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Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Antibodies (77) and CRTC1 Proteins (6) and many more products for this protein.
revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma
CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals.
DNA methylation (show HELLS ELISA Kits) levels within two distinct promoter regions of the CREB regulated transcription coactivator 1 gene were decreased in human hippocampus affected by Alzheimer disease.
Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC (show CCL28 ELISA Kits) diagnosis but is not associated with differences in survival outcomes.
A specific CRTC1-MAMl2-induced transcriptional program was identified in mucoepidermoid carcinoma cells.
Translocation t(11;19)(q14-21;p12 (show POLE4 ELISA Kits)-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13.
This study showed that CREB (show CREB1 ELISA Kits)-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication.
CRTC1 activation is a key event that drives the LKB1 (show STK11 ELISA Kits)-null mRNA signature in lung cancer. We also identified a positive feedback LKB1 (show STK11 ELISA Kits)/CRTC1 signaling loop for COX-2 (show COX2 ELISA Kits)/PGE2 regulation.
describe fundamental metabolic requirements of senescent primary human CD8 (show CD8A ELISA Kits)+ T cells and demonstrate that p38 MAPK (show MAPK14 ELISA Kits) blockade reverses senescence via an mTOR (show FRAP1 ELISA Kits)-independent pathway
Malignant mucoepidermoid salivary gland tumors can arise from a recurrent t (11, 19)(q21;p13.1) translocation that generates an unusual chimeric CRTC1/MAML2 oncoprotein.
IL-4 (show IL4 ELISA Kits) signaling co-opts the Akt (show AKT1 ELISA Kits)-mTORC1 pathway to regulate Acly (show ACLY ELISA Kits), a key enzyme in acetyl-CoA (show LPCAT1 ELISA Kits) synthesis, leading to increased histone acetylation and macrophage gene induction.
Upregulation of CRTC1 enhancing CREB (show CREB1 ELISA Kits)-dependent gene transcription in spinal cord may play an important role in bone cancer pain.
This study demonstrates that TSC1 (show TSC1 ELISA Kits)- mechanistic target of rapamycin (show FRAP1 ELISA Kits) complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]
These data identify Notch (show NOTCH1 ELISA Kits) as a therapeutically actionable branch point of metabolic signaling at which Akt (show AKT1 ELISA Kits) activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]
aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 (show MTM1 ELISA Kits) [mTORC1]
CRTC1 has a wide impact on CREB (show CREB1 ELISA Kits)-dpendent memory processes and fine-tunes CREB (show CREB1 ELISA Kits) output in a region-specific manner.
Translational activation of CREB (show CREB1 ELISA Kits) is caused by elevated phospho-elF2alpha (show EIF2S1 ELISA Kits).
PDK4 (show PDK4 ELISA Kits) promotes tumorigenesis through activation of the CREB (show CREB1 ELISA Kits)-RHEB (show RHEB ELISA Kits)-mTORC1 signaling cascade.
Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer Disease.
Fisetin inhibits Akt (show AKT1 ELISA Kits)-mTORC1 signaling in 3T3-L1 preadipocytes and white adipose tissue in HFD-fed mice.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.
CREB-regulated transcription coactivator 1
, mucoepidermoid carcinoma translocated 1
, CREB regulated transcription coactivator 1
, CREB-regulated transcription coactivator 1-like
, mucoepidermoid carcinoma translocated protein 1
, transducer of regulated cAMP response element-binding protein (CREB) 1
, mucoepidermoid carcinoma translocated protein 1 homolog
, transducer of CREB protein 1
, transducer of regulated cAMP response element-binding protein 1