CPB2 antibody (AA 165-387)

Catalog No. ABIN4886546

There is 1 publication for this product available. The Rabbit Polyclonal anti-CPB2 antibody is suitable to detect CPB2 in samples from Mouse. It has been validated for WB.

Quick Overview for CPB2 antibody (AA 165-387) (ABIN4886546)

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CPB2 Antibody

Binding Specificity: AA 165-387

Purpose: Anti-Carboxypeptidase B2/CPB2 Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: coli-derived mouse CPB2 recombinant protein (Position: K165-D387). Mouse CPB2 shares 86.1%,96.9% amino acid (aa) sequence identity with human,rat CPB2,respectively.

Characteristics: Anti-Carboxypeptidase B2/CPB2 Antibody. Tested in WB applications. This antibody reacts with Mouse.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse CPB2 recombinant protein (Position: K165-D387). Mouse CPB2 shares 86.1% and 96.9% amino acid (aa) sequence identity with human and rat CPB2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Mouse

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-CPB2 antibody (ABIN4886546)

Qin, Zeng, Tian, Deng, Ren, Zheng, Li, Li, Liao, Chen: "Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats." in: Clinical and experimental pharmacology & physiology, Vol. 36, Issue 3, pp. 319-24, (2009) (PubMed).

Target Details for CPB2

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Alternative Name: Cpb2

Background:

Background: Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

Gene Full Name: carboxypeptidase B2

Molecular Weight: 48 kDa

Gene ID: 56373

UniProt: Q9JHH6

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis