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anti-Carboxypeptidase B2 (Plasma) (CPB2) Antibodies

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. Additionally we are shipping Carboxypeptidase B2 (Plasma) Kits (53) and Carboxypeptidase B2 (Plasma) Proteins (26) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CPB2 12345 P47757
CPB2 1361  
CPB2 113936 Q9EQV9
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Top anti-Carboxypeptidase B2 (Plasma) Antibodies at antibodies-online.com

Showing 10 out of 172 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CPB2 antibody (Center E134) (ABIN390451) in Jurkat cell line lysates (35 µg/lane). CPB2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells, using CPB2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$347.60
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$356.40
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$356.40
Details
Rat Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$376.20
Details

CPB2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Carboxypeptidase B2 (Plasma) Antibodies

  1. Human Polyclonal CPB2 Primary Antibody for EIA, WB - ABIN452866 : Valnickova, Thogersen, Christensen, Chu, Pizzo, Enghild: Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein. in The Journal of biological chemistry 1996 (PubMed)

  2. Dog (Canine) Polyclonal CPB2 Primary Antibody for WB - ABIN2781326 : Ricart, Ramón, Vayá, España, Santaolaria, Todolí, Castelló, Fontcuberta, Estellés: Fibrinolytic inhibitor levels and polymorphisms in Behçet disease and their association with thrombosis. in British journal of haematology 2008 (PubMed)

More Antibodies against Carboxypeptidase B2 (Plasma) Interaction Partners

Mouse (Murine) Carboxypeptidase B2 (Plasma) (CPB2) interaction partners

  1. Cpb2-deficient mice had decreased pneumococcal meningitis mortality and attenuated cytokine levels and bacterial outgrowth in the syst (show SET Antibodies)emic compartment but not in the brain (show CSF2 Antibodies)compartment, as compared with wild-type mice.

  2. with strain there was significant PKCepsilon (show PRKCE Antibodies) translocation to the Z-disc and co-localization with CapZbeta1 or alpha-actinin (show ACTN1 Antibodies), which was quantified on confocal images.

  3. Carboxypeptidase B2 deficiency reveals that complement C3a (show C3 Antibodies) limits infection and C5a exacerbates infection in a murine polymicrobial sepsis model.

  4. Combination of TAFI (show SET Antibodies)-I and a low dose of rtPA was not as effective as the standard dose of rtPA in treating thromboembolic stroke, while TAFI (show SET Antibodies) inhibition alone was not effective at all.

  5. Capping protein-beta (show CAPZB Antibodies) knockdown decreases filopodial length, alters filopodial shape, and reduces filopodial dynamics.

  6. In an induced osteoarthritis model, CPB2 knockout mice developed dramatically greater cartilage damage than did wild-type mice, had a greater number of osteophytes, and a greater degree of synovitis.

  7. TAFI (show SET Antibodies) deficiency results in accelerated fibrogenesis and increased liver damage in murine models of chronic and acute liver disease, which may be related to increased inflammation.

  8. Actin-capping protein is a novel regulator of microtubule stability that functions by antagonizing mDia1 activity toward actin filaments.

  9. This study suggested that increased expression of TrkB (show NTRK2 Antibodies) and Capzb2 accompanies adequate brain reserve in the initial stages of AD pathology.

  10. The unique NFkappaB site in the mouse CPB2 promoter is functional and mediates the upregulation of mouse CPB2 expression by TNFalpha (show TNF Antibodies).

Human Carboxypeptidase B2 (Plasma) (CPB2) interaction partners

  1. Arg12-Glu28 and Cys383-Val401 in TAFI are involved in thrombomodulin (show THBD Antibodies)-mediated TAFI activation. Gly205-Asp232 is involved in binding to thrombin (show F2 Antibodies).

  2. CPB2 polymorphisms (reference sequences: rs1926447 and rs3742264) were related to systemic complications in bacterial meningitis. TAFI levels correlated positively with CSF (show CSF2 Antibodies) complement. rs1926447 (TT) was associated with higher levels of TAFI in CSF (show CSF2 Antibodies).

  3. Pro-inflammatory cytokines or lipopolysaccharide decreased TAFI protein levels via binding of tristetraprolin (show ZFP36 Antibodies) to the CPB2 3'-UTR (show UTS2R Antibodies), which mediates CPB2 mRNA destabilisation. HuR (show ELAVL1 Antibodies) can bind the CBP2 (show SERPINH1 Antibodies) 3'UTR (show UTS2R Antibodies). This is reduced by pro-inflammatory mediators.

  4. Review/Meta-analysis: failed to confirm the influence of Ala147Thr and Thr325Ile TAFI variants on the susceptibility to CVD. Increased risk of CHD (show CHDH Antibodies) was detected in TAFI Ile325 allele carriers.

  5. TAFI deficiency results in increased brain damage in a model of thrombolysis after ischemic stroke, which was not associated with bleeding but with neuronal degeneration and MP production.

  6. Generated stable deletion mutant of TAFI with full carboxypeptidase activity without activation.

  7. the associations between three TAFI variants -438G/A, 505G/A and 1040C/T and the risk of venous thrombosis; there was a significant association between 505G/A and the risk of disease (Meta-Analysis)

  8. PAI-1 (show SERPINE1 Antibodies) 4G/5G polymorphism does not have any effect on occurrence of intracranial and extracranial hemorrhages in patients with FXIII deficiency, while TAFI Thr325Ile is a strong genetic risk factor.

  9. High plasma TAFI level is associated with the increasing risk of T2DM.

  10. We have demonstrated that TAFI might be a risk factor for the development of SCF (show KITLG Antibodies) independently of conventional cardiovascular risk factors.

Cow (Bovine) Carboxypeptidase B2 (Plasma) (CPB2) interaction partners

  1. analysis of the crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) and description of the structural basis for its intrinsic activity and the short half-life of TAFIa

  2. Purified bovine TAFI activated in the presence of a proteinaceous inhibitor renders a stable enzyme-inhibitor complex.

  3. Findings presented here suggest that the properties of these two orthologous proteins are similar and that conclusions reached using the bovine TAFI may be extrapolated to the human TAFI protein.

Carboxypeptidase B2 (Plasma) (CPB2) Antigen Profile

Protein Summary

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region.

Gene names and symbols associated with CPB2

  • capping protein (actin filament) muscle Z-line, beta (Capzb) antibody
  • carboxypeptidase B2 (plasma) (CPB2) antibody
  • carboxypeptidase B2 (plasma) (Cpb2) antibody
  • 1110032P04Rik antibody
  • 1700120C01Rik antibody
  • 4930405E17Rik antibody
  • AI255929 antibody
  • AI325129 antibody
  • Cappb1 antibody
  • CPB1 antibody
  • CPB2 antibody
  • CPbeat2 antibody
  • CPbeta1 antibody
  • CPbeta2 antibody
  • CPR antibody
  • Cpu antibody
  • pCPB antibody
  • TAFI antibody

Protein level used designations for CPB2

F-actin-capping protein subunit beta , capZ beta , capping protein beta 1 , carboxypeptidase B-like protein , carboxypeptidase B2 , carboxypeptidase B2 (plasma, carboxypeptidase U) , carboxypeptidase R , thrombin-activable fibrinolysis inhibitor , thrombin-activatable fibrinolysis inhibitor , carboxypeptidase U , CPR , CPU , TAFI , plasma carboxypeptidase B

GENE ID SPECIES
12345 Mus musculus
1361 Homo sapiens
56373 Mus musculus
608910 Canis lupus familiaris
113936 Rattus norvegicus
508222 Bos taurus
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