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anti-Cathepsin L1 (CTSL1) Antibodies

The protein encoded by CTSL1 is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Additionally we are shipping Cathepsin L1 Kits (49) and Cathepsin L1 Proteins (43) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CTSL1 1514 P07711
CTSL1 13039 P06797
CTSL1 25697 P07154
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Top anti-Cathepsin L1 Antibodies at

Showing 10 out of 181 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated ICC, IHC (fro), IF, IHC, MA, ELISA, WB Western Blot: Cathepsin L Antibody (33/2) [ABIN151302] - Whole cell extract of Mv 1 Lu cultured mink lung was separated on SDS-PAGE and blotted with Monoclonal Anti-Cathepsin L. The antibody was developed with Goat Anti-Mouse IgG (Fab), AlkPhos Conjugate and NBT/BCIP substrate. Lane A: Antibody dilution 1:400. Lane B: Negative control (only secondary antibody). 0.1 mL Log in to see 5 to 7 Days
Human Mouse Un-conjugated IF, WB Western blot analysis of Cathepsin L on A431 cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-Cathepsin L antibody. 50 μg Log in to see 5 to 6 Days
Human Rabbit Un-conjugated IF (cc), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat skin labeled with Anti-Cathepsin L/CTSL Polyclonal Antibody (ABIN687532), Unconjugated followed by conjugation to the secondary antibody and DAB staining L1 rat liver, L2 rat brain lysates probed (ABIN687532) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band and observed band size: 37kDa. 100 μL Log in to see 3 to 7 Days
Human Rabbit Un-conjugated IHC, WB Western blot analysis of Cathepsin L with rat kidney tissue lysate. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Colon, antibody was diluted at 1:100. 100 μL Log in to see 14 Days
Mouse Rabbit Un-conjugated IP, ELISA, WB 100 μg Log in to see 16 Days
Human Mouse Un-conjugated ELISA, WB Western Blot: Cathepsin L Antibody (2H7) [NBP1-04284] - The recombinant fusion proteins (Cathepsin B, D, K, L and S), and cell lysates of A549 (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human Cathepsin L (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. 0.1 mL Log in to see 5 to 7 Days
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days

CTSL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Cathepsin L1 Antibodies

  1. Human Monoclonal Cathepsin L1 Primary Antibody for ICC, IHC (fro) - ABIN151302 : Igdoura, Morales, Hermo: Differential expression of cathepsins B and D in testis and epididymis of adult rats. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995 (PubMed)
    Show all 13 references for ABIN151302

  2. Human Monoclonal Cathepsin L1 Primary Antibody for EIA, IHC (p) - ABIN317508 : Klionsky: The molecular machinery of autophagy: unanswered questions. in Journal of cell science 2004 (PubMed)
    Show all 4 references for ABIN317508

  3. Human Monoclonal Cathepsin L1 Primary Antibody for IF, WB - ABIN968359 : Ishidoh, Kominami: Procathepsin L degrades extracellular matrix proteins in the presence of glycosaminoglycans in vitro. in Biochemical and biophysical research communications 1996 (PubMed)
    Show all 3 references for ABIN968359

  4. Human Polyclonal Cathepsin L1 Primary Antibody for IHC, WB - ABIN222981 : Song, Spencer, Bazer: Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau. in Endocrinology 2005 (PubMed)
    Show all 2 references for ABIN222981

  5. Mouse (Murine) Polyclonal Cathepsin L1 Primary Antibody for IP, ELISA - ABIN2000123 : Dixit, Dixit, Sharma: Immunodiagnostic/protective role of cathepsin L cysteine proteinases secreted by Fasciola species. in Veterinary parasitology 2008 (PubMed)

  6. Human Polyclonal Cathepsin L1 Primary Antibody for IF (cc), IF (p) - ABIN687532 : Hernáez, Guerra, Salas, Andrés: African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes. in PLoS pathogens 2016 (PubMed)

More Antibodies against Cathepsin L1 Interaction Partners

Xenopus laevis Cathepsin L1 (CTSL1) interaction partners

  1. These results suggest that an antipain-sensitive protease or cathepsin L (or a related protease) is a candidate for pp25 degradation.

Human Cathepsin L1 (CTSL1) interaction partners

  1. endothelial CTSL up-regulation partially due to Fli1 (show FLI1 Antibodies) deficiency may contribute to the development of vasculopathy, while the decrease in dermal CTSL expression is likely associated with dermal fibrosis in systemic sclerosis

  2. CTSL may contribute to gefitinib resistance in non-small-cell lung cancer

  3. The study results indicate the A-allele of rs3118869 [of the human cathepsin Lgene] is a protective factor in hypertension.

  4. Data suggest that nuclear cathepsin L accelerates cell cycle progression of HCT116 colorectal carcinoma cells.

  5. Mechanistic studies showed that teicoplanin blocks Ebola virus entry by specifically inhibiting the activity of cathepsin L, opening a novel avenue for the development of additional glycopeptides as potential inhibitors of cathepsin L-dependent viruses.

  6. Cathepsin L targeting in cancer treatment

  7. cathepsin L activity was decreased in p53 (show TP53 Antibodies) positive cells after adriamycin treatment, but not in p53 (show TP53 Antibodies) negative cells.

  8. these data indicate that the CTSL inhibitor KGP94 has the potential to alleviate metastatic disease progression and associated skeletal morbidities and hence may have utility in the treatment of advanced prostate cancer patients

  9. p41 (show EPB41 Antibodies) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (show IL12A Antibodies)/p70 (show ANXA6 Antibodies)) during the subsequent maturation of treated dendritic cells.

  10. Our findings highlight the potential role of CTSL in the cross talk between autophagy and apoptosis, which might be considered a therapeutic strategy for treatment of pathologic conditions associated with neurodegeneration.

Mouse (Murine) Cathepsin L1 (CTSL1) interaction partners

  1. findings suggest that single chain-cathepsin L is biologically active in promoting Th17 generation and is counter-regulated by serpinB1 (show SERPINB1 Antibodies) and secondarily by asparagine endopeptidase.

  2. CTSL plays an important role in the MHC class II-mediated peptide presentation in thymic epithelial cells, acting both in the invariant chain degradation and in the generation of MHC class II-bound peptide ligands presented by cortical thymic epithelial cells. Consequently, CTSL plays an important role in the positive selection of CD4 (show CD4 Antibodies)+ T cell in thymus.

  3. genetic blockade of cathepsin L activity is inferred to retard Myc (show MYC Antibodies)-driven tumor growth, encouraging the potential utility of pharmacological inhibitors of cysteine cathepsins in treating late stage tumors.

  4. Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C (show CTSC Antibodies), and TINAGL1 (show TINAGL1 Antibodies) in placenta.

  5. CtsB (show CTSB Antibodies) and CtsL are essential in alpha-syn lysosomal degradation

  6. The phenotypes of cathepsin L deficiency can be fully assigned to lack of canonically targeted cathepsin L, while the biogenesis and functionality of nucleo-cytosolic cathepsin L remain elusive.

  7. in vivo functional evidence for overexpressed CTSL as a promoter of lung metastasis, whereas high CTSL levels are maintained during tumor progression due to stress-resistant mRNA translation.

  8. cathepsin L has a protective role in mouse skin carcinogenesis

  9. Cathepsin L is involved in nociception in mice, whereas peripheral autophagy and cathepsin L contribute, at least in part, to the antinociceptive effect of dimethoxybenzylidene in mice.

  10. a degradative Ctsl-MMP-2 axis, resulting in increased MMP-2 levels upon cathepsin deficiency with subsequent degradation of secreted proteins such as collagen alpha-1 (I).

Pig (Porcine) Cathepsin L1 (CTSL1) interaction partners

  1. Endosomal acidification and cathepsin L (show CTSL Antibodies) activity is required for porcine enteric calicivirus replication.

  2. CTSL1 is expressed by endometrial epithelia, placental areolae, and neonatal intestine, and it may function in the transport of macromolecules across these epithelia.

  3. These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.

Cow (Bovine) Cathepsin L1 (CTSL1) interaction partners

  1. The cathepsin L (show CTSL Antibodies) deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.

  2. Cathepsin L (show CTSL Antibodies) has an previously uncharacterized biological role in the production of [Met]enkephalin, an endogenous peptide neurotransmitter

  3. Secretory vesicle function of cathepsin L (show CTSL Antibodies) for biosynthesis of active enkephalin opioid peptide contrasts with its function in lysosomes for protein degradation.

Cathepsin L1 (CTSL1) Antigen Profile

Protein Summary

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with anti-Cathepsin L1 (CTSL1) Antibodies

  • cathepsin K, like (ctskl) antibody
  • cathepsin L1 (ctsl1) antibody
  • cathepsin L1 (CTSL1) antibody
  • Cathepsin L1 (catl1) antibody
  • cathepsin L1 (Tsp_11596) antibody
  • cathepsin L (CTSL) antibody
  • cathepsin L (Ctsl) antibody
  • cathepsin L family member 3 (CTSL3) antibody
  • cathepsin L1 (Ctsl1) antibody
  • cathepsin L2 (CTSL2) antibody
  • 1190035F06Rik antibody
  • CATHL antibody
  • CatL antibody
  • cpl-1 antibody
  • Ctsl antibody
  • Ctsl1 antibody
  • CTSL2 antibody
  • fs antibody
  • MEP antibody
  • MGC80629 antibody
  • MGC107932 antibody
  • nkt antibody
  • si:dkey-121a11.6 antibody

Protein level used designations for anti-Cathepsin L1 (CTSL1) Antibodies

cathepsin L1 , cathepsin L , Cathepsin L1 , cathepsin L1-like , major excreted protein , Cat L , furless , nackt , p39 cysteine proteinase , CP-2 , MEP , cyclic protein 2 , cathepsin L2 preproprotein

567046 Danio rerio
444163 Xenopus laevis
548464 Xenopus (Silurana) tropicalis
737449 Pan troglodytes
100286607 Salmo salar
100412536 Callithrix jacchus
10912974 Trichinella spiralis
100604414 Nomascus leucogenys
1514 Homo sapiens
13039 Mus musculus
484140 Canis lupus familiaris
25697 Rattus norvegicus
396926 Sus scrofa
515200 Bos taurus
100008830 Oryctolagus cuniculus
101113725 Ovis aries
281108 Bos taurus
427466 Gallus gallus
100684364 Canis lupus familiaris
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