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Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (By similarity).. Additionally we are shipping Calpain 2 Antibodies (59) and Calpain 2 Proteins (5) and many more products for this protein.
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Results indicate that calpain-1 (show CAPN1 ELISA Kits) and calpain-2 are differentially activated in hippocampus following seizure activity, with calpain-1 (show CAPN1 ELISA Kits) activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 is widely activated in pyramidal neurons of CA1 (show CA1 ELISA Kits) and CA3 (show CA3 ELISA Kits), and triggers neurodegenerative cascades.
these findings identify ASAP2 (show ASAP2 ELISA Kits) as a new target of Selk (show HSP ELISA Kits)-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis.
ENaC (show SCNN1A ELISA Kits) activity is regulated by calpain-2 proteolysis of MARCKS (show MARCKS ELISA Kits).
calpains and calpastatin (show CAST ELISA Kits) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN ELISA Kits)-5HTT (show SLC6A4 ELISA Kits)(+) strain) PH, were investigated.
Leukocyte calpain-1 (show CAPN1 ELISA Kits)/calpain-2 deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.
These results suggest that TRPV1 (show TRPV1 ELISA Kits)/Ca(2 (show CA2 ELISA Kits)+)/calpain 2-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.
Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension.
LOX-1 (show OLR1 ELISA Kits) is, at least in part, responsible for the inhibitory effect of ox-LDL on macrophage migration and this process involves calpain-1 (show CAPN1 ELISA Kits) and -2.
Dicer is predominantly a Capn2 substrate. Dicer levels were altered in platelets from diabetic mice due to the cleavage of the enzyme by calpain, resulting in loss of function.
Data suggest that vitamin D3 up-regulates skeletal muscle fat deposition, up-regulates muscle m-calpain/Capn2 and u-calpain/Capn1 expression, and down-regulates muscle calpastatin expression.
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (By similarity).
80 kDa M-calpain subunit
, CANP 2
, calcium-activated neutral proteinase 2
, calpain M-type
, calpain-2 catalytic subunit
, calpain-2 large subunit
, cysteine proteinase
, m-calpain 80 kDa large subunit
, m-calpain large subunit
, calpain 2