial rituximab-containing chemotherapy and suggests that stem cell transplantation fails to salvage the majority of these patients.
5.2 % were positive for CD5 and 5.7 % positive for epstein-Barr virus encoded RNA
CD5 polymorphisms are associated with systemic lupus erythematosus.
Findings suggest that development, selection and function of different B- and T-cell subsets may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like (show CD5L Proteins) molecules expressed on T cells compared to B (show TDO2 Proteins) cells.
May act as a receptor in regulating T-cell proliferation.
, t-cell surface glycoprotein CD5-like
, T-cell surface glycoprotein CD5
, lymphocyte antigen 1
, CD5 antigen (p56-62)
, lymphocyte antigen T1/Leu-1
, CD5 antigen
, Lymphocyte antigen CD5
, CD74 antigen, invariant polypeptide of major
, lymphocyte receptor CD5