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The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. Additionally we are shipping CNR2 Antibodies (127) and CNR2 Kits (13) and many more products for this protein.
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Histological analyses revealed numerous endocrinal cell clusters or islets which were distributed among exocrine adenomeri in connectival tissue. Immunohistochemistry showed that endocrine-islets contained some CB2-positive cells with a very peculiar localization that is a few primarily localized at the edges of islets and some of them also scattered in the center of the cluster.
genetic or chemical inhibition of cannabinoid receptor (Cnr (show PCDHA1 Proteins)) activity disrupts liver development and metabolic function in zebrafish.
Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin (show SELP Proteins) Activity.
Activation of the Cnr2 receptor inhibits leukocyte migration in response to acute injury.
Cannabinoid Receptor 2 mutation is associated with obesity.
The type 2 cannabinoid (Cnr2) receptor is implicated in cancer, bone metabolism and pain perception. Emerging data have uncovered the role of Cnr2 in the regulation of tumour-bone cell interactions and suggest that agents that target Cnr2 in the skeleton have potential efficacy in the reduction of skeletal complications associated with cancer. [review]
The prevalence of chronic HCV infected patients with the CB2-63 RR variant was significantly higher in the immune-mediated disorder (IMD (show ADM2 Proteins)) than in the non-IMD (show ADM2 Proteins) group. The data suggest a significant, previously unknown, independent association between the CB2-63 RR variant and IMDs (show ADM2 Proteins) in anti-HCV-positive patients.
Data indicate that mobile tongue squamous cell carcinoma (SCC (show CYP11A1 Proteins)) patients presenting enhanced cannabinoid receptors CB1R (show CNR1 Proteins), CB2R, or concomitant CB1R (show CNR1 Proteins)/CB2R expression showed significantly longer overall and disease-free survival times compared to those with low expression.
This is the first demonstration that the fibroblasts of the muscular fasciae express CB1 (show CNR1 Proteins) and CB2.
Induction of apoptosis was mediated via CB1 (show CNR1 Proteins) as well as CB2, and expression of CB receptors was a prerequisite for therapy response in our models.
CNR2 gene has an important role in the etiology of osteoporosis and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women.
Human lung-resident macrophages express CB1 (show CNR1 Proteins) and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors
A histological activity index (HAI (show SPINT1 Proteins)) > 8 (Ishak scoring) was more frequent in patients with CB2-63 RR than in those with CB2-63 QR or QQ (37% vs. 16.7%, p < 0.05).
Study demonstrates the up-regulation of CB2 receptors in glial elements in postmortem tissues of Parkinson's disease patients and an inflammatory mouse model
Data show that (-)-beta-caryophyllene (BCP (show OPN1SW Proteins)) diminished axonal demyelination and modulated Th1 (show HAND1 Proteins)/Treg immune balance through the activation of cannabinoid receptor type 2 (CB2 receptor).
Study demonstrated that the activation of CB2R attenuates the ocular pathology associated with the development and progression of experimental proliferative vitreoretinopathy; intervention at early stage proliferative vitreoretinopathy with CB2R agonists reduces ocular inflammation and disease severity.
the M2 macrophage chemokine CCL17 was identified as an essential factor for enhanced survival in the absence of CB2, because CCL17 x Cnr2 double-deficient mice were fully susceptible to experimental cerebral malaria.
Cannabigerol is able to counteract oxidative stress by activation of CB2 receptors. CB2 antagonist pre-treatment indeed blocked the protective effects of Cannabigerol in H2O2 stimulated macrophages, while CB1R (show CNR1 Proteins) was not involved.
Findings demonstrate that miR (show MLXIP Proteins)-139 exerts a pathogenic effect in Alzheimer's disease by modulating CB2-meditated neuroinflammatory processes.
Activation of CB2 ameliorates myocardial fibrosis via Nrf2 (show NFE2L2 Proteins)-mediated inhibition of TGF-beta1 (show TGFB1 Proteins)/Smad3 (show SMAD3 Proteins) pathway in mice with myocardial infarction.
This study provides insights into the role of CB2 cannabinoid receptors in regulating cognitive functions such as long-term memory.
Behavioral assays revealed that hippocampus-dependent, long-term contextual fear memory was impaired whereas hippocampus-independent, cued fear memory was normal in CB2 receptor knockout mice. These mice also displayed enhanced spatial working memory when tested in a Y-maze.
Data indicate that, in the mouse hippocampus, CB2R mRNAs are primarily expressed in a subset of excitatory and inhibitory neurons; amount of CB2R mRNAs in the mouse hippocampus is stable during postnatal development, from age 1 week to adulthood
Findings indicate a physiologic role of type 2 cannabinoid receptor (CB2) in regulating the onset of meiosis and in maintaining the homeostasis of spermatogenesis.
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
cannabinoid receptor 2 (macrophage)
, cannabinoid receptor 2
, cannabinoid receptor 2 type A
, cannabinoid receptor-like cb2-zf
, testis-dominant CNR2 isoform CB2
, CB2 receptor
, peripheral cannabinoid receptor
, cannabinoid receptor 2 (spleen)