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anti-Cartilage Oligomeric Matrix Protein (COMP) Antibodies

The protein encoded by COMP is a noncollagenous extracellular matrix (ECM) protein. Additionally we are shipping COMP Kits (57) and COMP Proteins (22) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COMP 25304 P35444
COMP 1311 P49747
COMP 12845 Q9R0G6
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Top anti-COMP Antibodies at

Showing 10 out of 125 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
Human Rat Un-conjugated EIA, IHC (fro), IHC (p), IP, WB   2 mL Log in to see 6 to 8 Days
Rat Chicken Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of COMP Antibody (Center) (ABIN390893) in Jurkat cell line lysates (35 µg/lane). COMP (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with COMP Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated WB Western Blot analysis of COMP expression in transfected 293T cell line by COMP MaxPab polyclonal antibody.Lane 1: COMP transfected lysate(79.64 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
Human Rabbit Un-conjugated WB   0.1 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated WB Raji cell lysates probed with Rabbit Anti-COMP Polyclonal Antibody, Unconjugated (ABIN2559644) at 1:300 in 4˚C. Followed by conjugation to secondary antibody at 1:5000 for 90min at 37˚C. 100 μL Log in to see 3 to 7 Days
Human Rat Un-conjugated IHC (fro), IHC (p), IP, IHC, ELISA, WB Western Blot: COMP/Thrombospondin-5 Antibody (MA37C94 (HC484D1)) [ABIN2557989] - Purifed COMP from conditioned media. Image from verified customer review. 1 mL Log in to see 5 to 7 Days
Human Rat Un-conjugated IHC (fro), IHC (p), IP, ELISA   2000 μL Log in to see 8 to 10 Days
Rat Mouse Un-conjugated EIA, IP, WB   0.1 mL Log in to see 11 to 16 Days

COMP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus) ,
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Mouse (Murine) ,

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Top referenced anti-COMP Antibodies

  1. Human Monoclonal COMP Primary Antibody for EIA, IHC (fro) - ABIN118963 : Milz, Sicking, Sprecher, Putz, Benjamin: An immunohistochemical study of the triangular fibrocartilage complex of the wrist: regional variations in cartilage phenotype. in Journal of anatomy 2007 (PubMed)
    Show all 4 references for ABIN118963

  2. Rat (Rattus) Monoclonal COMP Primary Antibody for EIA, IP - ABIN187632 : Newton, Weremowicz, Morton, Copeland, Gilbert, Jenkins, Lawler: Characterization of human and mouse cartilage oligomeric matrix protein. in Genomics 1995 (PubMed)
    Show all 2 references for ABIN187632

  3. Human Polyclonal COMP Primary Antibody for WB - ABIN191480 : Spitznagel, Nitsche, Paulsson, Maurer, Zaucke: Characterization of a pseudoachondroplasia-associated mutation (His587-->Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP). in The Biochemical journal 2004 (PubMed)

  4. Human Polyclonal COMP Primary Antibody for EIA, WB - ABIN452859 : Kim, Lee, Kim: Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race. in European journal of applied physiology 2009 (PubMed)

  5. Human Polyclonal COMP Primary Antibody for WB - ABIN947722 : Clement, Aphkhazava, Nieves, Callaway, Olszewski, Rotzschke, Santambrogio: Protein expression profiles of human lymph and plasma mapped by 2D-DIGE and 1D SDS-PAGE coupled with nanoLC-ESI-MS/MS bottom-up proteomics. in Journal of proteomics 2013 (PubMed)

More Antibodies against COMP Interaction Partners

Horse (Equine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. The aims of this study were to investigate the proteomic composition of injured tendons during early and late disease stages to identify disease-specific cleavage patterns of the extracellular matrix protein cartilage oligomeric matrix protein (COMP).

  2. The present results suggest that not only type III collagen (show COL3A1 Antibodies) but also cartilage oligomeric matrix protein is involved in the repair and remodeling processes of the digital flexor tendon.

  3. Within the limitations of the study design, production of COMP during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 (show TGFB1 Antibodies) concentrations.

  4. COMP concentrations in digital flexor tendon sheath synovial fluid were significantly greater than those in normal horses with noninfected tenosynovitis caused by intrathecal tendon/ligament tearing, but not by other lesions.

  5. The present study indicates that dynamic in vivo compression at high load and frequency lowers matrix content of COMP in the articular cartilage of the third carpal bone.

Human Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. In the absence of ultrasonographic knee cartilage deformation, the response of serum lubricin (show PRG4 Antibodies) and COMP following acute vigorous exercise indicates an increase in joint lubrication and cartilage metabolism, respectively, which appears largely independent of exercise modality.

  2. Running appears to decrease knee intra-articular pro-inflammatory cytokine concentration and facilitates the movement of COMP from the joint space to the serum.

  3. Results suggest that serum oligomeric matrix protein and hyaluronic acid (COMP and HA) concentrations can be used to predict early cartilage lesions in the knee.

  4. Serum COMP levels are predictive of subsequent structural changes and incidence of painful knee osteoarthritis.

  5. The expression of COMP in circulation reflects the severity of rheumatoid arthritis.

  6. findings suggest that Cartilage oligomeric matrix protein (COMP) is associated with the stage of liver fibrosis in chronic hepatitis C

  7. The GG genotype of Med23 (show MED23 Antibodies) gene associate with Cognitive Decline and Dementia.

  8. COMP does not directly modify the expression of genes involved in cartilage homeostasis in contrast to several other cartilage matrix proteins.

  9. Overexpression of COMP inhibits BMP-2 (show BMP2 Antibodies)-induced osteogenic differentiation and promotes BMP-2 (show BMP2 Antibodies)-induced chondrogenic differentiation.

  10. Real-time polymerase chain reaction (RT-PCR) assay presented significantly higher (p<0.01) COMP expression of mesenchymal stem cells cultured with HA/COMP multilayered films.

Mouse (Murine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. COMP forms a complex with collagens intracellularly that is a prerequisite for collagen secretion.

  2. COMP-Ang1 (show ANGPT1 Antibodies) can enhance BMP2 (show BMP2 Antibodies)-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.

  3. COMP deficiency shortened tail-bleeding and clotting time and accelerated ferric-chloride-induced thrombosis. COMP specifically inhibited thrombin-induced platelet aggregation, activation, and retraction and the thrombin-mediated cleavage of fibrinogen.

  4. COMP immunoreactivity was observed in about half of the investigated plaques from the ApoE (show APOE Antibodies) null mice, mainly located along the intima-medial border. Plaques in the brachiocephalic artery from ApoE (show APOE Antibodies) mice lacking COMP were increased in size with 54%.

  5. study will facilitate better awareness of the differential diagnoses that might be associated with the PSACH/MED spectrum and subsequent care of PSACH/MED patients

  6. The lack of arthritis, together with high levels of COMP-specific antibodies, in COMP-deficient mice indicates that susceptibility to arthritis is COMP specific and that endogenous expression of COMP in wild-type mice tolerizes B cells in vivo.

  7. results imply that COMP is not a key upstream mediator of the anabolic effects of ML on the skeleton.

  8. Lack of COMP and matrilin 3 (show MATN3 Antibodies) leads to increased deposition of TIMP-3 (show TIMP3 Antibodies), which causes partial inactivation of matrix metalloproteinases in bone, including MMP-13 (show MMP13 Antibodies).

  9. A novel form of chondrocyte stress triggered by the expression of a human-like mutation in COMP is central to the pathogenesis of pseudoachondroplasia.

  10. reducing steady state levels of COMP mRNA alleviates intracellular retention of other extracellular matrix proteins associated with the pseudoachondroplasia cellular pathology

Cow (Bovine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. COMP synthesis is differentially regulated by TGFbeta1 (show TGFB1 Antibodies) in the surface and middle zones of bovine articular cartilage.

  2. role for proteinases other than MMPs in the degradation of COMP in cartilage

  3. COMP mutant expression in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP

  4. COMP mRNA expression level was markedly increased by ball oscillation.

  5. COMP acts as a catalyst in collagen fibrillogenesis.

COMP Antigen Profile

Protein Summary

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Gene names and symbols associated with COMP

  • cartilage oligomeric matrix protein (COMP) antibody
  • cartilage oligomeric matrix protein (sce3551) antibody
  • cartilage oligomeric matrix protein (CJA_1292) antibody
  • cartilage oligomeric matrix protein (Comp) antibody
  • COMP antibody
  • EDM1 antibody
  • EPD1 antibody
  • MED antibody
  • PSACH antibody
  • THBS5 antibody
  • TSP5 antibody

Protein level used designations for COMP

cartilage oligomeric matrix protein , TSP5 , cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , pseudoachondroplasia (epiphyseal dysplasia 1, multiple) , thrombospondin-5 , putative cartilage oligomeric matrix protein

469068 Pan troglodytes
5808591 Sorangium cellulosum So ce56
6415089 Cellvibrio japonicus Ueda107
100033911 Equus caballus
25304 Rattus norvegicus
1311 Homo sapiens
12845 Mus musculus
281088 Bos taurus
100720040 Cavia porcellus
396554 Sus scrofa
476665 Canis lupus familiaris
420120 Gallus gallus
101107864 Ovis aries
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