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The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. Additionally we are shipping CNR2 Kits (13) and CNR2 Proteins (6) and many more products for this protein.
Showing 10 out of 134 products:
Human Monoclonal CNR2 Primary Antibody for IF, ELISA - ABIN514506
Brocato, Zoerner, Janjetovic, Skobowiat, Gupta, Moore, Slominski, Zhang, Schenone, Phinehas, Ferry, Dick, Hubbard, Mari, Schlabritz-Loutsevitch: Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. in Placenta 2013
Horse (Equine) Polyclonal CNR2 Primary Antibody for WB - ABIN2789519
Wilhelmsen, Khakpour, Tran, Sheehan, Schumacher, Xu, Hellman: The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells. in The Journal of biological chemistry 2014
Human Polyclonal CNR2 Primary Antibody for FACS, ICC - ABIN152759
Patsenker, Stoll, Millonig, Agaimy, Wissniowski, Schneider, Mueller, Brenneisen, Seitz, Ocker, Stickel: Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. in Molecular medicine (Cambridge, Mass.) 2012
Human Polyclonal CNR2 Primary Antibody for ELISA, WB - ABIN250889
Van Sickle, Duncan, Kingsley, Mouihate, Urbani, Mackie, Stella, Makriyannis, Piomelli, Davison, Marnett, Di Marzo, Pittman, Patel, Sharkey: Identification and functional characterization of brainstem cannabinoid CB2 receptors. in Science (New York, N.Y.) 2005
Histological analyses revealed numerous endocrinal cell clusters or islets which were distributed among exocrine adenomeri in connectival tissue. Immunohistochemistry showed that endocrine-islets contained some CB2-positive cells with a very peculiar localization that is a few primarily localized at the edges of islets and some of them also scattered in the center of the cluster.
genetic or chemical inhibition of cannabinoid receptor (Cnr (show PCDHA1 Antibodies)) activity disrupts liver development and metabolic function in zebrafish.
Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin (show SELP Antibodies) Activity.
Activation of the Cnr2 receptor inhibits leukocyte migration in response to acute injury.
hepatic expression of CB1 (show CNR1 Antibodies) and CB2 plays an important role during the progression of fibrosis induced by chronic hepatitis B
analysis of the interplay between the CB2-RR variant and liver necroinflammation in chronic hepatitis patients with HIV/HCV coinfection
Patients with schizophrenia showed increased CB2R expression in cells of the innate immune system and simpler correlation network between cytokines and CBRs expression when compared with controls.
Data suggest that signaling via endocannabinoids and CNR1/CNR2 plays central role in food intake; the endocannabinoid system regulates bidirectional communication (in the context of energy intake and storage) between the brain and peripheral tissues (adipose tissue, liver, gastrointestinal tract, endocrine pancreas, and skeletal muscle). [REVIEW]
Selective estrogen receptor (ER (show ESR1 Antibodies)) modulator (SERM) isomers exhibit distinct affinity and selectivity for cannabinoid subtype 1 and 2 receptors (CB1R (show CNR1 Antibodies) and CB2Rs).
We investigated the relationship between variation in the CNR1 (show CNR1 Antibodies), CNR2, and FAAH (show FAAH Antibodies) genes and change in primary anxiety disorder severity. Five SNPs were nominally associated with a poorer treatment response (rs806365 [CNR1 (show CNR1 Antibodies)]; rs2501431 [CNR2]; rs2070956 [CNR2]; rs7769940 [CNR1 (show CNR1 Antibodies)]; rs2209172 [FAAH (show FAAH Antibodies)]) and one with a more favorable response (rs6928813 [CNR1 (show CNR1 Antibodies)]).
Cannabinoid Receptor 2 mutation is associated with obesity.
The type 2 cannabinoid (Cnr2) receptor is implicated in cancer, bone metabolism and pain perception. Emerging data have uncovered the role of Cnr2 in the regulation of tumour-bone cell interactions and suggest that agents that target Cnr2 in the skeleton have potential efficacy in the reduction of skeletal complications associated with cancer. [review]
The prevalence of chronic HCV infected patients with the CB2-63 RR variant was significantly higher in the immune-mediated disorder (IMD (show ADM2 Antibodies)) than in the non-IMD (show ADM2 Antibodies) group. The data suggest a significant, previously unknown, independent association between the CB2-63 RR variant and IMDs (show ADM2 Antibodies) in anti-HCV-positive patients.
Data indicate that mobile tongue squamous cell carcinoma (SCC (show CYP11A1 Antibodies)) patients presenting enhanced cannabinoid receptors CB1R (show CNR1 Antibodies), CB2R, or concomitant CB1R (show CNR1 Antibodies)/CB2R expression showed significantly longer overall and disease-free survival times compared to those with low expression.
activation of CB2R ameliorates DSS (show PMP22 Antibodies)-induced colitis through enhancing autophagy that may inhibit NLRP3 (show NLRP3 Antibodies) inflammasome activation in macrophages.
Data show that (-)-beta-caryophyllene (BCP (show OPN1SW Antibodies)) diminished axonal demyelination and modulated Th1 (show HAND1 Antibodies)/Treg immune balance through the activation of cannabinoid receptor type 2 (CB2 receptor).
Study demonstrated that the activation of CB2R attenuates the ocular pathology associated with the development and progression of experimental proliferative vitreoretinopathy; intervention at early stage proliferative vitreoretinopathy with CB2R agonists reduces ocular inflammation and disease severity.
the M2 macrophage chemokine CCL17 was identified as an essential factor for enhanced survival in the absence of CB2, because CCL17 x Cnr2 double-deficient mice were fully susceptible to experimental cerebral malaria.
Cannabigerol is able to counteract oxidative stress by activation of CB2 receptors. CB2 antagonist pre-treatment indeed blocked the protective effects of Cannabigerol in H2O2 stimulated macrophages, while CB1R (show CNR1 Antibodies) was not involved.
Findings demonstrate that miR (show MLXIP Antibodies)-139 exerts a pathogenic effect in Alzheimer's disease by modulating CB2-meditated neuroinflammatory processes.
Activation of CB2 ameliorates myocardial fibrosis via Nrf2 (show NFE2L2 Antibodies)-mediated inhibition of TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) pathway in mice with myocardial infarction.
This study provides insights into the role of CB2 cannabinoid receptors in regulating cognitive functions such as long-term memory.
Behavioral assays revealed that hippocampus-dependent, long-term contextual fear memory was impaired whereas hippocampus-independent, cued fear memory was normal in CB2 receptor knockout mice. These mice also displayed enhanced spatial working memory when tested in a Y-maze.
Data indicate that, in the mouse hippocampus, CB2R mRNAs are primarily expressed in a subset of excitatory and inhibitory neurons; amount of CB2R mRNAs in the mouse hippocampus is stable during postnatal development, from age 1 week to adulthood
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
cannabinoid receptor 2 (macrophage)
, cannabinoid receptor 2
, cannabinoid receptor 2 type A
, cannabinoid receptor-like cb2-zf
, testis-dominant CNR2 isoform CB2
, CB2 receptor
, peripheral cannabinoid receptor
, cannabinoid receptor 2 (spleen)