CNR2 antibody (C-Term)

Catalog No. ABIN2789519

Cited in 1 publication. The Rabbit Polyclonal anti-CNR2 antibody (ABIN2789519) specifically detects CNR2 in WB. The antibody is reactive with Human, Rat, Mouse and Horse samples.

Quick Overview for CNR2 antibody (C-Term) (ABIN2789519)

Target: CNR2 (Cannabinoid Receptor 2 (CNR2))

Reactivity: Human, Rat, Mouse, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CNR2 Antibody

Binding Specificity: C-Term

Purpose: CNR2 Antibody - C-terminal region

Sequence: MVNPVIYALR SGEIRSSAHH CLAHWKKCVR GLGSEAKEEA PRSSVTETEA

Predicted Reactivity: Horse: 83%, Human: 100%, Mouse: 79%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against CNR2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63486-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-CNR2 antibody (ABIN2789519)

Wilhelmsen, Khakpour, Tran, Sheehan, Schumacher, Xu, Hellman: "The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells." in: The Journal of biological chemistry, Vol. 289, Issue 19, pp. 13079-100, (2014) (PubMed).

Target Details for CNR2

Target: CNR2 (Cannabinoid Receptor 2 (CNR2))

Alternative Name: CNR2

Background:

Background Information: The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.

Gene Name: Cannabinoid receptor 2 (macrophage)

Alternative Symbols: CB2, CX5, CB-2

Protein Name: Cannabinoid receptor 2

Molecular Weight: 40kDa

Gene ID: 1269

NCBI Accession: NP_001832

UniProt: P34972