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CREB Regulated Transcription Coactivator 1 (CRTC1) ELISA Kits

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Antibodies (76) and CRTC1 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human CRTC1 CRTC1 23373 Q6UUV9
Anti-Mouse CRTC1 CRTC1 382056 Q68ED7
Anti-Rat CRTC1 CRTC1 684527 Q157S1
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More ELISA Kits for CRTC1 Interaction Partners

Human CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. DNA methylation (show HELLS ELISA Kits) levels within two distinct promoter regions of the CREB regulated transcription coactivator 1 gene were decreased in human hippocampus affected by Alzheimer disease.

  2. Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC (show CCL28 ELISA Kits) diagnosis but is not associated with differences in survival outcomes.

  3. A specific CRTC1-MAMl2-induced transcriptional program was identified in mucoepidermoid carcinoma cells.

  4. Translocation t(11;19)(q14-21;p12 (show POLE4 ELISA Kits)-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13.

  5. This study showed that CREB (show CREB1 ELISA Kits)-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication.

  6. CRTC1 activation is a key event that drives the LKB1 (show STK11 ELISA Kits)-null mRNA signature in lung cancer. We also identified a positive feedback LKB1 (show STK11 ELISA Kits)/CRTC1 signaling loop for COX-2 (show COX2 ELISA Kits)/PGE2 regulation.

  7. describe fundamental metabolic requirements of senescent primary human CD8 (show CD8A ELISA Kits)+ T cells and demonstrate that p38 MAPK (show MAPK14 ELISA Kits) blockade reverses senescence via an mTOR (show FRAP1 ELISA Kits)-independent pathway

  8. Malignant mucoepidermoid salivary gland tumors can arise from a recurrent t (11, 19)(q21;p13.1) translocation that generates an unusual chimeric CRTC1/MAML2 oncoprotein.

  9. aberrantly activated AREG (show AREG ELISA Kits)-EGFR (show EGFR ELISA Kits) signaling is required for CRTC1-MAML2-positive MEC (show CCL28 ELISA Kits) cell growth and survival, suggesting that EGFR (show EGFR ELISA Kits)-targeted therapies will benefit patients with advanced, unresectable CRTC1-MAML2-positive MEC (show CCL28 ELISA Kits).

  10. Lacrimal and salivary gland PAs and Ca-ex-PAs have similar genomic profiles and frequently overexpress the PLAG1 oncoprotein. Copy number gains involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) may be of importance for disease progression.

Mouse (Murine) CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. IL-4 (show IL4 ELISA Kits) signaling co-opts the Akt (show AKT1 ELISA Kits)-mTORC1 pathway to regulate Acly (show ACLY ELISA Kits), a key enzyme in acetyl-CoA (show LPCAT1 ELISA Kits) synthesis, leading to increased histone acetylation and macrophage gene induction.

  2. Upregulation of CRTC1 enhancing CREB (show CREB1 ELISA Kits)-dependent gene transcription in spinal cord may play an important role in bone cancer pain.

  3. This study demonstrates that TSC1 (show TSC1 ELISA Kits)- mechanistic target of rapamycin (show FRAP1 ELISA Kits) complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]

  4. These data identify Notch (show NOTCH1 ELISA Kits) as a therapeutically actionable branch point of metabolic signaling at which Akt (show AKT1 ELISA Kits) activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]

  5. aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 (show MTM1 ELISA Kits) [mTORC1]

  6. CRTC1 has a wide impact on CREB (show CREB1 ELISA Kits)-dpendent memory processes and fine-tunes CREB (show CREB1 ELISA Kits) output in a region-specific manner.

  7. Translational activation of CREB (show CREB1 ELISA Kits) is caused by elevated phospho-elF2alpha (show EIF2S1 ELISA Kits).

  8. PDK4 (show PDK4 ELISA Kits) promotes tumorigenesis through activation of the CREB (show CREB1 ELISA Kits)-RHEB (show RHEB ELISA Kits)-mTORC1 signaling cascade.

  9. Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer Disease.

  10. Fisetin inhibits Akt (show AKT1 ELISA Kits)-mTORC1 signaling in 3T3-L1 preadipocytes and white adipose tissue in HFD-fed mice.

CRTC1 Antigen Profile

Antigen Summary

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.

Gene names and symbols associated with CRTC1

  • CREB regulated transcription coactivator 1 (CRTC1) antibody
  • CREB regulated transcription coactivator 1 (crtc1) antibody
  • CREB regulated transcription coactivator 1 (Crtc1) antibody
  • AI413414 antibody
  • CRTC1 antibody
  • Mect1 antibody
  • mKIAA0616 antibody
  • R74955 antibody
  • TORC-1 antibody
  • TORC1 antibody
  • WAMTP1 antibody

Protein level used designations for CRTC1

CREB-regulated transcription coactivator 1 , mucoepidermoid carcinoma translocated 1 , CREB regulated transcription coactivator 1 , CREB-regulated transcription coactivator 1-like , mucoepidermoid carcinoma translocated protein 1 , transducer of regulated cAMP response element-binding protein (CREB) 1 , TORC-1 , mucoepidermoid carcinoma translocated protein 1 homolog , transducer of CREB protein 1 , transducer of regulated cAMP response element-binding protein 1

100523662 Sus scrofa
510465 Bos taurus
720274 Macaca mulatta
735806 Pan troglodytes
771015 Gallus gallus
100036611 Xenopus (Silurana) tropicalis
100385682 Callithrix jacchus
100479645 Ailuropoda melanoleuca
100548464 Meleagris gallopavo
23373 Homo sapiens
382056 Mus musculus
684527 Rattus norvegicus
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