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CRBN encodes a protein related to the Lon protease protein family. Additionally we are shipping Cereblon Antibodies (35) and Cereblon Proteins (8) and many more products for this protein.
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High CRBN expression is associated with multiple myeloma.
CRBN negatively regulates TLR4 (show TLR4 ELISA Kits) signaling via attenuation of TRAF6 (show TRAF6 ELISA Kits) and TAB2 (show TAB2 ELISA Kits) ubiquitination.
Compared with newly diagnosed multiple myeloma, an increased prevalence of mutations in the Ras pathway genes KRAS, NRAS (show NRAS ELISA Kits), and/or BRAF (show BRAF ELISA Kits) (72%), as well as TP53 (show TP53 ELISA Kits) (26%), CRBN (12%), and CRBN pathway genes (10%) was observed.
results suggest that CRBN binds to Ikaros (show IKZF1 ELISA Kits) via its N-terminal region and regulates transcriptional activities of Ikaros (show IKZF1 ELISA Kits) and its downstream target, enkephalin
dual assay demonstrated superior Cereblon IHC measurement in MM samples compared with the single IHC assay using a published commercial rabbit polyclonal Cereblon antibody and could be used to explore the potential utility of Cereblon as a biomarker in the clinic
IRF4 (show IRF4 ELISA Kits) and CRBN polymorphisms affect risk and response to treatment in multiple myeloma
overview of the current understanding of mechanism of action of Immunomodulatory drugs via CRBN and prospects for the development of new drugs that degrade protein of interest.
45.2 of multiple myeloma patients were CRBN(+). Among patients treated with thalidomide-based regimens, CRBN(+) patients showed a better treatment response than did CRBN-negative patients. There was no significant difference in survival outcomes between thalidomide- and bortezomib-based regimens in CRBN(+) patients.
These results support the notion that the cereblon binding partner AGO2 (show EIF2C2 ELISA Kits) plays an important role in regulating MM cell growth and survival and AGO2 (show EIF2C2 ELISA Kits) could be considered as a novel drug target for overcoming IMiD resistance in MM cells.
The anti-PEL effects of IMiDs involved cereblon-dependent suppression of IRF4 (show IRF4 ELISA Kits) and rapid degradation of IKZF1 (show IKZF1 ELISA Kits), but not IKZF3 (show IKZF3 ELISA Kits). Small hairpin RNA-mediated knockdown of MYC (show MYC ELISA Kits) enhanced the cytotoxicity of IMiDs
CRBN is involved in the activation of PERK (show EIF2AK3 ELISA Kits) and the Ire1 (show ERN1 ELISA Kits) pathway of the unfolded protein response.CRBN plays a role in cellular stress signaling, including the unfolded protein response, by controlling the activity of AMPK (show PRKAA1 ELISA Kits).
results of this study suggest a plausible mechanism for CRBN involvement in higher brain function in humans, and they may help explain how a specific mutation in CRBN can affect the cognitive ability of patients
Found significantly smaller infarct sizes and less fibrosis in the hearts of CRBN KO mice than in those of WT mice. Apoptosis was also significantly reduced in the KO mice compared with that in WT mice.
findings suggest that crbn-/- mice exhibit selective HPC-dependent deficits in associative learning.
CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK (show PRKAA2 ELISA Kits) alpha1) and inhibits the activation of AMPK (show PRKAA1 ELISA Kits) activation.
These results imply that Nrf2 (show NFE2L2 ELISA Kits) stimulates CRBN gene transcription under hypoxia-reoxygenation conditions in neuronal cells.
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
, protein cereblon-like
, protein x 0001
, novel lethal
, protein PiL
, Protein cereblon